2018
DOI: 10.1002/jcp.27068
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The emerging role of extracellular Ca2+ in osteo/odontogenic differentiation and the involvement of intracellular Ca2+ signaling: From osteoblastic cells to dental pulp cells and odontoblasts

Abstract: Calcium ions (Ca ) is the main element of dental pulp capping materials. Ca signaling plays a crucial role in a myriad of cell activities. An overwhelming array of studies have already reported the experimental and clinical benefits of Ca -enriched materials in the treatment of teeth with accidental vital pulp exposure and incomplete root formation. Thus, Ca signaling has always been an excellent target for the design of various novel biomaterials for use in revitalizing or regenerative endodontic procedures. … Show more

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Cited by 29 publications
(16 citation statements)
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References 254 publications
(561 reference statements)
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“…He regarded odontoblasts as a special kind of osteoblasts. It is indeed remarkable how similar both cells are functionally (An, 2018). Even today, very often no distinction is made between both cell types and reference is simply made to "osteo/odontogenic differentiation" (e.g., Lin et al, 2019).…”
Section: Discussionmentioning
confidence: 99%
“…He regarded odontoblasts as a special kind of osteoblasts. It is indeed remarkable how similar both cells are functionally (An, 2018). Even today, very often no distinction is made between both cell types and reference is simply made to "osteo/odontogenic differentiation" (e.g., Lin et al, 2019).…”
Section: Discussionmentioning
confidence: 99%
“…Cellular Ca 2+ homeostasis is maintained through the integrated and coordinated function of Ca 2+ transport molecules, Ca 2+ buffers and sensors (Krebs et al 2015). Cellular Ca 2+ uptake and extrusion are mediated by a variety of channels located in the plasma membrane, which results in changes in the free Ca 2+ concentration (An 2019). Calcium ions may be partially released from CMET, where they are then absorbed into cells through Ca 2+ Figure The persistence of each material on cell mineralization was measured after few weeks of storage.…”
Section: Discussionmentioning
confidence: 99%
“…At the cellular level, calcium acts as a ubiquitous second messenger with multiple physiological roles on intracellular mechanisms such as proliferation and cell differentiation by activating protein kinases. This explains the fact that calcium ion release from pulp capping materials is investigated in vitro for their potential in inducing odontoblastic differentiation and mineralization [1]. However, studies evaluating the calcium concentration released from the materials are never directly related to the pulp effects of these concentrations and the link between these events remains speculative.…”
Section: Dear Editormentioning
confidence: 99%