The emerging role of RNA editing in plasticity

Rosenthal, Joshua J. C.

doi:10.1242/jeb.119065

Cited by 71 publications

(70 citation statements)

References 128 publications

(133 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…RNA editing is a post-transcriptional event that recodes hereditary information by changing the nucleotide sequence of RNA molecules (Farajollahi and Maas 2010;Rosenthal 2015). Although various RNA editing systems that target major types of cellular RNA have been identified in eukaryotes (Farajollahi and Maas 2010;Knoop 2011;Gray 2012), only two types of RNA editing are known to cause changes in nuclear-encoded messenger RNA (mRNA).…”

Section: [Supplemental Materials Is Available For This Article]mentioning

confidence: 99%

“…However, editing events resulting in protein sequence recoding are not common in animals. To date, the majority of studies on the functional consequences of recoding editing are related to genes important for animal nervous systems (Hood and Emeson 2012;Rosenthal 2015). A-to-I editing of ligand-and voltage-gated ion channels and neurotransmitter receptors in invertebrates (Patton et al 1997;Palladino et al 2000) and vertebrates (Sommer et al 1991;Seeburg 1996) are among the best-studied ADAR-mediated recoding events.…”

Section: [Supplemental Materials Is Available For This Article]mentioning

confidence: 99%

“…Although most editing sites do not affect the primary sequences of coding proteins, only approximately 50 recoding events in mice (Danecek et al 2012), 645 in Drosophila (St Laurent et al 2013, and eight in Caenorhabditis elegans (Zhao et al 2015) have been identified. One remarkable exception among animals that have been studied for A-to-I editing is squid, in which a total of 57,108 recoding RNA editing sites were identified in its nervous system (Alon et al 2015), raising the question about the prevalence of recoding RNA editing events in other animal lineages (Rosenthal 2015).…”

Section: [Supplemental Materials Is Available For This Article]mentioning

confidence: 99%

See 2 more Smart Citations

Genome-wide A-to-I RNA editing in fungi independent of ADAR enzymes

et al. 2016

View full text Add to dashboard Cite

Yeasts and filamentous fungi do not have adenosine deaminase acting on RNA (ADAR) orthologs and are believed to lack A-to-I RNA editing, which is the most prevalent editing of mRNA in animals. However, during this study with the PUK1 (FGRRES_01058) pseudokinase gene important for sexual reproduction in Fusarium graminearum, we found that two tandem stop codons, UA1831GUA1834G, in its kinase domain were changed to UG1831GUG1834G by RNA editing in perithecia. To confirm A-to-I editing of PUK1 transcripts, strand-specific RNA-seq data were generated with RNA isolated from conidia, hyphae, and perithecia. PUK1 was almost specifically expressed in perithecia, and 90% of transcripts were edited to UG1831GUG1834G. Genome-wide analysis identified 26,056 perithecium-specific A-to-I editing sites. Unlike those in animals, 70.5% of A-to-I editing sites in F. graminearum occur in coding regions, and more than two-thirds of them result in amino acid changes, including editing of 69 PUK1-like pseudogenes with stop codons in ORFs. PUK1 orthologs and other pseudogenes also displayed stage-specific expression and editing in Neurospora crassa and F. verticillioides. Furthermore, F. graminearum differs from animals in the sequence preference and structure selectivity of A-to-I editing sites. Whereas A's embedded in RNA stems are targeted by ADARs, RNA editing in F. graminearum preferentially targets A's in hairpin loops, which is similar to the anticodon loop of tRNA targeted by adenosine deaminases acting on tRNA (ADATs). Overall, our results showed that A-to-I RNA editing occurs specifically during sexual reproduction and mainly in the coding regions in filamentous ascomycetes, involving adenosine deamination mechanisms distinct from metazoan ADARs.

show abstract

Section: [Supplemental Materials Is Available For This Article]mentioning

confidence: 99%

Section: [Supplemental Materials Is Available For This Article]mentioning

confidence: 99%

Section: [Supplemental Materials Is Available For This Article]mentioning

confidence: 99%

See 1 more Smart Citation

Genome-wide A-to-I RNA editing in fungi independent of ADAR enzymes

et al. 2016

View full text Add to dashboard Cite

show abstract

“…In addition to the 5¢ end modifications, host RNAs are highly modified on internal nucleotides (Sarin and Leidel 2014;Rosenthal 2015). However, the function of only a few modifications has been elucidated to date.…”

Section: Generation and Properties Of Cellular Rnamentioning

confidence: 99%

Discrimination of Self and Non-Self Ribonucleic Acids

Gebhardt

Laudenbach

Pichlmair

2017

Journal of Interferon & Cytokine Research

View full text Add to dashboard Cite

Most virus infections are controlled through the innate and adaptive immune system. A surprisingly limited number of so-called pattern recognition receptors (PRRs) have the ability to sense a large variety of virus infections. The reason for the broad activity of PRRs lies in the ability to recognize viral nucleic acids. These nucleic acids lack signatures that are present in cytoplasmic cellular nucleic acids and thereby marking them as pathogen-derived. Accumulating evidence suggests that these signatures, which are predominantly sensed by a class of PRRs called retinoic acid-inducible gene I (RIG-I)-like receptors and other proteins, are not unique to viruses but rather resemble immature forms of cellular ribonucleic acids generated by cellular polymerases. RIG-I-like receptors, and other cellular antiviral proteins, may therefore have mainly evolved to sense nonprocessed nucleic acids typically generated by primitive organisms and pathogens. This capability has not only implications on induction of antiviral immunity but also on the function of cellular proteins to handle selfderived RNA with stimulatory potential.

show abstract

“…Its focus, however, is on the significance of non-coding, repetitive RNA editing and on the interactions between the RNA-editing and RNAi mechanisms. For reviews focusing on the relevance of A-to-I RNA editing to brain functions, viral infection and human diseases, see REFS 4,5,27–35. For reviews on other types of RNA editing, see REFS 36–39.…”

mentioning

confidence: 99%

A-to-I editing of coding and non-coding RNAs by ADARs

Nishikura

2015

Nat Rev Mol Cell Biol

815

854

View full text Add to dashboard Cite

Adenosine deaminases acting on RNA (ADARs) convert adenosine to inosine in double-stranded RNA. This A-to-I editing occurs not only in protein-coding regions of mRNAs, but also frequently in non-coding regions that contain inverted Alu repeats. Editing of coding sequences can result in the expression of functionally altered proteins that are not encoded in the genome, whereas the significance of Alu editing remains largely unknown. Certain microRNA (miRNA) precursors are also edited, leading to reduced expression or altered function of mature miRNAs. Conversely, recent studies indicate that ADAR1 forms a complex with Dicer to promote miRNA processing, revealing a new function of ADAR1 in the regulation of RNA interference.

show abstract

The emerging role of RNA editing in plasticity

Cited by 71 publications

References 128 publications

Genome-wide A-to-I RNA editing in fungi independent of ADAR enzymes

Genome-wide A-to-I RNA editing in fungi independent of ADAR enzymes

Discrimination of Self and Non-Self Ribonucleic Acids

A-to-I editing of coding and non-coding RNAs by ADARs

Contact Info

Product

Resources

About