The emergence of clinical resistance to tigecycline

Sun, Yan; Cai, Yun; Liu, Xu; Bai, Nan; Liang, Beibei; Wang, Rui

doi:10.1016/j.ijantimicag.2012.09.005

Cited by 164 publications

(133 citation statements)

References 80 publications

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“…Our results suggest that resistance to tigecycline is not so rare and it represents an emerging problem for the bacterial treatment in veterinary and human medicine, as supposed by other authors [37][38][39].…”

Section: Discussionsupporting

confidence: 73%

Salmonella infection in healthy pet reptiles: Bacteriological isolation and study of some pathogenic characters

Bertelloni¹,

Chemaly²,

Cerri³

et al. 2016

Acta Microbiologica et Immunologica Hungarica

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The fecal samples from 213 captive reptiles were examined, and 29 (13.61%) Salmonella enterica isolates were detected: 14/62 (22.58%) from chelonians, 14/135 (10.37%) from saurians, and 1/16 (6.25%) from ophidians. The isolates were distributed among 14 different serotypes: Miami, Ebrie, Hermannsweder, Tiergarten, Tornov, Pomona, Poona, Goteborg, Abaetetube, Nyanza, Kumasi, Typhimurium, 50:b:z 6 , 9,12:z 29 :1,5, and a non-motile serotype with antigenic formula 1,4,[5],12:-:-. Salmonella typhimurium and 50:b:z 6 isolates showed the spv plasmid virulence genes, responsible of the capability to induce extra-intestinal infections. In some cases, pulsed field gel electrophoresis revealed different profiles for the strains of the same serotypes, showing different origins, whereas a common source of infection was supposed when one pulsotype had been observed for isolates of a serovar. Twentyseven (93.10%) isolates showed resistance to one or more antibiotics. Ceftazidime was active to all the tested isolates, whereas the highest percentages of strains were no susceptible to tigecycline (93.10%), streptomycin (89.66%), and sulfonamide (86.21%).

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Section: Discussionsupporting

confidence: 73%

Salmonella infection in healthy pet reptiles: Bacteriological isolation and study of some pathogenic characters

Bertelloni¹,

Chemaly²,

Cerri³

et al. 2016

Acta Microbiologica et Immunologica Hungarica

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show abstract

“…Tigecycline is a bacteriostatic antibiotic active against a broad range of bacteria, with only few naturally resistant exceptions [20]. Instead, our result suggests that resistance to tigecycline is not so uncommon and could be a new threat in the therapy of infections.…”

Section: Discussionmentioning

confidence: 73%

Antimicrobial resistance in Enterococcus strains isolated from healthy domestic dogs

Bertelloni

Salvadori

Lotti

et al. 2016

Acta Microbiologica et Immunologica Hungarica

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Enterococci are opportunistic bacteria that cause severe infections in animals and humans, capable to acquire, express, and transfer antimicrobial resistance. Susceptibility to 21 antimicrobial agents was tested by the disk diffusion method in 222 Enterococcus spp. strains isolated from the fecal samples of 287 healthy domestic dogs. Vancomycin and ampicillin minimum inhibitory concentrations (MICs) and high-level aminoglycoside resistance (HLAR) tests were also performed. Isolates showed resistance mainly to streptomycin (88.7%), neomycin (80.6%), and tetracycline (69.4%). Forty-two (18.9%) isolates showed an HLAR to streptomycin and 15 (6.7%) to gentamicin. Vancomycin and ampicillin MIC values showed 1 and 18 resistant strains, respectively. One hundred and thirty-six (61.2%) strains were classified as multidrug resistant and six (2.7%) strains as possibly extensively drug-resistant bacteria. Enterococcus faecium and Enterococcus faecalis were the most prevalent antimicrobial resistant species. Companion animals, which often live in close contact with their owners and share the same environment, represent a serious source of enterococci resistant to several antibiotics; for this reason, they may be a hazard for public health by providing a conduit for the entrance of resistance genes into the community.

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“…However, clinical resistance to tigecycline has been increasingly reported worldwide since 2007 (6) . Our study involving three hospitals showed that the tigecycline-resistance rate has been increasing from year to year.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, tigecycline has attracted much attention in the research community and is considered the last resort to treat infections caused by MDR bacteria. However, due to the increased use of this drug, tigecycline resistance is now rapidly emerging (6) . Various studies have indicated that tigecycline resistance is associated with the overexpression of efflux systems located in the bacterial cell wall, particularly members of the resistancenodulation-cell division (RND) family, which includes the AdeABC, AdeIJK, and AdeFGH efflux systems in A. baumannii and the AcrAB-TolC efflux system in K. pneumoniae (6) .…”

mentioning

confidence: 99%

“…However, due to the increased use of this drug, tigecycline resistance is now rapidly emerging (6) . Various studies have indicated that tigecycline resistance is associated with the overexpression of efflux systems located in the bacterial cell wall, particularly members of the resistancenodulation-cell division (RND) family, which includes the AdeABC, AdeIJK, and AdeFGH efflux systems in A. baumannii and the AcrAB-TolC efflux system in K. pneumoniae (6) . However, the exact mechanisms of resistance have not yet been clearly elucidated, and the relationship between the level of expression of efflux pumps and the minimal inhibitory concentration (MIC) of tigecycline has not been established.…”

mentioning

confidence: 99%

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Over expression of AdeABC and AcrAB-TolC efflux systems confers tigecycline resistance in clinical isolates of Acinetobacter baumannii and Klebsiella pneumoniae

Yin

Ziyun

Zhang

et al. 2016

Rev. Soc. Bras. Med. Trop.

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The emergence of clinical resistance to tigecycline

Cited by 164 publications

References 80 publications

Salmonella infection in healthy pet reptiles: Bacteriological isolation and study of some pathogenic characters

Salmonella infection in healthy pet reptiles: Bacteriological isolation and study of some pathogenic characters

Antimicrobial resistance in Enterococcus strains isolated from healthy domestic dogs

Over expression of AdeABC and AcrAB-TolC efflux systems confers tigecycline resistance in clinical isolates of Acinetobacter baumannii and Klebsiella pneumoniae

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