The Emergence of new-onset SLE following SARS-CoV-2 vaccination

Nune, Arvind; Iyengar, Karthikeyan P; Ish, Pranav; Varupula, Bhanu; Musat, Cristina Aimee; Sapkota, Hem

doi:10.1093/qjmed/hcab229

Cited by 29 publications

(21 citation statements)

References 5 publications

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“…An overactive immune response after mRNA COVID-19 vaccination may be related to the onset of Evans syndrome associated with SLE. New-onset SLE after COVID-19 vaccination has already been reported [ 17 ]. However, another study showed that autoimmune disease flare occurred in only one patient in 280 patients [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

New-onset Evans syndrome associated with systemic lupus erythematosus after BNT162b2 mRNA COVID-19 vaccination

et al. 2021

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Evans syndrome presents as concurrent autoimmune hemolytic anemia (AIHA) and immune thrombocytopenia (ITP). Systemic lupus erythematosus (SLE) is the most frequent autoimmune disorder associated with Evans syndrome. We herein report a case of new-onset Evans syndrome associated with SLE after BNT162b2 mRNA coronavirus disease 2019 (COVID-19) vaccination in a 53-year-old woman. Blood examination at diagnosis showed hemolytic anemia with a positive Coombs test and thrombocytopenia. Hypocomplementemia and the presence of lupus anticoagulant indicated a strong association with SLE. Prednisolone administration rapidly restored hemoglobin level and platelet count. This case suggests that mRNA COVID-19 vaccination may cause an autoimmune disorder. Physicians should be aware of this adverse reaction by mRNA COVID-19 vaccination and should consider the benefits and risks of vaccination for each recipient.

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Section: Discussionmentioning

confidence: 99%

New-onset Evans syndrome associated with systemic lupus erythematosus after BNT162b2 mRNA COVID-19 vaccination

et al. 2021

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“…There are 302 preliminary reports of GBS following the J&J vaccine after more than 18 million vaccine doses were administered [ 2 , 3 ]. There is limited data on the emergence of systemic lupus erythematosus (SLE) with the COVID-19 vaccine [ 4 ]. In this case report, we have presented a patient with a history of well-controlled Sjogren’s syndrome diagnosed with systemic lupus erythematosus after receiving the second dose of the COVID-19 vaccine.…”

Section: Introductionmentioning

confidence: 99%

COVID-19 Vaccination as a Potential Trigger for New-Onset Systemic Lupus Erythematosus

Kaur¹,

Zafar²,

Capitle³

et al. 2022

Cureus

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Immune hyperactivation has been linked to various vaccines. We present a potential association of newonset systemic lupus erythematosus (SLE) post-COVID-19 immunization. The patient is a 54-year-old male admitted for evaluation of flu-like symptoms two weeks after receiving the second dose of the COVID-19 vaccine. Physical examination revealed high-grade fever, diffuse bilateral non-tender cervical lymphadenopathy, and erythematous maculopapular palpable purpuric lesions on bilateral feet. Laboratory evaluation showed a significant hypocomplementemia (C3 < 11 mg/dL, C4 < 3 mg/dL, and CH50 < 10 U/mL), high titer antinuclear antibody, anti-dsDNA antibodies, anti-Sjogren's syndrome-related antigen A antibodies, anti-Sjogren's syndrome-related antigen B antibodies, anti-Smith antibodies, antiribonucleoprotein antibodies, anti-histone antibodies with a negative malignancy, and infection workup. The patient was treated with a high dose of steroids with a positive response. This case highlights the possibility of SLE, a rare adverse event following COVID-19 vaccination.

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“…However, our search found three other possible cases of COVID-19-induced SLE (Table 2). New development of SLE with musculoskeletal features and lymphadenitis after a COVID-19 vaccine was reported by Nune et al in one Caucasian man who was diagnosed based on the presence of polyarthritis, oral ulcers, leukopenia, lymphopenia, strongly positive ANA and anti-dsDNA results, and low complement C4 and C3 levels [8]. The other case reported by Patil and Patil also shares the same clinical manifestation despite a different type of received vaccine [9].…”

Section: Discussionmentioning

confidence: 72%

“…Another observational study that examines the side effect and flares risk after Pfizer-BioNTech mRNA COVID-19 vaccination showed mild side effects of vaccination and minimal risk for flare [7]. To date, new SLE cases after COVID-19 vaccines have occurred in three patients [8][9][10]. Herein, we describe another unique and rare presentation of a newly developed SLE case following the Pfizer-BioNTech COVID-19 vaccine.…”

Section: Introductionmentioning

confidence: 84%

Systemic lupus erythematosus with acute pancreatitis and vasculitic rash following COVID-19 vaccine: a case report and literature review

et al. 2022

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) is a global pandemic that is caused by COVID-19 virus, which was initially identified in December 2019 in Wuhan, China. Vaccination is one of the most effective public health interventions, and soon after the Pfizer/BioNTech (BNT162b2) vaccine became available late in 2020, it began to be actively used to fight against COVID-19. Since then, cases of vaccine-associated immune-mediated diseases (IMDs) have been reported. There have been few cases of IMD flare-ups or onset after COVID-19 vaccine administration, and emerging IMDs may be identified over next few years after high use of this vaccine. To this day, few cases of newly diagnosed systemic lupus erythematosus (SLE) following COVID-19 vaccine exposure were reported. Herein, we present the case of a patient diagnosed with SLE, acute pancreatitis, and vasculitic skin rash on the extremities 1 week after the first dose of the Pfizer-BioNTech COVID-19 vaccine. Key Point• COVID-19 Vaccine induced Systemic Lupus Erythematosus.

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The Emergence of new-onset SLE following SARS-CoV-2 vaccination

Cited by 29 publications

References 5 publications

New-onset Evans syndrome associated with systemic lupus erythematosus after BNT162b2 mRNA COVID-19 vaccination

New-onset Evans syndrome associated with systemic lupus erythematosus after BNT162b2 mRNA COVID-19 vaccination

COVID-19 Vaccination as a Potential Trigger for New-Onset Systemic Lupus Erythematosus

Systemic lupus erythematosus with acute pancreatitis and vasculitic rash following COVID-19 vaccine: a case report and literature review

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