Recent Advances in the Pathogenesis, Prevention and Management of Type 2 Diabetes and its Complications 46 peripheral arterial disease (PAD), but also affect microvessels leading to "diabetic complications", i.e. diabetes-specific long-term complications of chronic hyperglycemia: retinopathy, nephropathy or neuropathy. Certain vascular diabetic complications such as PAD, TIA/stroke, nephropathy or erectile dysfunction may arise from a combination of macro-and microangiopathies [1-6].