The emergence of animal models of chronic pain and logistical and methodological issues concerning their use

Coderre, Terence J.; Laferrière, André

doi:10.1007/s00702-019-02103-y

Cited by 24 publications

(12 citation statements)

References 156 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Neuropathic pain affects 7-10% of the general population and results from a lesion affecting peripheral or central neurons (Colloca et al 2017). Etiology for chronic neuropathic pain is multifactorial, and this has led to the development of several animal models (Coderre and Laferriere 2019;Kumar et al 2018), potentially associated with different neuronal circuits. Neuronal populations engaged in the DH during neuropathic pain were historically revealed using immunohistochemistry directed against immediate-early genes (a.k.a.…”

Section: Persistent Neuropathic Painmentioning

confidence: 99%

“…Several animal models have been developed to study specific pathologies associated with inflammatory pain, such as multiple sclerosis (MS) (Procaccini et al 2015) or migraine (Chou and Chen 2018;Dallel et al 2018), but most common models of inflammatory pain involve injections of agents such as capsaicin, formalin, mustard oil, carrageenan or complete Freund's adjuvant into the skin, muscle, visceral organs or joints (Coderre and Laferriere 2019;Gregory et al 2013). Virtually, all of these models are associated with immediate CMA, with some lasting longer due to chronic inflammation, such as the carrageenan and CFA pain models for which CMA can persist from days to several weeks.…”

Section: Persistent Inflammatory Painmentioning

confidence: 99%

See 1 more Smart Citation

Recent advances in our understanding of the organization of dorsal horn neuron populations and their contribution to cutaneous mechanical allodynia

2020

View full text Add to dashboard Cite

The dorsal horns of the spinal cord and the trigeminal nuclei in the brainstem contain neuron populations that are critical to process sensory information. Neurons in these areas are highly heterogeneous in their morphology, molecular phenotype and intrinsic properties, making it difficult to identify functionally distinct cell populations, and to determine how these are engaged in pathophysiological conditions. There is a growing consensus concerning the classification of neuron populations, based on transcriptomic and transductomic analyses of the dorsal horn. These approaches have led to the discovery of several molecularly defined cell types that have been implicated in cutaneous mechanical allodynia, a highly prevalent and difficult-to-treat symptom of chronic pain, in which touch becomes painful. The main objective of this review is to provide a contemporary view of dorsal horn neuronal populations, and describe recent advances in our understanding of on how they participate in cutaneous mechanical allodynia.

show abstract

Section: Persistent Neuropathic Painmentioning

confidence: 99%

Section: Persistent Inflammatory Painmentioning

confidence: 99%

Recent advances in our understanding of the organization of dorsal horn neuron populations and their contribution to cutaneous mechanical allodynia

2020

View full text Add to dashboard Cite

show abstract

“…Neuropathic pain is defined as pain resulting from a lesion or disease of the somatosensory system ( Scholz et al, 2019 ). Numerous neuropathic pain rodent models have been developed of both central and peripheral neuropathies – see for review ( Coderre and Laferriere, 2020 , Leite-Almeida et al, 2015 ), and references within. Despite the diversity of models and its widespread use in different experimental contexts they are clearly underrepresented in the pool of selected articles.…”

Section: Resultsmentioning

confidence: 99%

Diet, body weight and pain susceptibility – A systematic review of preclinical studies

Miranda

Campos

Leite‐Almeida

2021

Neurobiology of Pain

View full text Add to dashboard Cite

Highlights Obesity has been associated with increased susceptibility to chronic pain. Dietary and genetic models of obesity have been used to study this association. Allodynia is a common finding but alterations in nociception were inconsistent across studies. In subacute/chronic models, nocifencive behaviors were increased and/or sustained. Reviewed studies are overall consonant with the clinical literature.

show abstract

“…Behavioral responses to sensory stimuli are widely used as surrogates of presumed pain perception in diabetic rodents, with all the attendant caveats that apply to use of such evoked response tests when used to define other models of neuropathic pain [123,124]. The physiology of diabetes brings additional concerns that muscle wasting and protein glycation in skin can also modify behavioral responses.…”

Section: Sensory Perception and Painmentioning

confidence: 99%

Lost in Translation? Measuring Diabetic Neuropathy in Humans and Animals

2021

View full text Add to dashboard Cite

The worldwide diabetes epidemic is estimated to currently afflict almost 500 million persons. Long-term diabetes damages multiple organ systems with the blood vessels, eyes, kidneys and nervous systems being particularly vulnerable. These complications of diabetes reduce lifespan, impede quality of life and impose a huge social and economic burden on both the individual and society. Peripheral neuropathy is a debilitating complication that will impact over half of all persons with diabetes. There is no treatment for diabetic neuropathy and a disturbingly long history of therapeutic approaches showing promise in preclinical studies but failing to translate to the clinic. These failures have prompted re-examination of both the animal models and clinical trial design. This review focuses on the functional and structural parameters used as indices of peripheral neuropathy in preclinical and clinical studies and the extent to which they share a common pathogenesis and presentation. Nerve conduction studies in large myelinated fibers have long been the mainstay of preclinical efficacy screening programs and clinical trials, supplemented by quantitative sensory tests. However, a more refined approach is emerging that incorporates measures of small fiber density in the skin and cornea alongside these traditional assays at both preclinical and clinical phases.

show abstract

The emergence of animal models of chronic pain and logistical and methodological issues concerning their use

Cited by 24 publications

References 156 publications

Recent advances in our understanding of the organization of dorsal horn neuron populations and their contribution to cutaneous mechanical allodynia

Recent advances in our understanding of the organization of dorsal horn neuron populations and their contribution to cutaneous mechanical allodynia

Diet, body weight and pain susceptibility – A systematic review of preclinical studies

Lost in Translation? Measuring Diabetic Neuropathy in Humans and Animals

Contact Info

Product

Resources

About