The Emergence of Carbapenem Resistant Enterobacteriaceae Producing GIM-1 and SIM-1 Clinical Isolates in Khartoum-Sudan

Bayoumi, Magdi; Hamid, Omnia

doi:10.2147/idr.s365983

Cited by 4 publications

(1 citation statement)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…NDM-1 (New Delhi metallo-β-lactamase) is the most frequently reported metallo-β-lactamase enzymes including [94] , VIM (verona integron-encoded metallo-β-lactamase), IMP (imipenem-resistant pseudomonas) type carbapenemase, SIM (Seoul imipenemase), and GIM (German imipenemase). NDM coding genes are dominant in K. pneumoniae isolates [95] , [96] .…”

Section: Resistance Mechanisms In K Pneumoniaementioning

confidence: 99%

Molecular typing methods & resistance mechanisms of MDR Klebsiella pneumoniae

2023

View full text Add to dashboard Cite

<abstract> The emergence and transmission of carbapenem-resistant <italic>Klebsiella pneumoniae</italic> (CRKP) have been recognized as a major public health concern. Here, we investigated the molecular epidemiology and its correlation with the mechanisms of resistance in CRKP isolates by compiling studies on the molecular epidemiology of CRKP strains worldwide. CRKP is increasing worldwide, with poorly characterized epidemiology in many parts of the world. Biofilm formation, high efflux pump gene expression, elevated rates of resistance, and the presence of different virulence factors in various clones of <italic>K. pneumoniae</italic> strains are important health concerns in clinical settings. A wide range of techniques has been implemented to study the global epidemiology of CRKP, such as conjugation assays, 16S-23S rDNA, string tests, capsular genotyping, multilocus sequence typing, whole-genome sequencing-based surveys, sequence-based PCR, and pulsed-field gel electrophoresis. There is an urgent need to conduct global epidemiological studies on multidrug-resistant infections of <italic>K. pneumoniae</italic> across all healthcare institutions worldwide to develop infection prevention and control strategies. In this review, we discuss different typing methods and resistance mechanisms to explore the epidemiology of <italic>K. pneumoniae</italic> pertaining to human infections. </abstract>

show abstract

Section: Resistance Mechanisms In K Pneumoniaementioning

confidence: 99%

Molecular typing methods & resistance mechanisms of MDR Klebsiella pneumoniae

2023

View full text Add to dashboard Cite

show abstract

Relative inhibitory activities of the broad-spectrum β-lactamase inhibitor taniborbactam against metallo-β-lactamases

Le Terrier,

Viguier,

Nordmann

et al. 2024

Antimicrob Agents Chemother

View full text Add to dashboard Cite

Taniborbactam (TAN) is a novel broad-spectrum β-lactamase inhibitor with significant activity against subclass B1 metallo-β-lactamases (MBLs). Here, we showed that TAN exhibited an overall excellent activity against B1 MBLs including most NDM- and VIM-like as well as SPM-1, GIM-1, and DIM-1 enzymes, but not against SIM-1. Noteworthy, VIM-1-like enzymes (particularly VIM-83) were less inhibited by TAN than VIM-2-like. Like NDM-9, NDM-30 (also differing from NDM-1 by a single amino acid substitution) was resistant to TAN.

show abstract

Relative inhibitory activities of the broad-spectrum β-lactamase inhibitor xeruborbactam in comparison with taniborbactam against metallo-β-lactamases produced in Escherichia coli and Pseudomonas aeruginosa

Le Terrier,

Freire,

Viguier

et al. 2024

Antimicrob Agents Chemother

View full text Add to dashboard Cite

Xeruborbactam is a newly developed β-lactamase inhibitor designed for metallo-β-lactamases (MBLs). This study assessed the relative inhibitory properties of this novel inhibitor in comparison with another MBL inhibitor, namely taniborbactam (TAN), against a wide range of acquired MBL produced either in Escherichia coli or Pseudomonas aeruginosa . As observed with taniborbactam, the combination of xeruborbactam (XER) with β-lactams, namely, ceftazidime, cefepime and meropenem, led to significantly decreased MIC values for a wide range of B1-type MBL-producing E. coli , including most recombinant strains producing NDM, VIM, IMP, GIM-1, and DIM-1 enzymes. Noteworthily, while TAN-based combinations significantly reduced MIC values of β-lactams for MBL-producing P. aeruginosa recombinant strains, those with XER were much less effective. We showed that this latter feature was related to the MexAB-OprM efflux pump significantly impacting MIC values when testing XER-based combinations in P. aeruginosa . The relative inhibitory concentrations (IC 50 values) were similar for XER and TAN against NDM and VIM enzymes. Noteworthily, XER was effective against NDM-9, NDM-30, VIM-83, and most of IMP enzymes, although those latter enzymes were considered resistant to TAN. However, no significant inhibition was observed with XER against IMP-10, SPM-1, and SIM-1 as well as the representative subclass B2 and B3 enzymes, PFM-1 and AIM-1. The determination of the constant inhibition ( K i ) of XER revealed a much higher value against IMP-10 than against NDM-1, VIM-2, and IMP-1. Hence, IMP-10 that differs from IMP-1 by a single amino-acid substitution (Val67Phe) can, therefore, be considered resistant to XER.

show abstract

The Emergence of Carbapenem Resistant Enterobacteriaceae Producing GIM-1 and SIM-1 Clinical Isolates in Khartoum-Sudan

Cited by 4 publications

References 22 publications

Molecular typing methods & resistance mechanisms of MDR <i>Klebsiella pneumoniae</i>

Molecular typing methods & resistance mechanisms of MDR <i>Klebsiella pneumoniae</i>

Relative inhibitory activities of the broad-spectrum β-lactamase inhibitor taniborbactam against metallo-β-lactamases

Relative inhibitory activities of the broad-spectrum β-lactamase inhibitor xeruborbactam in comparison with taniborbactam against metallo-β-lactamases produced in Escherichia coli and Pseudomonas aeruginosa

Contact Info

Product

Resources

About

The Emergence of Carbapenem Resistant Enterobacteriaceae Producing GIM-1 and SIM-1 Clinical Isolates in Khartoum-Sudan

Cited by 4 publications

References 22 publications

Molecular typing methods &amp; resistance mechanisms of MDR <i>Klebsiella pneumoniae</i>

Molecular typing methods &amp; resistance mechanisms of MDR <i>Klebsiella pneumoniae</i>

Relative inhibitory activities of the broad-spectrum β-lactamase inhibitor taniborbactam against metallo-β-lactamases

Relative inhibitory activities of the broad-spectrum β-lactamase inhibitor xeruborbactam in comparison with taniborbactam against metallo-β-lactamases produced in Escherichia coli and Pseudomonas aeruginosa

Contact Info

Product

Resources

About

Molecular typing methods & resistance mechanisms of MDR <i>Klebsiella pneumoniae</i>

Molecular typing methods & resistance mechanisms of MDR <i>Klebsiella pneumoniae</i>