The Emerging Role of SIRT7 in Glucose and Lipid Metabolism

Yamagata, Kazuya; Mizumoto, Tomoya; Yoshizawa, Tatsuya

doi:10.3390/cells13010048

Cells

2023

DOI: 10.3390/cells13010048

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The Emerging Role of SIRT7 in Glucose and Lipid Metabolism

Kazuya Yamagata,

Tomoya Mizumoto,

Tatsuya Yoshizawa

Abstract: Sirtuins (SIRT1–7 in mammals) are a family of NAD+-dependent lysine deacetylases and deacylases that regulate diverse biological processes, including metabolism, stress responses, and aging. SIRT7 is the least well-studied member of the sirtuins, but accumulating evidence has shown that SIRT7 plays critical roles in the regulation of glucose and lipid metabolism by modulating many target proteins in white adipose tissue, brown adipose tissue, and liver tissue. This review focuses on the emerging roles of SIRT7… Show more

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2024

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Cited by 4 publications

References 131 publications

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Role of miR-125b-5p in Modulating Placental SIRT7 Expression and Its Implications for Lipid Metabolism in Gestational Diabetes

Milan,

Anuradha,

Ramkumar

2024

Journal of Reproductive Immunology

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Role of miR-125b-5p in Modulating Placental SIRT7 Expression and Its Implications for Lipid Metabolism in Gestational Diabetes

Milan,

Anuradha,

Ramkumar

2024

Journal of Reproductive Immunology

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Metabolic mechanisms orchestrated by Sirtuin family to modulate inflammatory responses

Li,

Hao

et al. 2024

Front. Immunol.

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Maintaining metabolic homeostasis is crucial for cellular and organismal health throughout their lifespans. The intricate link between metabolism and inflammation through immunometabolism is pivotal in maintaining overall health and disease progression. The multifactorial nature of metabolic and inflammatory processes makes study of the relationship between them challenging. Homologs of Saccharomyces cerevisiae silent information regulator 2 protein, known as Sirtuins (SIRTs), have been demonstrated to promote longevity in various organisms. As nicotinamide adenine dinucleotide-dependent deacetylases, members of the Sirtuin family (SIRT1–7) regulate energy metabolism and inflammation. In this review, we provide an extensive analysis of SIRTs involved in regulating key metabolic pathways, including glucose, lipid, and amino acid metabolism. Furthermore, we systematically describe how the SIRTs influence inflammatory responses by modulating metabolic pathways, as well as inflammatory cells, mediators, and pathways. Current research findings on the preferential roles of different SIRTs in metabolic disorders and inflammation underscore the potential of SIRTs as viable pharmacological and therapeutic targets. Future research should focus on the development of promising compounds that target SIRTs, with the aim of enhancing their anti-inflammatory activity by influencing metabolic pathways within inflammatory cells.

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From fasting to fat reshaping: exploring the molecular pathways of intermittent fasting-induced adipose tissue remodeling

Vo,

Zhang,

Sung

2024

J. pharm. pharm. sci.

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Obesity, characterised by excessive fat accumulation, is a complex chronic condition that results from dysfunctional adipose tissue expansion due to prolonged calorie surplus. This leads to rapid adipocyte enlargement that exceeds the support capacity of the surrounding neurovascular network, resulting in increased hypoxia, inflammation, and insulin resistance. Intermittent fasting (IF), a dietary regimen that cycles between periods of fasting and eating, has emerged as an effective strategy to combat obesity and improve metabolic homeostasis by promoting healthy adipose tissue remodeling. However, the precise molecular and cellular mechanisms behind the metabolic improvements and remodeling of white adipose tissue (WAT) driven by IF remain elusive. This review aims to summarise and discuss the relationship between IF and adipose tissue remodeling and explore the potential mechanisms through which IF induces alterations in WAT. This includes several key structural changes, including angiogenesis and sympathetic innervation of WAT. We will also discuss the involvement of key signalling pathways, such as PI3K, SIRT, mTOR, and AMPK, which potentially play a crucial role in IF-mediated metabolic adaptations.

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The Emerging Role of SIRT7 in Glucose and Lipid Metabolism

Cited by 4 publications

References 131 publications

Role of miR-125b-5p in Modulating Placental SIRT7 Expression and Its Implications for Lipid Metabolism in Gestational Diabetes

Role of miR-125b-5p in Modulating Placental SIRT7 Expression and Its Implications for Lipid Metabolism in Gestational Diabetes

Metabolic mechanisms orchestrated by Sirtuin family to modulate inflammatory responses

From fasting to fat reshaping: exploring the molecular pathways of intermittent fasting-induced adipose tissue remodeling

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