The Emergence of a Circadian Pattern in Respiratory Rates: Comparison between Control Infants and Subsequent Siblings of SIDS

Hoppenbrouwers, Toke; Jensen, Debra K; Hodgman, Joan E.; Harper, Ronald M.; Sterman, M. B.

doi:10.1203/00006450-198004000-00018

Cited by 22 publications

(7 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…More consolidated wake periods, longer latencies to REM sleep, a rapid maturation of REM sleep cyclicity, and lower REM sleep amounts are reported in infants at risk for SIDS (15,27,37). Infants at risk for SIDS also show precocious circadian organization in sleep (30) and sleep respiratory patterns (18) and more rapid maturation in sleep EEGs compared with agematched infants not at risk for SIDS (29,37). Although the relationship between maturational rates and SIDS is not yet clear (4,5,13), our results are consistent with several findings in humans and suggest that SIDS is associated with an accelerated development of sleep and wake that may be induced or amplified by maternal smoking.…”

Section: Discussionmentioning

confidence: 99%

Prenatal nicotine alters vigilance states and AchR gene expression in the neonatal rat: implications for SIDS

Frank

Srere

Ledezma

et al. 2001

American Journal of Physiology-Regulatory, Integrative and Comp

View full text Add to dashboard Cite

Maternal smoking is a major risk factor for sudden infant death syndrome (SIDS). The mechanisms by which cigarette smoke predisposes infants to SIDS are not known. We examined the effects of prenatal nicotine exposure on sleep/wake ontogenesis and central cholinergic receptor gene expression in the neonatal rat. Prenatal nicotine exposure transiently increased sleep continuity and accelerated sleep/wake ontogeny in the neonatal rat. Prenatal nicotine also upregulated nicotinic and muscarinic cholinergic receptor mRNAs in brain regions involved in regulating vigilance states. These findings suggest that the nicotine contained in cigarette smoke may predispose human infants to SIDS by interfering with the normal maturation of sleep and wake.

show abstract

Section: Discussionmentioning

confidence: 99%

Prenatal nicotine alters vigilance states and AchR gene expression in the neonatal rat: implications for SIDS

Frank

Srere

Ledezma

et al. 2001

American Journal of Physiology-Regulatory, Integrative and Comp

View full text Add to dashboard Cite

show abstract

“…In babies, the mechanism controlling the homeostatic regulation is probably not yet fully matured. An incomplete maturation of the control mechanisms by the autonomic and central nervous system is suggested by the variability of the main physiological functions observed during the period of emergence of the circadian rhythm (20,29). The stability of the circadian rhythm is not achieved before 6 to 8 months of age and sometimes later (38).…”

Section: Discussionmentioning

confidence: 99%

“…The period between 6 and 12 weeks of age appears to be critical in the development of many physiological functions: circadian rhythm (25), body temperature [Jundell as cited by Minors and Waterhouse (29)], heart rate (14,16), respiratory rhythm (7,20), electrodermogram (6), as well as sleep organization (30).…”

mentioning

confidence: 99%

Nocturnal Sleep Organization in Infants “at Risk” for Sudden Infant Death Syndrome

et al. 1984

View full text Add to dashboard Cite

SummaryNocturnal sleep organization was compared in normal infants and those "at risk" for sudden infant death syndrome (SIDS) (siblings and near-miss infants). Before 12 weeks of age, sleep modifications were observed in "at risk" infants. During their sleep they had a smaller percentage of intervening wakefulness with a higher amount of active sleep. Quiet and active sleep episodes had longer durations resulting in a longer sleep cycle. After 12 weeks, sleep organization tended to normalize. This fact is discussed as a possible factor for a SIDS event: a higher arousal threshold could play a critical role if homeostasy is disturbed during sleep, mainly at an age when the homeostatic control is not fully established. Abbreviations SIDS, sudden infant death syndrome W, wakefulness AS, active sleep QS, quiet sleep TS, transitional sleep C, control S, siblings NM, near-miss Polygraphic recordings in infants "at risk" for SIDS have been extensively carried out since the first Steinschneider paper (37). This author hypothesized a relationship between SIDS and apnea occurring during sleep. Therefore, most studies since then have been devoted to physiological functions during sleep such as respiratory, cardiovascular, and autonomic systems, gastrooesophageal reflux, etc. as reviewed by Hoppenbrouwers and Hodgman (19) and Kelly and Shannon (24).Sleep organization with relation to SIDS has only been taken into account in the past few years (4,12,15,31). The period between 6 and 12 weeks of age appears to be critical in the development of many physiological functions: circadian rhythm (25), body temperature [Jundell as cited by Minors and Waterhouse (29)], heart rate (14, 16), respiratory rhythm (7, 20), electrodermogram (6), as well as sleep organization (30).The aim of the present study is to compare the sleep organization of normal and "at risk" infants of about the same age corresponding to the maximum frequency of SIDS events. MATERIALS A N D METHODSNocturnal sleep organization was studied in 77 infants ages between 4 weeks and 12 months (35 boys, 42 girls). The population was distributed as follows (Table 1). There were 19 control infants (8 boys, 1 1 girls) having no pathological antecedents either personally or within the immediate family. Fifty-eight infants were "at risk" for SIDS divided into 24 siblings (9 boys, 15 girls) of an infant who died as a result of SIDS but who themselves had no personal pathology and 34 near-miss infants (18 boys, 16 girls) having suffered one or more episodes of unexplained apneawith or cyanosis necessitating vigorous stimulations or mouth to mouth resuscitation for survival.All these children were full-term babies with Apgar scores and birth weight in the normal range. Most of them had been hospitalized for at least 2 days prior to the recording session whereas only a few came directly from home in which case the mother was present in the laboratory during the entire recording night and was responsible for feedings.The 77 nocturnal polygraphic records analyzed in this study corre...

show abstract

“…Whatever biologic priorities and functions are satisfied during the initial hours of sleep, in children it is apparently important that such activities proceed with minimal interruption. One consequence of this overriding of arousal mechanisms is a compromised capability during sleep to respond to stimuli-endogenous and exogenous-some of which may signal potentially life-threatening events e.g., respiratory distress (10,12,13,14) or signals from emergency alarm devices (21,25). Clearly, further investigation into factors underlying this sleep-related functional debilitation in children is warranted.…”

Section: Discussionmentioning

confidence: 99%

Failure of High Intensity Auditory Stimuli to Affect Behavioral Arousal in Children during the First Sleep Cycle

Busby

Pivik

1983

Pediatr Res

View full text Add to dashboard Cite

The Emergence of a Circadian Pattern in Respiratory Rates: Comparison between Control Infants and Subsequent Siblings of SIDS

Cited by 22 publications

References 14 publications

Prenatal nicotine alters vigilance states and AchR gene expression in the neonatal rat: implications for SIDS

Prenatal nicotine alters vigilance states and AchR gene expression in the neonatal rat: implications for SIDS

Nocturnal Sleep Organization in Infants “at Risk” for Sudden Infant Death Syndrome

Failure of High Intensity Auditory Stimuli to Affect Behavioral Arousal in Children during the First Sleep Cycle

Contact Info

Product

Resources

About