The emergence of drug resistance in tumours: a characteristic which may be exploited therapeutically

Tattersall, Martin H. N.

doi:10.1038/bjc.1973.49

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1974

2011

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Cited by 6 publications

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“…Many cell types for instance acquire resistance to methotrexate by the induction of high levels of folate reductase enzymes. These enzymes activate the anti-metabolite homofolates and it has been suggested that they should be used after treatment with methotrexate (Tattersall 1973). 5-Fluorocytosine is inactive in man and non-toxic and is used as an anti-fungal agent.…”

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confidence: 99%

“…Therefore, in patients with acute myeloid leukaemia and with acquired resistance to cytosine arabinoside, there may be a selective activation of 5-fluorocytosine in tumour cells to a cytotoxic derivative. It has been suggested that a logical combination in the treatment of this malignancy would be a course of 5-fluorocytosine following an infusion of cytosine arabinoside, especially if there was evidence of an increased level of cytidine deaminase in the bone marrow (Tattersall 1973).…”

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