The Emerging Role of Menstrual-Blood-Derived Stem Cells in Endometriosis

Cordeiro, Mariana Robalo; Carvalhos, Carlota Anjinho; Figueiredo-Dias, Margarida

doi:10.3390/biomedicines11010039

Cited by 14 publications

(7 citation statements)

References 22 publications

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“…From that time, the menstrual blood has attracted huge scientific interest, leading to a permanently increasing number of different research studies and possible applications of MenSCs in both experimental and clinical practices. In addition, the MenSCs, due to their origin, could have a higher level of stemness and better differentiation potential [ 49 ]. It has been shown that MenSCs, similar to other types of MSCs, possess MSCs-typical qualities such as high proliferative potential, self-renewal property and a multipotent differentiation into osteogenic, adipogenic and chondrogenic directions [ 48 ].…”

Section: Discussionmentioning

confidence: 99%

The Effect of CaV1.2 Inhibitor Nifedipine on Chondrogenic Differentiation of Human Bone Marrow or Menstrual Blood-Derived Mesenchymal Stem Cells and Chondrocytes

Uzielienè

Bironaitė

Mikšiūnas

et al. 2023

IJMS

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Cartilage is an avascular tissue and sensitive to mechanical trauma and/or age-related degenerative processes leading to the development of osteoarthritis (OA). Therefore, it is important to investigate the mesenchymal cell-based chondrogenic regenerating mechanisms and possible their regulation. The aim of this study was to investigate the role of intracellular calcium (iCa2+) and its regulation through voltage-operated calcium channels (VOCC) on chondrogenic differentiation of mesenchymal stem/stromal cells derived from human bone marrow (BMMSCs) and menstrual blood (MenSCs) in comparison to OA chondrocytes. The level of iCa2+ was highest in chondrocytes, whereas iCa2+ store capacity was biggest in MenSCs and they proliferated better as compared to other cells. The level of CaV1.2 channels was also highest in OA chondrocytes than in other cells. CaV1.2 antagonist nifedipine slightly suppressed iCa2+, Cav1.2 and the proliferation of all cells and affected iCa2+ stores, particularly in BMMSCs. The expression of the CaV1.2 gene during 21 days of chondrogenic differentiation was highest in MenSCs, showing the weakest chondrogenic differentiation, which was stimulated by the nifedipine. The best chondrogenic differentiation potential showed BMMSCs (SOX9 and COL2A1 expression); however, purposeful iCa2+ and VOCC regulation by blockers can stimulate a chondrogenic response at least in MenSCs.

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Section: Discussionmentioning

confidence: 99%

The Effect of CaV1.2 Inhibitor Nifedipine on Chondrogenic Differentiation of Human Bone Marrow or Menstrual Blood-Derived Mesenchymal Stem Cells and Chondrocytes

Uzielienè

Bironaitė

Mikšiūnas

et al. 2023

IJMS

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“…Various hypotheses have been formulated for the development of endometriosis, such as implantation, metaplastic, and other hypotheses, but the retrograde menstruation theory still has the most supporters [ 162 , 163 ]. It assumes that fragments of the uterine mucosa may travel backwards through the fallopian tubes to the peritoneal cavity, where they may be implanted, and then grow and infiltrate adjacent structures.…”

Section: Egcg In the Treatment Of Benign Gynecological Diseasesmentioning

confidence: 99%

Epigallocatechin Gallate for the Treatment of Benign and Malignant Gynecological Diseases—Focus on Epigenetic Mechanisms

Włodarczyk,

Ciebiera,

Nowicka

et al. 2024

Nutrients

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The most common malignant gynecologic diseases are cervical, uterine, ovarian, vaginal, and vulvar cancer. Among them, ovarian cancer causes more deaths than any other cancer of the female reproductive system. A great number of women suffer from endometriosis, uterine fibroids (UFs), adenomyosis, dysmenorrhea, and polycystic ovary syndrome (PCOS), which are widespread benign health problems causing troublesome and painful symptoms and significantly impairing the quality of life of affected women, and they are some of the main causes of infertility. In addition to the available surgical and pharmacological options, the effects of supporting standard treatment with naturally occurring compounds, mainly polyphenols, are being studied. Catechins are responsible for the majority of potential health benefits attributed to green tea consumption. Epigallocatechin gallate (EGCG) is considered a non-toxic, natural compound with potential anticancer properties. Antioxidant action is its most common function, but attention is also drawn to its participation in cell division inhibition, apoptosis stimulation and epigenetic regulation. In this narrative review, we describe the role of EGCG consumption in preventing the development of benign reproductive disorders such as UF, endometriosis, and PCOS, as well as malignant gynecologic conditions. We discuss possible epigenetic mechanisms that may be related to the action of EGCG.

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“…The most favored one describes how retrograde menstruation through the fallopian tubes could invade the peritoneal mesothelium, leading to diffuse implants of the disease and its blood supply for survival and growth [ 6 , 7 ]. The stem cell theory for endometriosis pathogenesis, supported by the consensual mechanism of retrograde menstruation, highlights the recognized importance that menstrual blood-derived stem cells have gained by potentially being directly related to the genesis, development, and maintenance of ectopic endometriotic lesions [ 8 ]. Endometriosis can be disabling and strongly compromise life quality along with the critical associated social-economic cost.…”

Section: Introductionmentioning

confidence: 99%

Superficial Peritoneal Endometriosis Vaporization Using a CO2 Laser: A Long-Term Single-Center Experience

Di Michele,

Bramante,

Angioni

et al. 2024

JCM

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Background: The validation of laser usage during laparoscopic procedures, notably by Camran Nezhat in the late 1980s, has been significant. Lasers offer precision and depth control in tissue vaporization without bleeding. Surgical intervention remains central in managing endometriosis-associated pain and infertility, especially for patients unresponsive to hormonal therapy. Methods: This retrospective cohort study included 200 patients with superficial peritoneal endometriosis (SPE) who underwent laparoscopic laser vaporization. Surgery was performed using a CO2 laser, and histological confirmation of endometriosis was obtained for all cases. Pain scores and SF-36 questionnaire domains were assessed preoperatively and postoperatively. Fertility outcomes were evaluated among patients desiring pregnancy. Results: Significant improvements in pain score and SF-36 questionnaire domains were observed postoperatively (p-value < 0.01), indicating enhanced quality of life. Among infertile patients with an active desire for pregnancy, surgical treatment showed an overall pregnancy rate after surgery of 93.7% (p-value < 0.01), including 75.7% natural pregnancies and 24.3% IVF. Laser vaporization enabled precise lesion removal with minimal tissue damage, short operative time, and minimal blood loss. Conclusions: Laparoscopic laser vaporization is an effective treatment for SPE, offering pain relief, improved quality of life, and favorable fertility outcomes. Further research is needed to validate these results in terms of pain control and fertility.

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The Emerging Role of Menstrual-Blood-Derived Stem Cells in Endometriosis

Cited by 14 publications

References 22 publications

The Effect of CaV1.2 Inhibitor Nifedipine on Chondrogenic Differentiation of Human Bone Marrow or Menstrual Blood-Derived Mesenchymal Stem Cells and Chondrocytes

The Effect of CaV1.2 Inhibitor Nifedipine on Chondrogenic Differentiation of Human Bone Marrow or Menstrual Blood-Derived Mesenchymal Stem Cells and Chondrocytes

Epigallocatechin Gallate for the Treatment of Benign and Malignant Gynecological Diseases—Focus on Epigenetic Mechanisms

Superficial Peritoneal Endometriosis Vaporization Using a CO2 Laser: A Long-Term Single-Center Experience

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