The field of healthcare informatics is rapidly evolving. The new models and protocols of medical information system (MIS) are developed. Despite obvious advantages and benefits, practical application of MIS in everyday practice is slow. Cloud computing have emerged as an important new field, distinguished from conventional distributed computing by its focus on large-scale sharing, innovative applications, and, in some cases, high-performance orientation. “Cloud computing” the authors are going to define as flexible, secure, coordinated resource sharing among dynamic collections of individuals, institutions, and resources. Cloud computing is a new way of delivering computing resources and services. It is plausible, that this technology has more potential and can improve health care services, benefit health care research, and change the face of health information technology. This can be solution for widespread and effective implementation of the medical information system. The present article will discuss the application of cloud computing for the medical information system practical usage. The ideal of healthcare in the information age must be to create knowledge from medical information and less time managing medical information and data. The application of easily available and adaptable technology and improvement of the infrastructure conditions is the basis for medical informatics applications. The usage of MIS holds the potential to improve, develop and realize medical service in the effective and comprehensive mode.