The Emerging Cell Biology of Thyroid Stem Cells

Davies, Terry F.; Latif, Rauf; Minsky, Noga; Ma, Risheng

doi:10.1210/jc.2011-1047

Cited by 46 publications

(23 citation statements)

References 107 publications

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“…One possible reason for the development of these resistant tumours could be due to the presence of cells that have the capability to self-divide, metastasize and resist chemotherapeutic interventions. These properties mimic closely those of stem cells (11,12).…”

Section: Introductionsupporting

confidence: 62%

Thyroid Stem Cells: Concept and Clinical Implications

Latar

Mahkamova²,

Aspinall³

et al. 2016

JSA

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Thyroid pathology is the commonest endocrine surgical problem encountered. However, the study of thyroid stem cells is relatively new in the field of stem cell research. Since the identification of thyroid stem cells in 1992, research interest in this area has been increasing mainly based on furthering our knowledge of the biology of these important cells that are thought to be responsible for tumourigenesis and propagation of cancers. This article reviews the current science and biology of thyroid stem cells and summarizes their potential role in the general management of thyroid disorders.

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Section: Introductionsupporting

confidence: 62%

Thyroid Stem Cells: Concept and Clinical Implications

Latar

Mahkamova²,

Aspinall³

et al. 2016

JSA

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“…Printed in Great Britain been proposed (Davies et al 2011, Derwahl 2011. Stem cells are undifferentiated cells that possess the capacity of self-renewal and the generation of more differentiated progenitor cells (Davies et al 2011).…”

Section: Endocrine-related Cancermentioning

confidence: 99%

“…Stem cells are undifferentiated cells that possess the capacity of self-renewal and the generation of more differentiated progenitor cells (Davies et al 2011). These cells that reside in any organ and tissue for the lifetime of the organism have been detected in the human thyroid gland and in goiters and cancer stem cells in thyroid cancer cell lines and thyroid cancer tissues (Thomas et al 2006, Lan et al 2007, Mitsutake et al 2007, Fierabracci et al 2008, Todaro et al 2010, Zheng et al 2010, Malaguarnera et al 2011.…”

Section: Endocrine-related Cancermentioning

confidence: 99%

Estrogen and its role in thyroid cancer

Derwahl¹,

Nicula²

2014

Endocrine Related Cancer

240

166

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Proliferative thyroid diseases are more prevalent in females than in males. Upon the onset of puberty, the incidence of thyroid cancer increases in females only and declines again after menopause. Estrogen is a potent growth factor both for benign and malignant thyroid cells that may explain the sex difference in the prevalence of thyroid nodules and thyroid cancer. It exerts its growth-promoting effect through a classical genomic and a non-genomic pathway, mediated via a membrane-bound estrogen receptor. This receptor is linked to the tyrosine kinase signaling pathways MAPK and PI3K. In papillary thyroid carcinomas, these pathways may be activated either by a chromosomal rearrangement of the tyrosine receptor kinase TRKA, by RET/PTC genes, or by a BRAF mutation and, in addition, in females they may be stimulated by high levels of estrogen. Furthermore, estrogen is involved in the regulation of angiogenesis and metastasis that are critical for the outcome of thyroid cancer. In contrast to other carcinomas, however, detailed knowledge on this regulation is still missing for thyroid cancer.

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“…33 While, FGF and bone morphogenetic protein (BMP) signalling pathways act in the early stages of thyroid development 34 before TSH/TSH-R and IGF/insulin signalling that promote the full differentiation of follicular cells ( Figure 4 and Table 1). 35 In order to identify early and late markers of thyroid development, several studies are being carried out using mouse ESCs as a source of in vitro differentiating thyrocytes. Lin et al 36 demonstrated that mouse ESCs formed embryoid bodies that upon differentiation, express a set of thyroid-specific markers, such as Pax-8, thyroid peroxidase (TPO), Tg, sodium/iodide cotransporter (NIS) and TSH-R.…”

Section: Normal Thyroid Stem Cellsmentioning

confidence: 99%

Normal vs cancer thyroid stem cells: the road to transformation

et al. 2015

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Recent investigations in thyroid carcinogenesis have led to the isolation and characterisation of a subpopulation of stem-like cells, responsible for tumour initiation, progression and metastasis. Nevertheless, the cellular origin of thyroid cancer stem cells (SCs) remains unknown and it is still necessary to define the process and the target population that sustain malignant transformation of tissue-resident SCs or the reprogramming of a more differentiated cell. Here, we will critically discuss new insights into thyroid SCs as a potential source of cancer formation in light of the available information on the oncogenic role of genetic modifications that occur during thyroid cancer development. Understanding the fine mechanisms that regulate tumour transformation may provide new ground for clinical intervention in terms of prevention, diagnosis and therapy.Oncogene advance online publication, 11 May 2015; doi:10.1038/onc.2015.138

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The Emerging Cell Biology of Thyroid Stem Cells

Abstract: Advances in thyroid stem cell biology are providing not only insight into thyroid development but may offer therapeutic potential in thyroid cancer and future thyroid cell replacement therapy.

Cited by 46 publications

References 107 publications

Thyroid Stem Cells: Concept and Clinical Implications

Thyroid Stem Cells: Concept and Clinical Implications

Estrogen and its role in thyroid cancer

Normal vs cancer thyroid stem cells: the road to transformation

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