The emerging role of GATA transcription factors in development and disease

Lentjes, Marjolein H.F.M.; Niessen, Hanneke E.C.; Akiyama, Yoshimitsu; Bruïne, Adriaan P. de; Melotte, Veerle; Engeland, Manon van

doi:10.1017/erm.2016.2

Cited by 202 publications

(181 citation statements)

References 181 publications

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“…In vertebrates, six members are present (GATA1–6) and are divided into two subgroups: the first, GATA1/2/3, are mainly expressed in the hematopoietic and central nervous systems and are required for differentiation of mesodermal and ectodermal‐derived tissues. The second subgroup includes GATA4/5/6, which are important for differentiation of embryonic stem cells and epithelial cells in the adult, in addition to their major role in the development of the cardiovascular system . However, despite their classification into two groups, all six GATA factors play significant and nonredundant roles in a variety of organs and structures, as outlined in Table .…”

Section: The Gata Family Of Transcription Factorsmentioning

confidence: 99%

“…They each contain an N‐terminal transactivation domain required for gene activation or repression, a DNA binding domain consisting of two ZFs and a C‐terminal domain containing a nuclear localization sequence. They recognize and bind to (A/T)GATA(A/G) sequences . Their ZF domains are involved in mediating the majority known of protein–protein interactions and are more than 70% conserved across species.…”

Section: The Gata Family Of Transcription Factorsmentioning

confidence: 99%

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From embryogenesis to adulthood: Critical role for GATA factors in heart development and function

2019

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Cardiac development is governed by a complex network of transcription factors (TFs) that regulate cell fates in a spatiotemporal manner. Among these, the GATA family of zinc finger TFs plays prominent roles in regulating the development of the myocardium, endocardium, and outflow tract. This family comprises six members three of which, GATA4, 5, and 6, are predominantly expressed in cardiac cells where they activate specific downstream gene targets via interactions with one another and with other TFs and signaling molecules. Their critical function in heart formation is evidenced by the phenotypes of animal models lacking these factors and by the broad spectrum of human congenital heart diseases associated with mutations in their genes. Similarly, in the postnatal heart, these proteins play significant and nonredundant roles in cardiac function, regulating adaptive stress responses including cardiomyocyte hypertrophy and survival, as well as endothelial homeostasis and angiogenesis. As such, decreased expression of either GATA4, 5, or 6 results in impaired cardiovascular homeostasis and increased risk of premature and serious cardiovascular events such as hypertension, arrhythmia, aortopathy, and heart failure. Although a great deal of progress has been made in understanding GATA‐dependent regulatory processes in the heart, the molecular mechanisms underlying the specificity of GATA factors and their upstream regulation remain incompletely understood. The knowledge and tools developed since their discovery 25 years ago should accelerate progress toward further elucidation of their mechanisms of action in health and disease. This in turn will greatly improve diagnosis and care for the millions of individuals affected by congenital and acquired cardiac disease worldwide.

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Section: The Gata Family Of Transcription Factorsmentioning

confidence: 99%

Section: The Gata Family Of Transcription Factorsmentioning

confidence: 99%

From embryogenesis to adulthood: Critical role for GATA factors in heart development and function

2019

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“…Heterozygous GATA2 mutations that reduce or abrogate GATA2 transcriptional activity resulted in four human syndromes often associated with myelodysplastic syndrome (MDS)/acute myeloid leukemia (AML): (a) monocytopenia/ Mycobacterium avium complex; (b) dendritic cell, monocyte, B and natural killer lymphoid deficiency; (c) Emberger's syndrome; and (d) familial MDS/AML. The first three disorders cause alterations in the immune system (i.e., low monocyte, B cell, NK cell, and dendritic cell counts) and thus indicate that GATA2 also has an important role in the development of the immune system . Activating GATA2 mutations have been identified in chronic myeloid leukemia and were also associated with an enhanced inhibitory effect on PU.1—a transcription factor essential for myeloid cell differentiation …”

Section: Gata2mentioning

confidence: 99%

GATA factor transcriptional activity: Insights from genome‐wide binding profiles

Romano

Miccio

2019

IUBMB Life

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The members of the GATA family of transcription factors have homologous zinc fingers and bind to similar sequence motifs. Recent advances in genome-wide technologies and the integration of bioinformatics data have led to a better understanding of how GATA factors regulate gene expression; GATA-factor-induced transcriptional and epigenetic changes have now been analyzed at unprecedented levels of detail.Here, we review the results of genome-wide studies of GATA factor occupancy in human and murine cell lines and primary cells (as determined by chromatin immunoprecipitation sequencing), and then discuss the molecular mechanisms underlying the mediation of transcriptional and epigenetic regulation by GATA factors. K E Y W O R D S

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“…GATA has been identified as one of the transcription factors that play an essential role during epithelial proliferation [6–8], which comprised family members sharing highly conserved zinc fingers that recognize the motif WGATAR to mediate DNA binding and protein interactions [9]. …”

Section: Introductionmentioning

confidence: 99%

GATA3 and TRPS1 are distinct biomarkers and prognostic factors in breast cancer: database mining for GATA family members in malignancies

et al. 2017

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GATA transcription factors are zinc finger DNA binding proteins that activate transcription during development and cell differentiation. To date, 7 members of GATA family have been reported. However, the expression patterns and the exact roles of distinct GATA family members contributing to tumorigenesis and progression of breast cancer (BC) remain to be elucidated. Here, we studied the expression of GATA transcripts in a variety of tumor types compared with the normal controls using the ONCOMINE and GOBO databases, along with their corresponding expression profiles in an array of cancer cell lines through CCLE analysis. Based on Kaplan-Meier plotter, we further investigated the prognostic values of GATA members specifically high expressed in BC patients. It was found that, when compared with normal tissues, GATA3 and TRPS1 were distinctly high expressed in BC patients among all GATA members. GATA3 expression was significantly associated with ESR1, while TRPS1 was correlated with ERBB2. In survival analysis, GATA3 and TRPS1 mRNA high expressions were correlated to better survival in BC patients, and TRPS1 high expression was significantly associated with longer RFS in patients who have received chemotherapy. These results suggest that GATA3 and TRPS1 are distinct biomarkers and essential prognostic factors for breast cancer.

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The emerging role of GATA transcription factors in development and disease

Cited by 202 publications

References 181 publications

From embryogenesis to adulthood: Critical role for GATA factors in heart development and function

From embryogenesis to adulthood: Critical role for GATA factors in heart development and function

GATA factor transcriptional activity: Insights from genome‐wide binding profiles

GATA3 and TRPS1 are distinct biomarkers and prognostic factors in breast cancer: database mining for GATA family members in malignancies

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