The Emergence of Novel Langya Henipavirus in China

Chen, Rosalie; Quigley, Ashley

doi:10.31646/gbio.176

Cited by 3 publications

(18 citation statements)

References 23 publications

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“…1,3,4 Furthermore, it has been detected with low positivity rates in rodent species such as Myodes rutilus, Apodemus agrarius, and Mus musculus. 5 The viral genome is of particular interest due to its nonsegmented, negative strand RNA composition. 1 With a length of 18,402 nucleotides, it stands notably longer by around 2700 bases compared to other Paramyxoviruses.…”

Section: Host Structure and Life Cyclementioning

confidence: 99%

“…3,5,15,22 In addition, severe cases may result in thrombocytopaenia, which may cause melaena, gingival bleeding, and abdominal discomfort. 3,5,15,22,24,25 In severe cases, patients may experience abnormal neurological symptoms or dysfunctions of the liver and kidney. 5,16,24 Serious complications associated with LayV can cause long-lasting harm to the health of patients.…”

Section: Clinical Aspects and Human-to-human Transmissibilitymentioning

confidence: 99%

“…The spectrum of clinical manifestations ranges from mild to severe symptoms. Patients can manifest with fever, cough, expectoration, headache, myalgia, nausea, vomiting, fatigue, poor appetite, and lymphadenopathy 3,5,15,22 . In addition, severe cases may result in thrombocytopaenia, which may cause melaena, gingival bleeding, and abdominal discomfort 3,5,15,22,24,25 .…”

Section: Clinical Aspects and Human‐to‐human Transmissibilitymentioning

confidence: 99%

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A comprehensive review of Langya virus and framework for future zoonotic disease control

Thien,

Tran,

Uyen

et al. 2024

Reviews in Medical Virology

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First reported in August 2022, the Langya virus (LayV) has emerged as a potential global health threat in the post‐COVID‐19 era. Preliminary reports show that 35 patients near Shandong and Henan, China experienced a febrile acute LayV infection. We conducted this review following the PRISMA protocol to synthesise current knowledge on LayV's characteristics in terms of molecular, clinical, and public health perspectives. This virus belongs to the Paramyxoviridae family and carries a non‐segmented, single‐stranded negative‐sense RNA genome. Shrews may be the natural reservoir of the virus. Clinical symptoms range from mild flu‐like symptoms to severe manifestations involving pneumonia, haematological disorders, and organ dysfunction. Diagnostic methods include PCR and ELISA assays. Despite the absence of established treatments, antiviral drugs such as ribavirin and chloroquine may be useful in some cases. In light of prevention, a comprehensive approach that emphasises multidisciplinary collaboration is crucial for early surveillance and response. Urgent global efforts are needed for vaccine development and preparedness against this potential pandemic threat. As the viral dynamics remain uncertain, a proactive approach is vital to mitigate the impact of not only LayV but also future threats on a large scale in long term.

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Section: Host Structure and Life Cyclementioning

confidence: 99%

Section: Clinical Aspects and Human-to-human Transmissibilitymentioning

confidence: 99%

Section: Clinical Aspects and Human‐to‐human Transmissibilitymentioning

confidence: 99%

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A comprehensive review of Langya virus and framework for future zoonotic disease control

Thien,

Tran,

Uyen

et al. 2024

Reviews in Medical Virology

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“…Disease surveillance revealed no shared exposure sources or close contact between infected individuals, indicating that human infection may have happened sporadically, according to the research teams 17 . There is currently no evidence that the virus may transfer from human to human 18 . The discovery of a novel virus in dozens of individuals in eastern China may not be the start of the next pandemic, but it does highlight how readily viruses may spread undetected from animals to people, according to scientists 19 .…”

Section: Recommendationsmentioning

confidence: 99%

“…The two provinces where the virus was discovered, as well as other parts of China, should perform additional research screening for Langya henipavirus (Fig. 2 ) 18 . Critical questions need to be addressed regarding how prevalent the new virus may be in nature, how it is affecting people, and how threatening it is to public health.…”

Section: Recommendationsmentioning

confidence: 99%

Is the New Langya virus in China a threat to global health? A short communication

Uwishema

Shariff

Rai

et al. 2023

Annals of Medicine &Amp; Surgery

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The recently detected virus in eastern China in 2018 led to some health concerns, especially with the global trend of spreading viruses. As a new RNA-detected genus of the henipavirus family was found in Eastern China, the number of patients affected has reached 35 through zoonotic spread, with symptoms ranging from simple fever to fatal affection of vital organs such as the brain, liver, and kidneys. Researchers have found that shrew animals might be a potential reservoir for the Langya virus; however, data is still limited regarding human-to-human transmission. Current efforts by the Chinese Health Ministry and the Taiwan Centers for Disease Control and Prevention to deduct the spread of the virus and track its origin by trying to sequence the disease genome are evident. With all this in mind, the recommendation to face this new novel virus revolves around protecting the most vulnerable population at risk of being infected, such as farmers, and preventing the spread of the virus. Efforts must be directed toward screening animals for henipavirus and diving more deeply into the etiology of how this virus has spread to humans to help understand the spread of zoonotic viruses in the future.

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Recent updates on langya virus

Gangwar,

Kumar,

Zargar

et al. 2023

Pharmaspire

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In this review, we discussed about the recent outbreak of langya virus (layV). After the major viral outbreak of Covid-19, a newly identified layV was first identified in northeastern provinces of Shandong and Henan in 2018, it, also known as langya henipavirus, belongs to the Paramyxoviridae virus family of single-stranded ribonucleic acid (RNA) viruses that cause different types of viral infections. From 2018 to 2022, a total of 35 reported incidents were either farmers or workers in factories and it was potentially the pathogens in 26 patients. Transmission of the virus is likely to occur from animals to humans. The presence of the virus and its RNA was identified mostly in shrews, indicating that shrews are the virus’s natural reservoir. The information was gathered from Google Scholar, PubMed, ResearchGate, World Health Organization (WHO) website, and other web pages from October 2022 to January 2023. The main aim of this study is to provide current information and awareness about layV to society, health-care professionals, researchers, and academicians on this disease, etc. If people are aware of this disease, then they can handle and prevent themselves. For the prevention for this disease, we include all the relevant information about layV symptoms, prevention, etiology, transmission, epidemiology, and treatment according to the WHO. This paper is helpful for future point of view because if on one takes it seriously then may be in the future, it will become a severe outbreak like Covid-19. In a world where outbreaks like COVID-19 and monkeypox occur, we must keep an eye out for developing infectious diseases like layV.

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The Emergence of Novel Langya Henipavirus in China

Cited by 3 publications

References 23 publications

A comprehensive review of Langya virus and framework for future zoonotic disease control

A comprehensive review of Langya virus and framework for future zoonotic disease control

Is the New Langya virus in China a threat to global health? A short communication

Recent updates on langya virus

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