The emerging role of the long non-coding RNA HOTAIR in breast cancer development and treatment

Mozdarani, Hossein; Ezzatizadeh, Vahid; Parvaneh, Roghayeh Rahbar

doi:10.1186/s12967-020-02320-0

Cited by 84 publications

(55 citation statements)

References 119 publications

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“…HOTAIR is considered to be a significant diagnostic marker for many neoplasms, including breast cancer, cervical cancer, or colorectal cancer. 87 , 88 , 89 Moreover, HOTAIR is considered to be one of the first tumor-related lncRNAs to have been discovered. It is associated with metastasis development and poor patient prognoses.…”

Section: Main Textmentioning

confidence: 99%

Small and Long Non-coding RNAs as Functional Regulators of Bone Homeostasis, Acting Alone or Cooperatively

Sikora

Marycz

Śmieszek

2020

Molecular Therapy - Nucleic Acids

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Emerging knowledge indicates that non-coding RNAs, including microRNAs (miRNAs) and long-noncoding RNAs (lncRNAs), have a pivotal role in bone development and the pathogenesis of bone-related disorders. Most recently, miRNAs have started to be regarded as potential biomarkers or targets for various sets of diseases, while lncRNAs have gained attention as a new layer of gene expression control acting through versatile interactions, also with miRNAs. The rapid development of RNA sequencing techniques based on next-generation sequencing (NGS) gives us better insight into molecular pathways regulated by the miRNA-lncRNA network. In this review, we summarize the current knowledge related to the function of miRNAs and lncRNAs as regulators of genes that are crucial for proper bone metabolism and homeostasis. We have characterized important non-coding RNAs and their expression signatures, in relationship to bone. Analysis of the biological function of miRNAs and lncRNAs, as well as their network, will pave the way for a better understanding of the pathogenesis of various bone disorders. We also think that this knowledge may lead to the development of innovative diagnostic tools and therapeutic approaches for bone-related disorders.

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Section: Main Textmentioning

confidence: 99%

Small and Long Non-coding RNAs as Functional Regulators of Bone Homeostasis, Acting Alone or Cooperatively

Sikora

Marycz

Śmieszek

2020

Molecular Therapy - Nucleic Acids

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“…HOTAIR was proposed to function as a scaffold to facilitate the recruitment of PRC2 and LSD1/CoREST/REST epigenetic complexes to increase H3K27me3 and H3K4me2, respectively, on targeted genomic loci [216][217][218]. Since p21 expression is regulated by PRC2 in lung cancer cells, it is possible that the upregulation of HOTAIR can promote the recruitment of PRC2 to downregulate p21 expression in lung adenocarcinoma cells [219,220]. However, the artificial chromatin tethering of HOTAIR in breast cancer cells caused transcription repression independently of PRC2 [221].…”

Section: Lncrnas In Solid Tumorsmentioning

confidence: 99%

Non-Coding RNAs as Mediators of Epigenetic Changes in Malignancies

Kumar

Gonzalez

Rameshwar

et al. 2020

Cancers

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Non-coding RNAs (ncRNAs) are untranslated RNA molecules that regulate gene expressions. NcRNAs include small nuclear RNAs (snRNAs), small nucleolar RNAs (snoRNAs), ribosomal RNAs (rRNAs), transfer RNAs (tRNAs), circular RNAs (cRNAs) and piwi-interacting RNAs (piRNAs). This review focuses on two types of ncRNAs: microRNAs (miRNAs) or short interfering RNAs (siRNAs) and long non-coding RNAs (lncRNAs). We highlight the mechanisms by which miRNAs and lncRNAs impact the epigenome in the context of cancer. Both miRNAs and lncRNAs have the ability to interact with numerous epigenetic modifiers and transcription factors to influence gene expression. The aberrant expression of these ncRNAs is associated with the development and progression of tumors. The primary reason for their deregulated expression can be attributed to epigenetic alterations. Epigenetic alterations can cause the misregulation of ncRNAs. The experimental evidence indicated that most abnormally expressed ncRNAs impact cellular proliferation and apoptotic pathways, and such changes are cancer-dependent. In vitro and in vivo experiments show that, depending on the cancer type, either the upregulation or downregulation of ncRNAs can prevent the proliferation and progression of cancer. Therefore, a better understanding on how ncRNAs impact tumorigenesis could serve to develop new therapeutic treatments. Here, we review the involvement of ncRNAs in cancer epigenetics and highlight their use in clinical therapy.

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“…Moreover, estradiol can bind with the estrogen response element in the promoter region of this lncRNA. Notably, HOTAIR activity has a crucial role in the induction of ER signaling in malignant cells [37]. Another study in prostate cancer cells revealed opposite functions of metastasis associated lung adenocarcinoma transcript 1 (MALAT1) and HOTAIR in estrogen-associated transcriptional modulation.…”

Section: Lncrnas and Er Functions In Cancersmentioning

confidence: 99%

Perspectives on the Role of Non-Coding RNAs in the Regulation of Expression and Function of the Estrogen Receptor

Taheri

Shoorei

Dinger

et al. 2020

Cancers

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Estrogen receptors (ERs) comprise several nuclear and membrane-bound receptors with different tissue-specific functions. ERα and ERβ are two nuclear members of this family, whereas G protein-coupled estrogen receptor (GPER), ER-X, and Gq-coupled membrane estrogen receptor (Gq-mER) are membrane-bound G protein-coupled proteins. ERα participates in the development and function of several body organs such as the reproductive system, brain, heart and musculoskeletal systems. ERβ has a highly tissue-specific expression pattern, particularly in the female reproductive system, and exerts tumor-suppressive roles in some tissues. Recent studies have revealed functional links between both nuclear and membrane-bound ERs and non-coding RNAs. Several oncogenic lncRNAs and miRNAs have been shown to exert their effects through the modulation of the expression of ERs. Moreover, treatment with estradiol has been shown to alter the malignant behavior of cancer cells through functional axes composed of non-coding RNAs and ERs. The interaction between ERs and non-coding RNAs has functional relevance in several human pathologies associated with estrogen regulation, such as cancers, intervertebral disc degeneration, coronary heart disease and diabetes. In the current review, we summarize scientific literature on the role of miRNAs and lncRNAs on ER-associated signaling and related disorders.

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The emerging role of the long non-coding RNA HOTAIR in breast cancer development and treatment

Cited by 84 publications

References 119 publications

Small and Long Non-coding RNAs as Functional Regulators of Bone Homeostasis, Acting Alone or Cooperatively

Small and Long Non-coding RNAs as Functional Regulators of Bone Homeostasis, Acting Alone or Cooperatively

Non-Coding RNAs as Mediators of Epigenetic Changes in Malignancies

Perspectives on the Role of Non-Coding RNAs in the Regulation of Expression and Function of the Estrogen Receptor

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