The Emergence and Zoonotic Transmission of H10Nx Avian Influenza Virus Infections

Everest, Holly; Billington, Elizabeth; Daines, Rebecca; Burman, Alice; Iqbal, Munir

doi:10.1128/mbio.01785-21

Cited by 8 publications

(6 citation statements)

References 108 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…2 Variations in antigenicity and phylogenetics of the haemagglutinin (HA) and neuraminidase (NA) proteins allow them to be divided into subtypes designated H(x)N(y) with 18HA and 11 NA subtypes have been identified. 3 …”

Section: Methodsmentioning

confidence: 99%

“…Virus strains are designated highly pathogenic avian influenza (HPAI) when, or if, the HA cleavage site is polybasic and is recognized by ubiquitous cellular proteases, leading to systemic and often fatal infection in poultry. 3 Low-pathogenic avian influenza (LPAI) causes localized and limited infection and has an HA cleavage site identified only by trypsin-like proteases. 3 Only LPAI subtypes H5 and H7 have displayed this phenotype in natural isolates.…”

Section: Methodsmentioning

confidence: 99%

“… 3 Low-pathogenic avian influenza (LPAI) causes localized and limited infection and has an HA cleavage site identified only by trypsin-like proteases. 3 Only LPAI subtypes H5 and H7 have displayed this phenotype in natural isolates. 3 …”

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

The Biosafety Research Road Map: The Search for Evidence to Support Practices in the Laboratory—Zoonotic Avian Influenza and Mycobacterium tuberculosis

et al. 2023

View full text Add to dashboard Cite

Introduction: The Biosafety Research Road Map reviewed the scientific literature on a viral respiratory pathogen, avian influenza virus, and a bacterial respiratory pathogen, Mycobacterium tuberculosis. This project aims at identifying gaps in the data required to conduct evidence-based biorisk assessments, as described in Blacksell et al. One significant gap is the need for definitive data on M. tuberculosis sample aerosolization to guide the selection of engineering controls for diagnostic procedures. Methods: The literature search focused on five areas: routes of inoculation/modes of transmission, infectious dose, laboratory-acquired infections, containment releases, and disinfection and decontamination methods. Results: The available data regarding biosafety knowledge gaps and existing evidence have been collated and presented in Tables 1 and 2 . The guidance sources on the appropriate use of biosafety cabinets for specific procedures with M. tuberculosis require clarification. Detecting vulnerabilities in the biorisk assessment for respiratory pathogens is essential to improve and develop laboratory biosafety in local and national systems.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

The Biosafety Research Road Map: The Search for Evidence to Support Practices in the Laboratory—Zoonotic Avian Influenza and Mycobacterium tuberculosis

et al. 2023

View full text Add to dashboard Cite

show abstract

“…IAVs and CoVs with single-stranded RNA genomes mutate with much higher rates than double-stranded RNA viruses and DNA viruses (single- or double-stranded) [ 8 ]. Avian host-originated IAVs of H5N1 [ 9 , 10 , 11 ], H7N9 [ 12 , 13 ], and other subtypes [ 14 , 15 ] adapted to mammals or mammalian cells with or without mammalian passages. In particular, domestic pigs and probably other species in Suiformes played a key intermediate host role for all six historic influenza pandemics [ 6 , 16 , 17 , 18 , 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

Risk Assessment of the Possible Intermediate Host Role of Pigs for Coronaviruses with a Deep Learning Predictor

Jiang

Zhang

Kang

et al. 2023

Viruses

View full text Add to dashboard Cite

Swine coronaviruses (CoVs) have been found to cause infection in humans, suggesting that Suiformes might be potential intermediate hosts in CoV transmission from their natural hosts to humans. The present study aims to establish convolutional neural network (CNN) models to predict host adaptation of swine CoVs. Decomposing of each ORF1ab and Spike sequence was performed with dinucleotide composition representation (DCR) and other traits. The relationship between CoVs from different adaptive hosts was analyzed by unsupervised learning, and CNN models based on DCR of ORF1ab and Spike were built to predict the host adaptation of swine CoVs. The rationality of the models was verified with phylogenetic analysis. Unsupervised learning showed that there is a multiple host adaptation of different swine CoVs. According to the adaptation prediction of CNN models, swine acute diarrhea syndrome CoV (SADS-CoV) and porcine epidemic diarrhea virus (PEDV) are adapted to Chiroptera, swine transmissible gastroenteritis virus (TGEV) is adapted to Carnivora, porcine hemagglutinating encephalomyelitis (PHEV) might be adapted to Primate, Rodent, and Lagomorpha, and porcine deltacoronavirus (PDCoV) might be adapted to Chiroptera, Artiodactyla, and Carnivora. In summary, the DCR trait has been confirmed to be representative for the CoV genome, and the DCR-based deep learning model works well to assess the adaptation of swine CoVs to other mammals. Suiformes might be intermediate hosts for human CoVs and other mammalian CoVs. The present study provides a novel approach to assess the risk of adaptation and transmission to humans and other mammals of swine CoVs.

show abstract

“…A major determinant of inter-species transmission, and therefore emerging coronaviruses is receptor-binding capability. This has been comprehensively studied with regard to Influenza A viruses (IAVs) but to a much lesser extent with coronaviruses [18][19][20]. The first coronavirus receptor identified in 1991 was the murine hepatitis virus (MHV) receptor CEACAM1 [21].…”

Section: Introductionmentioning

confidence: 99%

Known Cellular and Receptor Interactions of Animal and Human Coronaviruses: A Review

Everest

Stevenson-Leggett

Bailey

et al. 2022

Viruses

Self Cite

View full text Add to dashboard Cite

This article aims to review all currently known interactions between animal and human coronaviruses and their cellular receptors. Over the past 20 years, three novel coronaviruses have emerged that have caused severe disease in humans, including SARS-CoV-2 (severe acute respiratory syndrome virus 2); therefore, a deeper understanding of coronavirus host–cell interactions is essential. Receptor-binding is the first stage in coronavirus entry prior to replication and can be altered by minor changes within the spike protein—the coronavirus surface glycoprotein responsible for the recognition of cell-surface receptors. The recognition of receptors by coronaviruses is also a major determinant in infection, tropism, and pathogenesis and acts as a key target for host-immune surveillance and other potential intervention strategies. We aim to highlight the need for a continued in-depth understanding of this subject area following on from the SARS-CoV-2 pandemic, with the possibility for more zoonotic transmission events. We also acknowledge the need for more targeted research towards glycan–coronavirus interactions as zoonotic spillover events from animals to humans, following an alteration in glycan-binding capability, have been well-documented for other viruses such as Influenza A.

show abstract

The Emergence and Zoonotic Transmission of H10Nx Avian Influenza Virus Infections

Abstract: Avian influenza viruses pose a continuous threat to both poultry and human health, with significant economic impact. The ability of viruses to reassort and jump the species barrier into mammalian hosts generates a constant pandemic threat.

Cited by 8 publications

References 108 publications

The Biosafety Research Road Map: The Search for Evidence to Support Practices in the Laboratory—Zoonotic Avian Influenza and Mycobacterium tuberculosis

The Biosafety Research Road Map: The Search for Evidence to Support Practices in the Laboratory—Zoonotic Avian Influenza and Mycobacterium tuberculosis

Risk Assessment of the Possible Intermediate Host Role of Pigs for Coronaviruses with a Deep Learning Predictor

Known Cellular and Receptor Interactions of Animal and Human Coronaviruses: A Review

Contact Info

Product

Resources

About