The emerging role of oxidative stress in regulating autophagy: applications of cancer therapy

Abstract

Emerging evidences show that autophagy, as a major cellular adaptive degradation mechanism, is involved in tumorigenesis, cell aging, inflammation and neurodegeneration. It has been reported that multiple stresses including nutrient deprivation, pathogen infection, oxidative stress, endoplasmic reticulum (ER) stress and metabolic stress can influence cellular autophagy, leading to distinct cell fate. Although numerous studies have been employed to elucidate the probable issues, the underlying mechanism of the initiation and maturation of autophagy remains unclear. Herein, we discuss the possible cause and effect relationship between oxidative stress and autophagy, as well as the potential molecular mechanisms that oxidative stress may mediate the role of autophagy in cancer therapy, therefore shed some light on new therapeutic strategies of cancer.

Nicotinamide N-methyltransferase inhibits autophagy induced by oxidative stress through suppressing the AMPK pathway in breast cancer cells

“…In recent decades, autophagy has been verified to play a vital role in cancer progression and in response to radiation and chemotherapy, which helps us to shed some light on ways to develop novel strategies for cancer therapy [16]. However, it is generally thought that autophagy has both positive and negative roles in cancer progression, which depends on the particular type of tumour and the stage of cancer progression.…”

Differences of basic and induced autophagic activity between K562 and K562/ADM cells

“…Abnormal basal autophagy can lead to various human diseases including cancer, neurodegenerative disorders, autoimmunity disease and inflammation (12)(13)(14)(15). Autophagy can be induced in response to several stressors including: nutrient deprivation, chemotherapeutics, hypoxia, pathogen infection and endoplasmic reticulum stress (16)(17)(18). A larger body of research has reported that autophagy which is promoted by chemotherapeutic drugs in cancer cells, is related to drug-resistance of tumor cells (19)(20)(21).…”

Se Alleviated Oxidative Stress-Mediated Complex Poisoning Mechanism in Pb-Treated Chicken Kidneys: Inflammation, Heat Shock Response, and Autophagy

“…Autophagy is an intracellular lysosomal degradation process, which plays an important role in regulating normal cell homeostasis, and is considered as one of cellular defense against increased oxidative stress [52]. Song et al (2017) reported that autophagy contributed to Pb-induced nephrotoxicity in primary rat proximal tubular cells [53].…”