The emergence of mecC methicillin-resistant Staphylococcus aureus

Paterson, Gavin K.; Harrison, Ewan M.; Holmes, Mark A.

doi:10.1016/j.tim.2013.11.003

Cited by 378 publications

(342 citation statements)

References 50 publications

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“…This divergence indicates that it had an independent evolution, although it is not yet known how it evolved. It also indicates that although the earliest strain found was from 1975, this type may have been circulating for an even longer period [97,98]. This appears similar to what is observed for mecA-carrying SCCmec elements in coagulasenegative staphylococci; however, for mecC of course fewer strains are available to date, and the diversity is still difficult to assess.…”

Section: Scc Mec Type XI Mecc-carrying Mrsa From Animalssupporting

confidence: 60%

“…It was discovered because it was negative on mecA PCR but phenotypically resistant. Although this SCCmec type is associated mainly with CC130, it also has been found in CC1943 and CC425 as well as in many other CCs, including CC599 and CC59 [97,98,99].…”

Section: Scc Mec Type XI Mecc-carrying Mrsa From Animalsmentioning

confidence: 91%

“…The livestock animal species involved are mainly dairy cattle, and these strains have not been recovered from pigs or poultry so far. Other animals involved include sea mammals, pet animals, wildlife (birds and mammals), and zoo animals [97][98][99][101][102][103][104][105][106]. Of note, the ST130 strains carrying SCCmec type XI are likely to be zoonotic and to cause infections in animals [98,107].…”

Section: Scc Mec Type XI Mecc-carrying Mrsa From Animalsmentioning

confidence: 99%

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Livestock-Associated MRSA and Its Current Evolution

Butaye

Argudín

Smith

2016

Curr Clin Micro Rpt

116

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Livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) is a relatively recent phenomenon in veterinary medicine. Although in the beginning it was restricted to a single clonal complex (CC), CC398, it has expanded into several clonal complexes, and the diversity of subtypes in the clonal complexes is increasing also. The prevalence of each type is determined somewhat geographically; for instance, the most prevalent clonal complex in Europe is CC398, whereas in Asia, it is CC9. Although few data exist regarding North America, the situation appears to be mixed there. The SCCmec cassettes detected in LA-MRSA are limited mainly to SCCmec IVa and SCCmec V, although non-typeable cassettes and SCCmec type XI, containing mecC, also have been found.The source of the SCCmec in LA-MRSA was discovered to be animals. In searching from which bacteria the SCCmec cassettes in LA-MRSA have been transferred, the most obvious species to consider are the methicillin-resistant non-S. aureus staphylococci (MRNaS). However, very few data are available from those species in animals, and the data that do exist are not detailed enough to determine the origin. Nevertheless, similar cassettes were found in MRNaS, indicating a possible origin that needs to be investigated further.

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Section: Scc Mec Type XI Mecc-carrying Mrsa From Animalssupporting

confidence: 60%

Section: Scc Mec Type XI Mecc-carrying Mrsa From Animalsmentioning

confidence: 91%

Section: Scc Mec Type XI Mecc-carrying Mrsa From Animalsmentioning

confidence: 99%

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Livestock-Associated MRSA and Its Current Evolution

Butaye

Argudín

Smith

2016

Curr Clin Micro Rpt

116

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“…Resistance to β-lactams in S. aureus is caused by the production of the modified penicillin-binding protein 2a (PBP2a or PBP2'), which is encoded by the mecA or mecC gene located on the mobile genetic element SCCmec (Paterson et al, 2014). Based on multilocus sequence typing (MLST) and sequencing of repeating units within the staphylococcal protein A (spa) gene, MRSA isolates can be assigned to clonal complexes (CC) and spa types (t-types), which allows their classification as hospital-associated (HA)-, community-associated (CA)-or livestock-associated (LA)-MRSA.…”

Section: Introductionmentioning

confidence: 99%

Characteristics of ESBL-producing Enterobacteriaceae and Methicillinresistant Staphylococcus aureus (MRSA) isolated from Swiss and imported raw poultry meat collected at retail level

Zogg

Zurfluh

Nüesch‐Inderbinen

et al. 2016

SAT

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This study was conducted to investigate the occurrence and genetic characteristics of extended spectrum -lactamase (ESBL) and methicillin-resistant Staphylococcus aureus (MRSA) in 80 samples of Swiss (n=36) and imported (n=44) raw chicken meat collected at retail level. In addition, ESBLproducers were screened for the presence of the plasmid-mediated colistin resistance gene mcr-1. Countries of import included Argentina (n=2), Austria (n=1), Brazil (n=3), Denmark (n=5), France (n=1), Germany (n=13), Hungary (n=5), Italy (n=8), and Slovenia (n=6). Forty ESBL-producing E. coli strains were isolated from 33 (41.3%) of the 80 samples, comprising seven (19.4%) of the Swiss and 26 (59%) of the imported samples. The most common blaESBL among the isolates were blaCTX-M-1 (n=14) and blaSHV-12 (n=16). Other genes comprised blaTEM-52 (n=4), blaCTX-M-2 (n=3), blaCTX-M-8 (n=1), blaCTX-M-14 (n=1) and a novel blaCTX-M-14-like variant (n=1). Two ESBL-producers isolated from samples from Germany (n=1) and Italy (n=1) tested additionally positive for the plasmid-mediated colistin resistance gene mcr-1. Six (7.5%) samples, all imported from Germany, were found to contain MRSA. Three isolates belonged to the livestock-associated CC398-MRSA-V-t034, and 3 to CC9-MRSA-IV-t13177, described here for the first time in chicken meat. AbstractThis study was conducted to investigate the occurrence and genetic characteristics of extended spectrum β-lactamase (ESBL) and methicillin-resistant Staphylococcus aureus (MRSA) in 80 samples of Swiss (n=36) and imported (n= 44) raw chicken meat collected at retail level. In addition, ESBL-producers were screened for the presence of the plasmid-mediated colistin resistance gene mcr-1. Countries of import included Argentina (n=2), Austria (n=1), Brazil (n=3), Denmark (n=5), France (n=1), Germany (n=13), Hungary (n=5), Italy (n=8), and Slovenia (n= 6). Forty ESBL-producing E. coli strains were isolated from 33 (41.3%) of the 80 samples, comprising seven (19.4%) of the Swiss and 26 (59%) of the imported samples. The most common blaESBL among the isolates were blaCTX-M-1 (n=14) and blaSHV-12 (n=16). Other genes comprised blaTEM-52 (n= 4), blaCTX-M-2 (n=3), blaCTX-M-8 (n=1), blaCTX-M-14 (n=1) and a novel blaCTX-M-14-like variant (n=1). Two ESBL-producers isolated from samples from Germany (n=1) and Italy (n=1) tested additionally positive for the plasmid-mediated colistin resistance gene mcr-1. Six (7.5%) samples, all imported from Germany, were found to contain MRSA. Three isolates belonged to the livestock-associated CC398-MRSA-V-t034, and 3 to CC9-MRSA-IV-t13177, described here for the first time in chicken meat. . Bei 2 ESBL-Bildnern von Proben aus Deutschland (n=1) und Italien (n=1) wurde zusätzlich das mcr-1, ein plasmid-kodiertes Resistenzgen gegen Colistin, nachgewiesen. Sechs Proben (7.5%), welche alle aus Deutschland stammten, waren MRSA positiv. Genotypisierung ordnete 3 der Stämme dem Nutztier-assoziiereten Klon CC398-MRSA-V-t034, und 3 weitere dem CC9-MRSA-IV-t13177 zu. Letzterer w...

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“…As already suggested for the mecA gene, we can probably infer that the origin of the mecC gene is also among the CoNS (Tsubakishita et al, 2010;Couto et al, 2013). Although mecC gene detection is rare and reported only in Europe so far, this gene is a potential diagnosis problem and triggers several issues for future studies (Paterson, Harrison, Holmes, 2014).…”

Section: Assessment Of Methicillin-resistant Coagulasenegative Staphymentioning

confidence: 99%

Antimicrobial susceptibility profile and research of mec A and erm genes in coagulase-negative staphylococci isolated from platelet concentrates bags

Martini

Hörner

Graichen³

2017

Braz. J. Pharm. Sci.

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In recent years, several studies have described the clinical impact of bacterial infection associated with transfusion of platelet concentrates (PCs). Among the blood components, PCs are responsible for the highest rates of bacterial contamination as well as septic transfusion reactions. We assessed antimicrobial susceptibility profile, resistance to methicillin (MRCoNS), and resistance to macrolides, lincosamides and streptogramins of group B (MLS B ) of 16 coagulase-negative staphylococci (CoNS) isolates from an investigation in 691 PCs bags. We then compared conventional and automated phenotypic methods, disc diffusion test (DD) and VITEK® 2, respectively as well as phenotypic and genotypic methods (Polymerase Chain Reaction -PCR). All CoNS were susceptible to vancomycin. The disc diffusion test characterized 18.75% as MRCoNS and 37.5% with inducible resistance to MLS B (iMLS B ), and with VITEK® 2, 6.3% and 31.25%, respectively. The mecA gene was detected in 18.75% and the erm gene in 31.25% of the isolates. In this study, we found equal percentage values between presence of the mecA gene by PCR and resistance to methicillin using cefoxitin by DD test, evidence of the erm gene by PCR, and iMLS B resistance by automation (VITEK® 2). Moreover, we identified three strains with beta-lactamase overproduction, and the occurrence of a bigger mistake was verified when automation was compared with DD test. And we observed that D-test was the most reliable for the detection of iMLS B resistance in Staphylococcus sp.

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The emergence of mecC methicillin-resistant Staphylococcus aureus

Cited by 378 publications

References 50 publications

Livestock-Associated MRSA and Its Current Evolution

Livestock-Associated MRSA and Its Current Evolution

Characteristics of ESBL-producing Enterobacteriaceae and Methicillinresistant Staphylococcus aureus (MRSA) isolated from Swiss and imported raw poultry meat collected at retail level

Antimicrobial susceptibility profile and research of mec A and erm genes in coagulase-negative staphylococci isolated from platelet concentrates bags

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