The Emerging Role of Sfrp5 and Wnt5a in the Pathogenesis of Obesity: Implications for a Healthy Diet and Lifestyle

Koutaki, Diamanto; Michos, Athanasios; Bacopoulou, Flora; Charmandari, Evangelia

doi:10.3390/nu13072459

Cited by 28 publications

(25 citation statements)

References 87 publications

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“…28 Whereas some studies found Wnt5a was increased in obesity, others could not confirm these observations. 29 Consistent with the findings of Gerdes, 25 our study found that Wnt5a serum concentrations not increased in even severe obesity healthy volunteers. The possible reason may be the number of healthy volunteers in control group was small.…”

Section: Discussionsupporting

confidence: 91%

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Increased Level of Serum Wingless-Type Mouse Mammary Tumor Virus Integration Site Family Member 5a in Patients with Cutaneous Lichen Planus

Ren¹,

Ning²,

Zhang³

et al. 2022

JIR

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Purpose: Cutaneous lichen planus (CLP) is an autoinflammatory skin disorder, and it is associated with metabolic syndrome. Wingless-type mouse mammary tumor virus integration site family member 5a (Wnt5a) is a potential factor in metabolic complications and it was shown to be upregulated in CLP lesions. Whether Wnt5a is altered in the circulation of patients with CLP is unclear. This study aimed to measure serum Wnt5a level in patients with CLP and to assess its relationship with body mass index (BMI). Methods: We included 46 adult patients with CLP and 38 healthy adults as control. Serum Wnt5a was measured using enzyme-linked immunosorbent assay. Results: The mean serum Wnt5a was significantly higher in patients than controls (all P-value <0.001). The mean serum Wnt5a levels in obese (BMI between 30 and 40) patients were significantly higher than lean (BMI between 20 and 25) patients (P-value <0.001). Compared to lean patients with CLP, the concentration of serum Wnt5a levels was increased gradually with BMI score (all P-value <0.05). Conclusion:Serum Wnt5a might be a potential biomarker for CLP and it was associated with BMI. An increase in serum Wnt5a may contribute to the development of metabolic comorbidity in CLP patients.

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Section: Discussionsupporting

confidence: 91%

“…We did not detect the expression of the anti-inflammatory secreted frizzled-related protein 5 (SFRP5), a soluble Wnt5a receptor, always secreted by adipocytes from healthy subjects, and together with Wnt5a involved in the occurrence and development of obesity and inflammatory diseases. 29,30…”

Section: Discussionmentioning

confidence: 99%

Increased Level of Serum Wingless-Type Mouse Mammary Tumor Virus Integration Site Family Member 5a in Patients with Cutaneous Lichen Planus

Ren¹,

Ning²,

Zhang³

et al. 2022

JIR

View full text Add to dashboard Cite

show abstract

“…Recent studies have demonstrated that the pro-inflammatory adipokine wingless-type mouse mammary tumor virus integration site family member 5A (Wnt5a), together with the anti-inflammatory secreted frizzled-related protein 5 (Sfrp5), which both signal via the non-canonical Wnt pathway, play a key role in the pathogenesis of obesity and its metabolic complications [151,152]. The circulating levels of Wnt5a and its expression in VAT are increased in obesity [152,153], contributing to systemic and local inflammation [154].…”

Section: Wnt5amentioning

confidence: 99%

Obesity and Pancreatic Cancer: Insight into Mechanisms

Eibl

2021

Cancers

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The prevalence of obesity in adults and children has dramatically increased over the past decades. Obesity has been declared a chronic progressive disease and is a risk factor for a number of metabolic, inflammatory, and neoplastic diseases. There is clear epidemiologic and preclinical evidence that obesity is a risk factor for pancreatic cancer. Among various potential mechanisms linking obesity with pancreatic cancer, the adipose tissue and obesity-associated adipose tissue inflammation play a central role. The current review discusses selected topics and mechanisms that attracted recent interest and that may underlie the promoting effects of obesity in pancreatic cancer. These topics include the impact of obesity on KRAS activity, the role of visceral adipose tissue, intrapancreatic fat, adipose tissue inflammation, and adipokines on pancreatic cancer development. Current research on lipocalin-2, fibroblast growth factor 21, and Wnt5a is discussed. Furthermore, the significance of obesity-associated insulin resistance with hyperinsulinemia and obesity-induced gut dysbiosis with metabolic endotoxemia is reviewed. Given the central role that is occupied by the adipose tissue in obesity-promoted pancreatic cancer development, preventive and interceptive strategies should be aimed at attenuating obesity-associated adipose tissue inflammation and/or at targeting specific molecules that mechanistically link adipose tissue with pancreatic cancer in obese patients.

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“…ROS1 [250], WNT2 [251], PHLDA2 [252], WNT5A [253], HSD11B2 [254], CLDN1 [255], CYP24A1 [256], HRG (histidine rich glycoprotein) [257], TLR3 [258], THBS1 [259], TRPC6 [260], SELP (selectin P) [261], CLU (clusterin) [262], CDKN1A [263], ITGB1 [264], HLA-E [265], IL6R [266], TIMP1 [267], SERPINA1 [268], CD74 [269], PANX1 [270], STIM1 [271] and CXCR4 [272] were revealed to be correlated with disease outcome in patients with preeclampsia. Previously reported studies have shown that the expression of LBP (lipopolysaccharide binding protein) [273], MC1R [274], CXCL14 [275], RGN (regucalcin) [276], NPY2R [277], MFAP5 [278], WNT5A [279], EDA (ectodysplasin A) [280], THSD7A [281], NEUROD1 [282], SLIT2 [283], PPARGC1A [219], IGF1 [144], OSR1 [284], TLR3 [285], BMP7 [286], POSTN (periostin) [287], LRP1B [288], THBS1 [289], NOTCH2 [290]. LRP1 [291], CLU (clusterin) [292], SMAD3 [91], TGFB1 [293], APP (amyloid beta precursor protein) [294], ITGB2 [295], IL6R [296], TIMP1 [297], CD47 [298], CD74 [299], RARA (retinoic acid receptor alpha) [300], DOCK2 [301], F13A1 [302], IRF7 [303], STIM1 [304], CXCR4 [305], MGLL (monoglyceride lipase) [306], M6PR [307], USP22 [308] and CASP2 [309] were mainly involved in progression of obesity, but these genes might be novel targets for GDM.…”

Section: Discussionmentioning

confidence: 99%

Identification of differentially expressed genes and signaling pathways in gestational diabetes mellitus by integrated bioinformatics analysis

Vastrad¹,

Vastrad²

2021

Preprint

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Gestational diabetes mellitus (GDM) is a metabolic disorder during pregnancy. Numerous biomarkers have been identified that are linked with the occurrence and development of GDM. The aim of this investigation was to identify differentially expressed genes (DEGs) in GDM using a bioinformatics approach to elucidate their molecular pathogenesis. GDM associated expression profiling by high throughput sequencing dataset (GSE154377) was obtained from Gene Expression Omnibus (GEO) database including 28 normal pregnancy samples and 33 GDM samples. DEGs were identified using DESeq2. The gene ontology (GO) and REACTOME pathway enrichments of DEGs were performed by g:Profiler. Protein-protein interaction (PPI) networks were assembled with Cytoscape software and separated into modules using the PEWCC1 algorithm. MiRNA-hub gene regulatory network and TF-hub gene regulatory network were performed with the miRNet database and NetworkAnalyst database. Receiver Operating Characteristic (ROC) analyses was conducted to validate the hub genes. A total of 953 DEGs were identified, of which 478 DEGs were up regulated and 475 DEGs were down regulated. Furthermore, GO and REACTOME pathway enrichment analysis demonstrated that these DEGs were mainly enriched in multicellular organismal process, cell activation, formation of the cornified envelope and hemostasis. TRIM54, ELAVL2, PTN, KIT, BMPR1B, APP, SRC, ITGA4, RPA1 and ACTB were identified as key genes in the PPI network, miRNA-hub gene regulatory network and TF-hub gene regulatory network. TRIM54, ELAVL2, PTN, KIT, BMPR1B, APP, SRC, ITGA4, RPA1 and ACTB in GDM were validated using ROC analysis. This investigation provides further insights into the molecular pathogenesis of GDM, which might facilitate the diagnosis and treatment of GDM.

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The Emerging Role of Sfrp5 and Wnt5a in the Pathogenesis of Obesity: Implications for a Healthy Diet and Lifestyle

Cited by 28 publications

References 87 publications

Increased Level of Serum Wingless-Type Mouse Mammary Tumor Virus Integration Site Family Member 5a in Patients with Cutaneous Lichen Planus

Increased Level of Serum Wingless-Type Mouse Mammary Tumor Virus Integration Site Family Member 5a in Patients with Cutaneous Lichen Planus

Obesity and Pancreatic Cancer: Insight into Mechanisms

Identification of differentially expressed genes and signaling pathways in gestational diabetes mellitus by integrated bioinformatics analysis

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