The Emerging Roles and Therapeutic Potential of Extracellular Vesicles in Infertility

Zhou, Guannan; Gu, Yuanyuan; Zhou, Fang; Zhang, Menglei; Zhang, Ganrong; Wu, Ligang; Hua, Keqin; Ding, Jingxin

doi:10.3389/fendo.2021.758206

Cited by 13 publications

(4 citation statements)

References 77 publications

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“…Polycystic ovary syndrome (PCOS) (1,2) is widely defined as a kind of endocrine and metabolic disorder with a combination of signs and symptoms of androgen excess (hirsutism and/or hyperandrogenemia) and ovarian dysfunction (oligo-ovulation and/or polycystic ovarian morphology (PCOM)) (3). It was reported that the prevalence of PCOS in premenopausal women is up to almost 20% as the current, more inclusive definitions (4)(5)(6), which suggesting PCOS the most common endocrine and metabolic disorder in women at reproductive age.…”

Section: Introductionmentioning

confidence: 99%

Gut and Vaginal Microbiomes in PCOS: Implications for Women’s Health

Zhou

et al. 2022

Front. Endocrinol.

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PCOS is defined as a kind of endocrine and metabolic disorder which affects females at reproductive ages, is becoming much more common, nowadays. Microbiomes are known as microorganisms that inhabit the body to play a vital role in human health. In recent years, several basic and clinical studies have tried to investigate the correlation between the reproductive health/disorder and microbiomes (gut microbiomes and vaginal microbiomes). However, the mechanism is still unclear. In this review, we reviewed the relationship between PCOS and microbiomes, including gut/vaginal microbiomes compositions in PCOS, mechanism of microbiomes and PCOS, and then collectively focused on the recent findings on the influence of microbiomes on the novel insight regarding the therapeutic strategies for PCOS in the future clinical practice.

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Section: Introductionmentioning

confidence: 99%

Gut and Vaginal Microbiomes in PCOS: Implications for Women’s Health

Zhou

et al. 2022

Front. Endocrinol.

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“…Extracellular vesicles (EVs) are particles derived from diverse types of cells [15], containing diverse cargos [16,17]. EVs could play roles in the cell communications and complicated interplay during the biological processes[18] and the pathological processes [19]. It was widely reported that extracellular vesicles could exert in cell proliferation [20], wound healing, drug resistance and so on.…”

Section: Introductionmentioning

confidence: 99%

Ovarian cancer derived extracellular vesicles promote the metastasis and angiogenesis by mediating M2 macrophages polarization

Tang,

Ma,

et al. 2024

Preprint

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Background Extracellular vesicles involve in the interplay between the cancer cells and other cells (including tumor associated macrophages) surrounding the tumor microenvironment, to remodel the tumor microenvironment and subsequently regulate the tumor progression. However, the underlying molecular mechanism of these complicated crosstalk are still unclear. Methods Firstly, we explored the effect of tumor-associated macrophages (TAM) on the survival prognosis among patients with ovarian cancer. Then we isolated the extracellular vesicles derived from ovarian cancer cells (OV-EVs) through ultra-centrifugation, and then analyzed the effect of OV-EVs on regulating macrophages polarization in ovarian tumor and in whole peripheral blood. Meanwhile, we explored the roles of the OV-EVs induced macrophages in tumor progression through in vitro assay and in vivo assays. Results OV-EVs could be encapsulated by the macrophages and could induce macrophages into M2 phenotype. Meanwhile, the OV-EVs induced-M2 macrophage could promote the angiogenesis as well as the cancer metastasis in vitro and in vivo. In addition, OV-EVs induced macrophage could stimulate the angiogenesis in vivo through increasing the expression level of VEGF and the expression level of VEGFR in tumor. Conclusions The present study demonstrated that OV-EVs could induce the macrophages into M2 polarization and promote the metastasis of ovarian cancer. The study provides a new insight to understand the mechanism in ovarian cancer progression.

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“…Infertility is a disease of the male or female reproductive system that results in failure to conceive after 12 months or longer of natural fertilization ( 10 ). According to estimates by the World Health Organization, about one in six couples of reproductive age worldwide may need assisted reproductive technology (ART) due to fertility problems ( 10 , 11 ). ART, including in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI), has been widely used among infertility patients ( 12 ).…”

Section: Introductionmentioning

confidence: 99%

Effect of BMI on cumulative live birth rates in patients that completed IVF treatment: a retrospective cohort study of 16,126 patients

Zheng,

Zhang,

et al. 2024

Endocrine Connections

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Although several studies have reported that high maternal BMI could influence the cumulative live birth rate (CLBR) in fresh embryo transfer cycles, the association of BMI with CLBR remains unclear in patients treated with complete IVF. In this study, we examined the association of maternal BMI with CLBR, including repetitive one oocyte pick-up (OPU) and all fresh and frozen embryo transfer until live birth or embryos were run out. A total of 16,126 patients’ data were included in the analysis and were divided into four groups based on BMI. We found that patients' characteristics, embryo parameters, and pregnancy outcomes differed among different BMI groups. Multivariate logistic regression showed that being underweight was associated with a higher possibility of having live birth than the reference group [OR (95% CI), 1.40 (1.22-1.59), p<0.001], whereas being overweight and obese were associated with a lower possibility of having live birth than the reference group ([OR (95% CI), 0.81 (0.74-0.90), p<0.001] and [OR (95% CI), 0.68 (0.55-0.85), p<0.001]). After adjustment for confounding factors, the reference group was associated with a higher possibility of having live birth, with a significant difference found between the obese and reference groups [OR (95% CI), 0.55 (0.43-0.70), p<0.001]. An association was found between CLBR and BMI, indicating that an increase in BMI results in a decline in CLBR. Moreover, the CLBR of patients with different characteristics differed in the various BMI groups. Taken together, our data show that maternal BMI has a significant impact on CLBR.

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The Emerging Roles and Therapeutic Potential of Extracellular Vesicles in Infertility

Cited by 13 publications

References 77 publications

Gut and Vaginal Microbiomes in PCOS: Implications for Women’s Health

Gut and Vaginal Microbiomes in PCOS: Implications for Women’s Health

Ovarian cancer derived extracellular vesicles promote the metastasis and angiogenesis by mediating M2 macrophages polarization

Effect of BMI on cumulative live birth rates in patients that completed IVF treatment: a retrospective cohort study of 16,126 patients

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