The Emerging Role of Circular RNAs in Cerebral Vascular Disorders

Liu, Wei; Gao, Yan

doi:10.1159/000515807

Cited by 3 publications

(2 citation statements)

References 42 publications

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“…Noncoding, circular RNAs (circRNAs) are ubiquitous in neural tissue and differentially expressed in stroke patients with subtype-specific profiles [ 78 , 178 , 208 ]. One group was able to predict IS outcomes by measuring only three circRNAs, thus demonstrating robust biomarker potential [ 333 ].…”

Section: Inflammationmentioning

confidence: 99%

Genetics of ischemic stroke functional outcome

Carnwath,

Demel,

Prestigiacomo

2024

J Neurol

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Ischemic stroke, which accounts for 87% of cerebrovascular accidents, is responsible for massive global burden both in terms of economic cost and personal hardship. Many stroke survivors face long-term disability—a phenotype associated with an increasing number of genetic variants. While clinical variables such as stroke severity greatly impact recovery, genetic polymorphisms linked to functional outcome may offer physicians a unique opportunity to deliver personalized care based on their patient’s genetic makeup, leading to improved outcomes. A comprehensive catalogue of the variants at play is required for such an approach. In this review, we compile and describe the polymorphisms associated with outcome scores such as modified Rankin Scale and Barthel Index. Our search identified 74 known genetic polymorphisms spread across 48 features associated with various poststroke disability metrics. The known variants span diverse biological systems and are related to inflammation, vascular homeostasis, growth factors, metabolism, the p53 regulatory pathway, and mitochondrial variation. Understanding how these variants influence functional outcome may be helpful in maximizing poststroke recovery.

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Section: Inflammationmentioning

confidence: 99%

Genetics of ischemic stroke functional outcome

Carnwath,

Demel,

Prestigiacomo

2024

J Neurol

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“…CircRNAs were found to serve a critical role in embryonic development, and the dysfunctions of circRNAs were associated with different developmental disorders. 10,11 For example, circRNAs involved in the development of many diseases, such as embryonic heart, 12 neurological disorders 13,14 and male infertility. 15,16 However, the roles of circRNAs in cleft palates by TCDD induce were still unknown.…”

Section: Introductionmentioning

confidence: 99%

Identification and characterization of differentially expressed circRNA in 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced cleft palate

et al. 2023

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Various circular RNAs (circRNAs) are novel class of non-coding RNAs, which are pervasively transcribed in the genome. CircRNAs play important roles in human, animals and plants. Up to now, there was no report regarding circRNAs of cleft palate by 2,3,7,8-tetrachlorodibenzo-pdioxin (TCDD) induce. The present study screened identification and characterization of differential expressed-circRNAs in TCDD-induced cleft palate. 6903 circRNAs candidates came from cleft palates. Among them, 3525 circRNAs are up-regulation, and 3378 circRNAs are down-regulation by TCDD induce. The cluster and GO analysis found that circRNAs involved in biological process, cellular component, and molecular function. Through the analysis of KEGG Pathway, circRNAs made functions via classical signaling pathway in cleft palate, such as TGF-beta signaling pathway, BMP signal pathway, MAPK signaling pathway. In addition, we found down-regulated circRNA224, circRNA3302 and up-regulated circRNA5021 targeted tgfbr3, but up-regulated circRNA4451 targeted tgfbr2. circRNA4451 may make functions through TGF-beta signaling pathway. These results suggested that many different circRNAs may make important role in TCDD-induced cleft palate, which provided a theoretical basis for further research.

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