Diagnostic errors in health care pose significant risks to patient safety and are disturbingly common. In the emergency department (ED), the chaotic and high‐pressure environment increases the likelihood of these errors, as emergency clinicians must make rapid decisions with limited information, often under cognitive overload. Artificial intelligence (AI) offers promising solutions to improve diagnostic errors in three key areas: information gathering, clinical decision support (CDS), and feedback through quality improvement. AI can streamline the information‐gathering process by automating data retrieval, reducing cognitive load, and providing clinicians with essential patient details quickly. AI‐driven CDS systems enhance diagnostic decision making by offering real‐time insights, reducing cognitive biases, and prioritizing differential diagnoses. Furthermore, AI‐powered feedback loops can facilitate continuous learning and refinement of diagnostic processes by providing targeted education and outcome feedback to clinicians. By integrating AI into these areas, the potential for reducing diagnostic errors and improving patient safety in the ED is substantial. However, successfully implementing AI in the ED is challenging and complex. Developing, validating, and implementing AI as a safe, human‐centered ED tool requires thoughtful design and meticulous attention to ethical and practical considerations. Clinicians and patients must be integrated as key stakeholders across these processes. Ultimately, AI should be seen as a tool that assists clinicians by supporting better, faster decisions and thus enhances patient outcomes.