The emerging principles for acne biogenesis: A dermatological problem of puberty

Qidwai, Afifa; Pandey, Manisha; Pathak, Sarvesh; Kumar, Rajesh; Dikshit, Anupam

doi:10.1016/j.humic.2017.05.001

Cited by 19 publications

(33 citation statements)

References 45 publications

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“…16,25,26 In acne-prone and acne-affected skin, it has, therefore, become crucial to maintaining the balance of the cutaneous microbiome within its follicles and on the surface of the skin. 16,25,26 Testosterone and dihydrotestosterone (DHT) are more selective to sebocytes of the face and are crucial for regulating sebum production. 26 External factors that contribute to acne include cosmetics, stress, tobacco, or exposure to ultraviolet.…”

Section: Backg Rou N Dmentioning

confidence: 99%

Nonprescription acne vulgaris treatments: Their role in our treatment armamentarium—An international panel discussion

Dréno

Araviiskaia

Kérob

et al. 2020

J of Cosmetic Dermatology

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Background Acne vulgaris (acne), a common inflammatory skin disorder, has its peak incidence between 14 and 19 years of age, with girls frequently developing acne earlier than boys. Over recent years, persistent acne is becoming more prevalent in adult women. Objectives This review and panel discussion addresses challenges in acne management, particularly in adult women. The role which nonprescription acne treatment can play is explored when used as monotherapy or as an adjunctive treatment for acne of all severity. Methods The best available evidence on nonprescription acne treatment was coupled with the opinion of an international expert panel of dermatologists to adopt statements and recommendations discussed in this review. Results All severity of acne has a significant burden on patients. Addressing environmental factors that are important for the individual with acne may help to educate, prevent, effectively manage, and maintain acne, as per the panel. They agreed that the adult female acne population has unique needs because of their aging skin and social environment. Nonprescription acne treatment products may help to balance the efficacy and tolerability of prescription acne treatment. Currently, there are no specific guidelines for how to use nonprescription acne treatment products in these patients. Conclusion The panel agreed that guidelines including nonprescription acne treatment either as monotherapy for mild acne or in combination with prescription treatments for more severe acne would address a significant unmet need.

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Section: Backg Rou N Dmentioning

confidence: 99%

Nonprescription acne vulgaris treatments: Their role in our treatment armamentarium—An international panel discussion

Dréno

Araviiskaia

Kérob

et al. 2020

J of Cosmetic Dermatology

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“…Changes in the hair follicle and the sebaceous gland, collectively referred to as the pilosebaceous unit, are implicated in acne onset . Acne lesions are thought to arise as a result of excess sebum production, pore hyperkeratinization and abnormal growth of lipophilic anaerobic bacteria such as Cutibacterium acnes (formerly referred to as Propionibacterium acnes ), resulting in overcolonization and follicle blockage, and subsequent inflammation . There remains significant confusion and controversy regarding the name of this ubiquitous and historic organism, so throughout this review we will refer to it using the new name, C. acnes .…”

Section: Acne Vulgarismentioning

confidence: 99%

“…4 Acne lesions are thought to arise as a result of excess sebum production, pore hyperkeratinization and abnormal growth of lipophilic anaerobic bacteria such as Cutibacterium acnes (formerly referred to as Propionibacterium acnes), resulting in overcolonization and follicle blockage, and subsequent inflammation. [5][6][7] There remains significant confusion and controversy regarding the name of this ubiquitous and historic organism, so throughout this review we will refer to it using the new name, C. acnes. Acne development stages are not known to be sequential and it is not clear which stage precedes which, or how these stages are interconnected.…”

Section: Acne Vulgarismentioning

confidence: 99%

The role of the skin microbiota in acne pathophysiology

et al. 2019

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Summary Background The role of skin microbiota in acne remains to be fully elucidated. Initial culture‐based investigations were hampered by growth rate and selective media bias. Even with less biased genomic methods, sampling, lysis and methodology, the task of describing acne pathophysiology remains challenging. Acne occurs in sites dominated by Cutibacterium acnes (formerly Propionibacterium acnes) and Malassezia species, both of which can function either as commensal or pathogen. Objectives This article aims to review the current state of the art of the microbiome and acne. Methods The literature regarding the microbiome and acne was reviewed. Results It remains unclear whether there is a quantitative difference in microbial community distribution, making it challenging to understand any community shift from commensal to pathogenic nature. It is plausible that acne involves (i) change in the distribution of species/strains, (ii) stable distribution with pathogenic alteration in response to internal (intermicrobe) or external stimuli (host physiology or environmental) or (iii) a combination of these factors. Conclusions Understanding physiological changes in bacterial species and strains will be required to define their specific roles, and identify any potential intervention points, in acne pathogenesis and treatment. It will also be necessary to determine whether any fungal species are involved, and establish whether they play a significant role. Further investigation using robust, modern analytic tools in longitudinal studies with a large number of participants, may make it possible to determine whether the microbiota plays a causal role, is primarily involved in exacerbation, or is merely a bystander. It is likely that the final outcome will show that acne is the result of complex microbe–microbe and community–host interplay.

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“…Acne is a chronic disease of the pilosebaceous unit, which characterized by non-inflammatory lesions of open/closed comedones, and inflammatory lesions of papules, pustules nodules, and cysts of human beings (Lynn et al 2016;Qidwai et al 2017;Kumar et al 2016;Pochi 1990). Acne vulgaris is the most common inflammatory skin disease that affects over 80% of adolescents (Lynn et al 2016;Qidwai et al 2017). Although acne is not life-threatening, it causes physical, psychological, and social impacts by an exhibition of diverse lesions on the face, chest, shoulders, and back (Kumar et al 2016).…”

Section: Introductionmentioning

confidence: 99%

Toll-like receptor 2 plays a critical role in pathogenesis of acne vulgaris

Zhang

Choi²,

Lee

et al. 2019

biomed dermatol

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Background: Acne vulgaris is a common inflammatory skin disease, affecting adolescents across the globe. Recent evidences underline that Propionibacterium acnes (P. acnes) promotes acne through Toll-like receptor (TLR) activation. Especially, Toll-like receptor 2 (TLR2) has emerged as one of the major classes of pattern recognition receptors (PRRs) that are recognizing P. acnes in the epidermis and responsible for inflammation. Conclusions: Although P. acnes has been known to be one of the major causes of acne vulgaris, an appropriate drug to alleviate acne pathogenesis is poorly developed. This review focuses on the molecular structure of TLR2 as well as mechanism how TLR2 recognize P. acnes to induce inflammatory cytokines, which is related to acne vulgaris pathogenesis. Rigorous study about P. acnes mediated by TLR2 activation may provide insight into novel therapeutic targets of acne vulgaris.

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The emerging principles for acne biogenesis: A dermatological problem of puberty

Cited by 19 publications

References 45 publications

Nonprescription acne vulgaris treatments: Their role in our treatment armamentarium—An international panel discussion

Nonprescription acne vulgaris treatments: Their role in our treatment armamentarium—An international panel discussion

The role of the skin microbiota in acne pathophysiology

Toll-like receptor 2 plays a critical role in pathogenesis of acne vulgaris

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