2022
DOI: 10.3389/fnagi.2022.987174
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The emerging role of long non-coding RNAs, microRNAs, and an accelerated epigenetic age in Huntington’s disease

Abstract: Huntington’s disease (HD) is a dominantly inherited neurodegenerative disease with variable clinical manifestations. Recent studies highlighted the contribution of epigenetic alterations to HD progress and onset. The potential crosstalk between different epigenetic layers and players such as aberrant expression of non-coding RNAs and methylation alterations has been found to affect the pathogenesis of HD or mediate the effects of trinucleotide expansion in its pathophysiology. Also, microRNAs have been assesse… Show more

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Cited by 11 publications
(4 citation statements)
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References 84 publications
(104 reference statements)
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“…In HD, several studies have been focused on the exploration of brain and CSF miRNAs expression [39][40][41] . However, little information is available regarding dynamic changes of sRNAs in plasma, and none has studied plasma-EVs as a source of biomarkers.…”
Section: Discussionmentioning
confidence: 99%
“…In HD, several studies have been focused on the exploration of brain and CSF miRNAs expression [39][40][41] . However, little information is available regarding dynamic changes of sRNAs in plasma, and none has studied plasma-EVs as a source of biomarkers.…”
Section: Discussionmentioning
confidence: 99%
“…25,26 One such interaction has been identified between miRNAs and DNA methylation, where miRNA expression is regulated by DNA methylation at miRNA promoters, and aberrant methylation patterns at these promoters have been associated with aging-related diseases, including cancer and Huntington's disease, among other diseases. [26][27][28][29] However, it is not yet understood if EAA, measured via epigenetic clocks, is associated with miRNA expression.…”
Section: Epigenetics Insightsmentioning
confidence: 99%
“…Similarly, in HD, Ras homolog enriched in striatum (Rhes) affects the development of HD pathology through various signaling pathways in the body. miR-101 can bind to the 3′-UTR of Rhes mRNA, inhibit the expression of Rhes, and prevent the progression of HD disease [ 22 , 23 ]. Autophagy vesicles are not common in the normal brain but are enriched in the AD brain.…”
Section: Introductionmentioning
confidence: 99%