The emerging role of miRNA clusters in breast cancer progression

Kandettu, Amoolya; Radhakrishnan, Raghu; Chakrabarty, Sanjiban; Sriharikrishnaa, S.; Kabekkodu, Shama Prasada

doi:10.1016/j.bbcan.2020.188413

Cited by 53 publications

(42 citation statements)

References 203 publications

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“…With the development of molecular biology, the detection of biomarkers can provide an effective assessment of the prognosis of LC. e expression of miRNA is related to the growth, proliferation, migration, and other processes of tumor cells and affects the occurrence and prognosis of many diseases including tumors [22][23][24]. Many studies are limited to the clinical analysis of patients with SP and LC, while ignoring the importance of clinical diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Study on Serum miR-204 Expression Levels in Patients with Severe Pneumonia and Patients with Primary Bronchial Lung Cancer and Its Diagnostic Value

Zheng¹,

Huang

2021

Evidence-Based Complementary and Alternative Medicine

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Objective. To analyze the expression and clinical significance of miR-204 in the serum of patients with severe pneumonia (SP) and primary bronchial lung cancer (LC). Methods. 65 SP patients and 43 primary bronchial LC patients who were treated in the hospital from January 2017 to December 2018 were randomly selected as the SP group and LC group. At the same time, healthy patients from the physical examination department of the hospital were selected. 65 cases were the control group. QRT-PCR detected serum miR-204 expression and compared the differences between groups. The pathological data of patients were collected, and the relationship between serum miR-204 and the patient’s pathological data was compared; the area under the ROC curve and Kaplan–Meier curve were used to evaluate the diagnostic value of serum miR-204 for the two conditions and to explore the relationship between serum miR-204 and prognosis. Results. The serum miR-204 of the SP group was (0.43 ± 0.09), the serum miR-204 of the LC group was (0.40 ± 0.10), the serum miR-204 of the control group was (1.00 ± 0.09), and the miR-204 level of was significantly higher than that of the control group, and the difference between the groups was statistically significant ( P < 0.05). There was no significant difference in serum miR-204 levels between the SP group and the LC group ( P > 0.05). Serum miR-204 levels in SP patients with cumulative organs ≥3 were higher than those with cumulative organs <3, and the difference was statistically significant ( P < 0.001). In the LC group, in patients with stage III to IV and low and undifferentiated patients, the level of miR-204 was higher than that of stage I∼II and high and moderately differentiated patients, and the difference was statistically significant ( P < 0.001). The level of miR-204 in the two groups of patients (0.89 ± 0.10, 0.83 ± 0.13) who died of illness was significantly higher than that of the surviving patients (1.00 ± 0.11, 1.00 ± 0.10), and the difference was statistically significant ( P < 0.05); the survival rate of patients with high expression of miR-204 was higher than that of patients with low expression. The AUC of serum miR-204 level to SP and LC was 0.766 and 0.818, respectively. Conclusion. The level of miR-204 in the serum of SP patients and patients with primary bronchial LC was significantly lower than that of healthy people, and patients who died were lower than those who survived; the miR-204 in serum has a good diagnostic value for SP and LC and is related to the survival and prognosis of patients.

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Section: Discussionmentioning

confidence: 99%

Study on Serum miR-204 Expression Levels in Patients with Severe Pneumonia and Patients with Primary Bronchial Lung Cancer and Its Diagnostic Value

Zheng¹,

Huang

2021

Evidence-Based Complementary and Alternative Medicine

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“…Thus, miRNAs have been linked to various signal pathways through the regulation of these target genes, which in turn regulates crucial biological processes that are often recognized as hallmarks of cancer, such as proliferation, invasion, metastasis, apoptosis, autophagy, and differentiation [ 6 , 7 , 9 , 10 , 11 , 12 ]. Additionally, miRNAs have been found to be dysregulated in many disease models, such as cardiovascular diseases and neurodegenerative diseases, as well as leukemia, and particularly in cancer [ 13 , 14 , 15 , 16 ]. Overall, the functions of miRNA vary greatly, and are different depending on the specific miRNA’s pathological type and physiological environment, which can make them carcinogenic factors to promote tumor progression, or as a tumor suppressors, to inhibit tumor cell metastasis.…”

Section: Introductionmentioning

confidence: 99%

MicroRNA 320, an Anti-Oncogene Target miRNA for Cancer Therapy

Liang

Tang

2021

Biomedicines

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MicroRNAs are a set of highly conserved non-coding RNAs that control gene expression at the post-transcriptional/translational levels by binding to the 3′-UTR of diverse target genes. Increasing evidence indicates that miRNAs not only play a vital role in many biological processes, but they are also frequently deregulated in pathological conditions, including cancer. The miR-320 family is one of many tumor suppressor families and is composed of five members, which has been demonstrated to be related to the repression of epithelial-mesenchymal transition (EMT) inhibition, cell proliferation, and apoptosis. Moreover, this family has been shown to regulate drug resistance, and act as a potential biomarker for the diagnosis, prognosis, and prediction of cancer. In this review, we summarized recent research with reference to the tumor suppressor function of miR-320 and the regulation mechanisms of miR-320 expression. The collected evidence shown here supports that miR-320 may act as a novel biomarker for cancer prognosis and therapeutic response to cancer treatment.

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“…MicroRNAs (miRNAs) are small non-coding RNAs, about 22 nucleotides long, were reported to exert pivotal roles in the progression of human cancers, including BC [3,[16][17][18]. For instance, miR-944 inhibited the motility of colorectal cancer cells by modulating MET transcriptional regulator MACC1 [19].…”

Section: Introductionmentioning

confidence: 99%

Hsa_circ_0001982 promotes the progression of breast cancer through miR-1287-5p/MUC19 axis under hypoxia

Qiu

Liu

2021

World J Surg Onc

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Background Breast cancer (BC) is the most commonly malignant tumor among women worldwide. Many studies have reported that circular RNAs (circRNAs) were participated in the regulation of multiple cancers development. However, the mechanism underlying hsa_circ_0001982 in breast cancer development is still unclear. Methods Quantitative real-time polymerase chain reaction (qRT-PCR) was used to detect the levels of circ_0001982, microRNA-1287-5p (miR-1287-5p), and mucin 19 (MUC19) in BC tissues and cells under hypoxia. Moreover, glycolysis was evaluated by glucose consumption, lactic acid production, and hexokinase II (HK2) protein levels. The protein levels of cyclin D1, proliferating cell nuclear antigen (PCNA), and HK2 were determined by western blot assay. Cell proliferation, migration, and invasion were assessed by 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-h-tetrazolium bromide (MTT) and transwell assays, respectively. The relationship between miR-1287-5p and circ_0001982 or MUC19 was predicted using starbase v3.0 or Targetscan, and verified by dual-luciferase reporter assay and RNA binding protein immunoprecipitation (RIP) assay. The xenograft model in nude mice was established to examine the effect of circ_0001982 in vivo. Results The levels of circ_0001982 and MUC19 were upregulated, while miR-1287-5p was downregulated in BC tissues and cells under hypoxia. Knockdown of circ_0001982 hindered glycolysis, cell viability, migration, and invasion of BC cells under hypoxia. Mechanistic studies discovered that circ_0001982 could act as a sponge for miR-1287-5p to enhance MUC19 expression in BC cells. In addition, circ_0001982 silencing reduced xenograft tumor growth by regulating miR-1287-5p/MUC19 axis. Conclusion Circ_0001982 affected BC cells glycolysis, proliferation, migration, and invasion through miR-1287-5p/MUC19 axis under hypoxia.

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The emerging role of miRNA clusters in breast cancer progression

Cited by 53 publications

References 203 publications

Study on Serum miR-204 Expression Levels in Patients with Severe Pneumonia and Patients with Primary Bronchial Lung Cancer and Its Diagnostic Value

Study on Serum miR-204 Expression Levels in Patients with Severe Pneumonia and Patients with Primary Bronchial Lung Cancer and Its Diagnostic Value

MicroRNA 320, an Anti-Oncogene Target miRNA for Cancer Therapy

Hsa_circ_0001982 promotes the progression of breast cancer through miR-1287-5p/MUC19 axis under hypoxia

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