The Emerging Role of Fusarium Infections in Patients with Cancer

Anaissie, Elias; Kantarjian, Hagop M.; Ro, Jae Y.; Hopfer, Roy L.; Rolston, Kenneth V. I.; Fainstein, Victor; Bodey, Gerald P.

doi:10.1097/00005792-198803000-00001

Cited by 181 publications

(104 citation statements)

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“…These results suggest that both methods can identify itraconazole-resistant isolates of Aspergillus. Both methods also yielded high itraconazole MICs for Fusarium spp., P. lilacinus, S. prolificans, and T. longibrachiatum (Table TABLE 3 2); and these results are comparable to those determined by other procedures for these species (1,2,7,8,27). E-test results have not been published for P. lilacinus, R. arrhizus, or T. longibrachiatum, and the dematiaceous species (except W. dermatitidis) evaluated in the study.…”

Section: Vol 39 2001 Comparison Of E-test and Nccls M38-p For Mold supporting

confidence: 84%

“…It has been suggested that amphotericin B MICs are not good predictors of the clinical response to treatment with this agent in patients with disseminated fusarial infections. In 56 of 73 patients who failed amphotericin B therapy for disseminated fusarial infection, the MICs for the infecting isolates were indiscriminately low (Յ1.0 g/ml) or high (Ն2 g/ml) (2,16). However, in vitro testing was performed in those studies by using nonstandardized procedures.…”

Section: Vol 39 2001 Comparison Of E-test and Nccls M38-p For Mold mentioning

confidence: 99%

“…A higher incidence of fungal infections has been documented since the 1980s with the parallel emergence of either new fungal pathogens or fungi that were considered nonpathogenic as etiologic agents of systemic disease, especially in the immunocompromised host (2,4,8,16,27,28,31). Although the volume of disseminated infections caused by the filamentous fungi (molds) is lower than that caused by yeasts, their higher incidence and the increased resistance of molds to established antifungal agents (2, 4, 9, 10, 14-16, 18, 27, 31) warrant the evaluation of the in vitro susceptibilities of these fungi to both established and investigational agents.…”

mentioning

confidence: 99%

“…Aspergillus fumigatus is responsible for the majority (85 to 90%) of the different clinical manifestations of severe mold infections (9). However, other Aspergillus spp., Fusarium spp., Scedosporium apiospermum (Pseudallescheria boydii), Scedosporium prolificans, and less common molds have become important emerging pathogens (2,4,15,18,27,28).…”

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confidence: 99%

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Comparison of the E-test with the NCCLS M38-P Method for Antifungal Susceptibility Testing of Common and Emerging Pathogenic Filamentous Fungi

2001

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The National Committee for Clinical Laboratory Standards (NCCLS) M38-P method describes standard parameters for testing the fungistatic antifungal activities (MICs) of established agents against filamentous fungi (molds). The present study evaluated the in vitro fungistatic activities of itraconazole and amphotericin B by the E-test and the NCCLS M38-P microdilution method against 186 common and emerging pathogenic molds (123 isolates of Aspergillus spp. [five species], 16 isolates of Fusarium spp. [two species], 4 Paecilomyces lilacinus isolates, 5 Rhizopus arrhizus isolates, 15 Scedosporium spp., 18 dematiaceous fungi, and 5 Trichoderma longibrachiatum isolates). The agreement between the methods for amphotericin B MICs ranged from 70% for Fusarium solani to >90% for most of the other species after the first reading; agreement was dependent on both the incubation time and the species being evaluated. Major discrepancies between the amphotericin B MICs determined by the E-test and the NCCLS M38-P method were demonstrated for three of the five species of Aspergillus tested and the two species of Fusarium tested. This discrepancy was more marked after 48 h of incubation; the geometric mean MICs determined by the E-test increased between 24 and 48 h from between 1.39 and 3.3 g/ml to between 5.2 and >8 g/ml for Aspergillus flavus, Aspergillus fumigatus, and Aspergillus nidulans. The agreement between the itraconazole MICs determined by the E-test and the NCCLS M38-P method ranged from 83.3% for A. nidulans to >90% for all the other species tested; the overall agreement was higher (92.7%) than that for amphotericin B (87.9%). The agreement was less dependent on the incubation time. Clinical trials need to be conducted to establish the role of the results of either the E-test or the NCCLS M38-P method in vitro for molds with the two agents as predictors of clinical outcome.

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Section: Vol 39 2001 Comparison Of E-test and Nccls M38-p For Mold supporting

confidence: 84%

Section: Vol 39 2001 Comparison Of E-test and Nccls M38-p For Mold mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Comparison of the E-test with the NCCLS M38-P Method for Antifungal Susceptibility Testing of Common and Emerging Pathogenic Filamentous Fungi

2001

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“…These are fi lamentous, cosmopolitan, saprophytic or opportunistic plant parasites, which can be found in fruit, seeds and soil (Putzke & Putzke 1998, Almeida et al 2005. Some species are considered human opportunistic pathogens causing superfi cial and systemic infections, mainly when the patient is immunodefi cient (Anaissie et al 1988).…”

Section: Fusarium Sppmentioning

confidence: 99%