The embryonic cell lineage of the nematode Rhabditophanes sp.

Houthoofd, Wouter; Willems, Maxime; Jacobsen, Kim; Coomans, A.; Borgonie, Gaëtan

doi:10.1387/ijdb.072404wh

Cited by 15 publications

(10 citation statements)

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“…Other species within the Tylenchina a.k.a. Clade IV have also been described, such as Rhabditophanes ( Houthoofd et al 2008 ), Halicephalobus ( Borgonie et al 2000 ), as well as from the more distantly related Spirurina a.k.a. Clade III ( Ascaris ; Boveri 1899 ).…”

Section: Resultsmentioning

confidence: 99%

From “the Worm” to “the Worms” and Back Again: The Evolutionary Developmental Biology of Nematodes

2018

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Section: Resultsmentioning

confidence: 99%

From “the Worm” to “the Worms” and Back Again: The Evolutionary Developmental Biology of Nematodes

2018

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“…But the recently determined nearly complete cell lineages of two other nematodes that develop slowly ( Halicephalobus gingivalis and Rhabditophanes sp.) exhibit similar non-clonality [51], [52], suggesting that selection for rapid development is not the cause of the observed non-clonality in nematodes. Furthermore, selection for fast development cannot explain other robustness-enhancing features of cell lineages (e.g., early appearances of rare cell types).…”

Section: Discussionmentioning

confidence: 91%

Determinative Developmental Cell Lineages Are Robust to Cell Deaths

2014

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All forms of life are confronted with environmental and genetic perturbations, making phenotypic robustness an important characteristic of life. Although development has long been viewed as a key component of phenotypic robustness, the underlying mechanism is unclear. Here we report that the determinative developmental cell lineages of two protostomes and one deuterostome are structured such that the resulting cellular compositions of the organisms are only modestly affected by cell deaths. Several features of the cell lineages, including their shallowness, topology, early ontogenic appearances of rare cells, and non-clonality of most cell types, underlie the robustness. Simple simulations of cell lineage evolution demonstrate the possibility that the observed robustness arose as an adaptation in the face of random cell deaths in development. These results reveal general organizing principles of determinative developmental cell lineages and a conceptually new mechanism of phenotypic robustness, both of which have important implications for development and evolution.

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“…For a better understanding of how evolution proceeded to species with a complex polyclonal lineage as found in C. elegans [14] and all other studied representatives of clades 7 to 12 [29,50,61] our findings in Plectus may be helpful.…”

Section: Discussionmentioning

confidence: 99%

Plectus - a stepping stone in embryonic cell lineage evolution of nematodes

Schulze

Houthoofd

Uenk

et al. 2012

EvoDevo

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BackgroundRecent studies have challenged the widespread view that the pattern of embryogenesis found in Caenorhabditis elegans (clade 9) is characteristic of nematodes in general. To understand this still largely unexplored landscape of developmental events, we set out to examine more distantly related nematodes in detail for temporospatial differences in pattern formation and cell specification. Members of the genus Plectus (clade 6) seem to be suitable candidates to show variety, with certain idiosyncratic features during early development and the convenient availability of cultivatable species.MethodsThe study was conducted using 4-D lineage analysis, 3-D modeling of developing embryos and laser-induced ablation of individual blastomeres.ResultsDetailed cell lineage studies of several Plectus species reveal that pattern formation and cell fate assignment differ markedly from C. elegans. Descendants of the first somatic founder cell S1 (AB) - but not the progeny of other founder cells - demonstrate extremely variable spatial arrangements illustrating that here distinct early cell-cell interactions between invariant partners, as found in C. elegans, cannot take place. Different from C. elegans, in Plectus alternative positional variations among early S1 blastomeres resulting in a ‘situs inversus’ pattern, nevertheless give rise to adults with normal left-right asymmetries. In addition, laser ablations of early blastomeres uncover inductions between variable cell partners.ConclusionsOur results suggest that embryonic cell specification in Plectus is not correlated with cell lineage but with position. With this peculiarity, Plectus appears to occupy an intermediate position between basal nematodes displaying a variable early development and the C. elegans-like invariant pattern. We suggest that indeterminate pattern formation associated with late, position-dependent fate assignment represents a plesiomorphic character among nematodes predominant in certain basal clades but lost in derived clades. Thus, the behavior of S1 cells in Plectus can be considered an evolutionary relict in a transition phase between two different developmental strategies.

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The embryonic cell lineage of the nematode Rhabditophanes sp.

Cited by 15 publications

References 15 publications

From “the Worm” to “the Worms” and Back Again: The Evolutionary Developmental Biology of Nematodes

From “the Worm” to “the Worms” and Back Again: The Evolutionary Developmental Biology of Nematodes

Determinative Developmental Cell Lineages Are Robust to Cell Deaths

Plectus - a stepping stone in embryonic cell lineage evolution of nematodes

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