The emerging development of tumor mutational burden in patients with NSCLC

Zhang, Y; Wang, Lifeng; Li, Rutian; Liu, Baorui

doi:10.2217/fon-2019-0650

Cited by 10 publications

(3 citation statements)

References 112 publications

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“…TMB is generally defined as the total number of somatic coding mutations, which is associated with the generation of neoantigens that induce antitumour immunity[ 17 ]. Higher TMB scores are generally associated with durable clinical benefit and improved objective response in tumour immunotherapy, and it can predict immunotherapy efficacy in multiple tumours including NSCLC[ 18 , 19 ]. We calculated the tumour mutation burden of LUAD patients and the result showed the top 15 genes with the highest mutation frequency ( Figure 9(A, B) ).…”

Section: Resultsmentioning

confidence: 99%

Identification of endoplasmic reticulum stress-related lncRNAs in lung adenocarcinoma by bioinformatics and experimental validation

Xin,

Sun,

Meng

et al. 2023

Annals of Medicine

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Background Endoplasmic reticulum stress (ERs) is an important cellular self-defence mechanism, which is closely related to tumorigenesis and development. However, the role of endoplasmic reticulum stress state in the development of lung adenocarcinoma (LUAD) has not been clarified. Methods The lncRNAs associated with endoplasmic reticulum stress were identified by co-expression analysis in public databases, and by the least absolute shrinkage and selection operator (LASSO) regression and multivariate Cox regression modelling, we constructed a prognostic model based on endoplasmic reticulum stress-related lncRNAs (ERs-related lncRNAs), performed immune analysis, TME, TMB and clinical drug prediction for model-related risk scores, and performed correlation validation in public databases and at the human tissue level. Results Five ERs-related lncRNAs were used to construct an ERs-related lncRNA signature (ERs-related LncSig), which can predict the prognosis of LUAD. Patients in the high-risk group had worse survival, and differences existed in immune cell infiltration, immune function, immune checkpoint analysis, tumour microenvironment (TME), tumour mutational burden (TMB), immunotherapy efficacy, and sensitivity to some commonly used chemotherapeutic agents between high and low risk groups. Conclusion Our study demonstrated that ERs-related lncRNA signature can be used for the prognostic evaluation of LUAD patients and may provide new insights into clinical decision-making and personalised medicine for LUAD.

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Section: Resultsmentioning

confidence: 99%

Identification of endoplasmic reticulum stress-related lncRNAs in lung adenocarcinoma by bioinformatics and experimental validation

Xin,

Sun,

Meng

et al. 2023

Annals of Medicine

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“…Patients with advanced tumors who cannot receive standard treatment may benefit from immunotherapy if they have a high TMB. However, TMB is not unanimously accepted ( 33 , 34 ). The CheckMate 227 study updates OS data and finds that TMB does not predict OS gain.…”

Section: Discussionmentioning

confidence: 99%

Advanced gallbladder cancer with high tumor mutation burden: a case report and literature review

Wang,

Liu,

Yan

et al. 2024

AME Case Rep

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Background Gallbladder cancer (GBC) is a common malignant tumor of the biliary system. It is characterised by insidious onset, rapid progression and poor prognosis. Symptoms often indicate advanced or late-stage disease, with a 5-year survival rate of only 5–15%. Case Description We present a case study of a patient with GBC who had a tumor mutation burden (TMB) of 32.5/MB (≥10 muts/MB). The patient received mFOLFIRINOX as first-line chemotherapy, which demonstrated significant efficacy. After stabilizing the disease, a sequential chemotherapy regimen was chosen. This regimen combined the immune checkpoint inhibitor (ICI) toripalimab (JS001), a humanised IgG4 monoclonal antibody targeting programmed cell death protein 1 (PD-1), with S-1 therapy, an oral fluoropyrimidine derivative. However, this treatment did not provide any significant clinical benefit for the patient. Therefore, we hypothesise that combining immunotherapy with chemotherapy may be more effective as a first line treatment for high-TMB advanced GBC. This hypothesis needs to be validated in large-scale clinical studies. Conclusions In summary, mFOLFIRINOX is a safe and effective first-line chemotherapy regimen for advanced GBC. The timing of combining immunotherapy with chemotherapy requires careful consideration. Further clinical trials involving immunotherapy in advanced GBC are necessary to identify biomarkers that can guide clinical decisions.

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“…Porém, problemas pré-analíticos, analíticos e pós-analíticos foram investigados, resultando em pouca sensibilidade e especificidade robusta do PD-L1 IHQ, devendo haver cautela antes da sua implementação. O biomarcador tumor mutacional burden/tumor mutation burden (TMB) é um potencial promissor em PD-1 monoterapia, tendo sido observada uma correlação de TMB alto e resposta clínica a ICIs em ensaios (URUGA; MINO-KENUDSON, 2021;ZHANG et al, 2020).…”

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Desafios para a Atenção Primária à Saúde no Brasil durante a pandemia de COVID-19

Fonseca¹,

Borges²,

Ribeiro³

et al. 2022

O Cenário Pós-Pandêmico No Brasil E No Mundo: Lições Aprendidas E Reflexões Sobre a Saúde Pública E a Importância Da Adoção De

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Teelessaúde e Atenção Primária à Saúde na p .... OBJETIVO: Descrever a importância da implementação da educação em saúde na prevenção de neoplasias penianas. MÉTODOS: Trata-se de uma revisão narrativa da literatura, realizada entre os meses de junho e julho de 2022, através dos bancos de dados da Biblioteca Virtual em Saúde. Utilizados os Descritores em Ciências da Saúde (DeCS) em cruzamento com o operador booleano AND. Estabelecidos os critérios de inclusão e exclusão, desta forma, foram selecionados cinco artigos para compor o estudo. RESULTADOS: Os principais resultados evidenciam a diminuição da incidência da neoplasia peniana conforme a implementação de ações educacionais, desta forma constata-se que a educação em saúde é uma ferramenta essencial na promoção da saúde do homem, em relação a saúde sexual na prevenção de neoplasias, e o profissional da enfermagem destaca-se neste processo. Em relação ao perfil social dos pacientes acometidos pela neoplasia destaca-se a baixa escolaridade, evidenciando na importância da assistência adequada e compreensível para todos os níveis sociais. CONCLUSÃO: A educação é um instrumento imprescindível na promoção da saúde, e desta forma faz-se necessário a formulação de protocolos assistenciais, além da inclusão de componentes relacionados à saúde homem, na formação acadêmica do profissional. PALAVRAS-CHAVE: Neoplasias penianas. Educação em saúde. Saúde do homem. OBJECTIVE:To describe the importance of implementing health education in the prevention of penile neoplasms. METHODS: This is a narrative review of the literature, carried out between June and July 2022, through the Virtual Health Library databases. Descriptors in Health Sciences (DeCS) were used in crossing with the Boolean operator AND. Having established the inclusion and exclusion criteria, in this way, five articles were selected to compose the study. RESULTS: The main results show the decrease in the incidence of penile neoplasia, in relation to the social profile of patients affected by the neoplasia, identified: Married, white, heterosexual, average age -above 40 to 65 years, low education and retirees; Health education proves to be an essential tool in the promotion of men's health, in relation to sexual health in the prevention of neoplasms, and the nursing professional stands out in this process. CONCLUSION: Education is an essential tool in health promotion, and thus, it is necessary to formulate care protocols, in addition to the inclusion of components related to men's health, in the professional's academic training.

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The emerging development of tumor mutational burden in patients with NSCLC

Cited by 10 publications

References 112 publications

Identification of endoplasmic reticulum stress-related lncRNAs in lung adenocarcinoma by bioinformatics and experimental validation

Identification of endoplasmic reticulum stress-related lncRNAs in lung adenocarcinoma by bioinformatics and experimental validation

Advanced gallbladder cancer with high tumor mutation burden: a case report and literature review

Desafios para a Atenção Primária à Saúde no Brasil durante a pandemia de COVID-19

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