The emerging role of the gut microbiome in polycystic ovary syndrome

Abstract

Polycystic ovary syndrome (PCOS) is a widespread endocrine disorder that affects women of reproductive age. Recent studies have demonstrated a close association between the gut microbiome and PCOS. Their microbial diversity may not significantly change, and the crucial role of Bacteroides spp. has been demonstrated in human PCOS. Furthermore, animal models of PCOS exhibit gut microbiome features different from those of humans with PCOS. The gut microbiome may differ in patients with PCOS because it can be affected by multiple PCOS-related factors. Dysbiosis of the gut microbiome may trigger PCOS symptoms via an underlying mechanism that may involve microbial metabolites, including bile acids, short-chain fatty acids, and lipopolysaccharides. The manipulation of the gut microbiome can affect PCOS phenotypes, and prebiotic or probiotic therapy has the potential to improve PCOS symptoms. Future mechanistic studies are required to identify the causative role of these microbes and their metabolites in the pathogenesis of PCOS.

Rejoint of Carbon Nitride Fragments into Multi‐Interfacial Order‐Disorder Homojunction for Robust Photo‐Driven Generation of H2O2

“…This change can be attributed to the bubble template process, which introduces disorder and porosity into the material structure, thereby disrupting the π‐conjugated system. [ 39 ] On the other hand, the decreased bandgap observed in CN‐NaK and CN‐NH 4 ‐NaK can be attributed to the extension of the π‐conjugated system, indirectly indicating a decrease in the number of terminal amino groups. [ 38 ]…”

“…This change can be attributed to the bubble template process, which introduces disorder and porosity into the material structure, thereby disrupting the 𝜋-conjugated system. [39] On the other hand, the decreased bandgap observed in CN-NaK and CN-NH 4 -NaK can be attributed to the extension of the 𝜋-conjugated system, indirectly indicating a decrease in the number of terminal amino groups. [38] VB-XPS spectra was used to estimate the valence band (E VB, XPS ) of the prepared samples, as detailed in Figure S3 It is reported that the flat band potential of an n-type semiconductor equals its conduction band potential (E CB ).…”

Advances and Regulation Strategies of the Active Moiety in Dual‐Atom Site Catalysts for Efficient Electrocatalysis

“…anchored Fe 2 dimers on several carbon nanosheets to highlight the significance of electronic metal‐support interaction on the NRR performance with the assist of spin‐polarized DFT. [ 212 ] To be specific, these 2D carbon supports include defective graphene with pristine (C‐DV/G) or porphyrin‐like divacancy (N‐DV/G), graphdyine (GDY), and graphic carbide nitride (g‐C 3 N 4 ). The analyses indicate that the Fe 2 dimer can be firmly attached at the defect sites of these carbon substrates, resulting in the polarized positive charges accumulation at the Fe dimer center, accelerating the adsorption and activation process of the inert N 2 molecule.…”

Lactiplantibacillus plantarumCCFM1019 attenuate polycystic ovary syndrome through butyrate dependent gut–brain mechanism

“…5 With the rapid development of sequencing technology, changes in gut microbes have been confirmed in PCOS patients and in animal models of PCOS. 6 In addition, the manipulation of gut microbes, such as by faecal microbiota transplantation and cohousing of mice, affects PCOS phenotypes. 7,8 These findings indicate that treatments targeting the gut microbiota may be promising therapeutic strategies for PCOS.…”