The Emerging Roles of CCN3 Protein in Immune-Related Diseases

Peng, Lei; Wei, Yingying; Shao, Yijia; Li, Yang; Liu, Na; Duan, Lihua

doi:10.1155/2021/5576059

Cited by 15 publications

(16 citation statements)

References 74 publications

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“…In the current study, at p = 0.0001, CCN3 concentrations in the serum of patients were discovered to be significantly greater than in the serum of controls. Wang et al, (2021), found that the amount of CCN3 in patients was greater than in controls (p 0.0001), which proved this result, Also, Peng et al, (2021) found that CCN3 was highly expressed in RA synovial samples when compared with normal joint tissues.…”

Section: Discussionmentioning

confidence: 62%

“…One of the CCN family members, CCN3 is also known as nephroblastoma overexpressed protein (NOV), and it has been linked to a number of important cellular activities, including the expansion of cells, migration, and differentiation. In the last several years, CCN3 has emerged as an important regulator in a wide range of disorders, including rheumatic arthritis, systemic sclerosis , and osteoarthritis (Peng et al, 2021a). CCN3 preserves the whole CCN family's prototypical structure.…”

Section: Introductionmentioning

confidence: 99%

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Association Of Cellular Communication Network Factor 3 (CCN3) With Rheumatoid Arthritis Disease And It's Severity (Case-Control Study)

Zayed

2022

Med.Sci.Jour.Adv.Res

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Background: An inflammatory condition that affects the joints in the limbs is rheumatoid arthritis. The most common symptom is chronic, recurrent joint inflammation. When patients are advanced, joint deformities and impairments may cause major impediments in the cardiac, skin, as well as other tissues and organs. A protein called cellular CCN3 is implicated in many biological processes such as cell adhesion, migration, as well as proliferation. Additionally, CCN3 has a role in a number of pathological processes, such as fibrosis, angiogenesis, and wound healing. CCN3 can be released from the cytoplasm. CCN3 may also be an inflammatory component in the course of RA. Future therapy approaches that focus on the activities and mechanisms of action of these proteins may result from better knowledge of how CCN proteins alter the pathophysiological processes underlying these types of arthritis and successfully reduce patients' pain (Wei et al., 2020). It was discovered that RA sera and tissues had increased levels of all CCN family members. IL6 production and CCN3 expression are correlated with disease activity (Giusti & Scotlandi, 2021). Methods: Between November 2021 and April 2022, a study including 70 patients with RA who met four or more 2010 American College of Rheumatology and European League Against Rheumatism (ACR/EULAR) classification criteria for the condition and 70 healthy persons serving as control groups was conducted. All subjects had their disease activity score (DAS28-ESR), clinical activity index (CDAI), and rheumatoid factors (RF) detected by latex agglutination. By using an enzyme-linked immunosorbent assay, the levels of anti-cyclic citrullinated peptide (ACCP) and CCN3 in human serum samples were determined (ELISA).The age group of both the patients and the controls included in this study was 20-70. RA was found to be high in individuals of the age group >40 years, at a percentage of 71.4%. The mean age was 46.2±10.3 years for patients and 1.7±0.5 for controls.Results: The results clearly showed high serum CCN3 levels in patient groups with RA compared to control (P = 0.0001). CCN3 and ACCP have a significantly positive association at control (P = 0.0001). According to DAS28-ESR, there were significantly increased concentrations of CCN3 in severe patients at P values of 0.0001 in comparison to mild patients. Conclusions: The biomarker CCN3 is a good prognostic marker for the severity of RA.

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Section: Discussionmentioning

confidence: 62%

Section: Introductionmentioning

confidence: 99%

Association Of Cellular Communication Network Factor 3 (CCN3) With Rheumatoid Arthritis Disease And It's Severity (Case-Control Study)

Zayed

2022

Med.Sci.Jour.Adv.Res

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“…The most significantly expressed genes in the epithelia were Claudins 4 and 7 ( Cldn4 and Cldn7 ), two integral membrane proteins that determine tight junction permeability [ 42 ]. In the endometrial stroma, the most significantly expressed gene was Ccn3 , an extracellular matrix protein which regulates growth and differentiation [ 43 ]. In the endometrial macrophages, the most significantly expressed genes were C1qa and C1qc , components of the C1q complex of the complement system which can also act as a tumor-promoting factor [ 44 ].…”

Section: Resultsmentioning

confidence: 99%

Obesity alters the mouse endometrial transcriptome in a cell context-dependent manner

Wilson

Skalski

Reske

et al. 2022

Reprod Biol Endocrinol

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Obesity impacts fertility and is positively correlated with endometrial hyperplasia and endometrial cancer occurrence. Endometrial epithelia often harbor disease driver-mutations, while endometrial stroma are highly regulative of neighboring epithelia. Here, we sought to determine distinct transcriptome changes occurring in individual cell types in the obese mouse uterus. Outbred CD-1 mice were fed high-fat or control diets for 18 weeks, estrous cycle staged, and endometrial epithelia, macrophages, and stroma isolated for transcriptomic analysis. High-fat diet mice displayed increased body mass and developed glucose intolerance, hyperinsulinemia, and fatty liver. Obese mouse epithelia displayed differential gene expression for genes related to innate immunity and leukocyte chemotaxis. The obese mouse stroma differentially expressed factors related to circadian rhythm, and expression of these genes correlated with glucose tolerance or body mass. We observed correlations between F4/80 + macrophage numbers, Cleaved Caspase 3 (CC3) apoptosis marker staining and glucose intolerance among obese mice, including a subgroup of obese mice with high CC3 + luminal epithelia. This subgroup displayed differential gene expression among all cell types, with pathways related to immune escape in epithelia and macrophages, while the stroma dysregulated pathways related to regulation of epithelia. These results suggest an important role for differential response of both the epithelia and stroma in their response to obesity, while macrophages are dysregulated in the context of apoptotic epithelia. The obesity-related gene expression programs in cells within the uterine microenvironment may influence the ability of the endometrium to function during pregnancy and influence disease pathogenesis.

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“…Our study indicated that the immune-related genes CCN3 , HAS2 , and RICTOR were upregulated in the B. fragilis group . CCN3 participates in the functional regulation of regulatory T cells (Tregs) and hematopoietic stem cells; it can regulate angiogenesis and promote endothelial cell adhesion and survival ( Lin et al, 2003 ; Peng et al, 2021 ). Studies have shown that CCN3 loss leads to a significant increase in lipid uptake and foam cell formation in macrophages, while overexpression can inhibit atherosclerosis ( Shi et al, 2017 ).…”

Section: Discussionmentioning

confidence: 99%

Multi-Omics Analysis After Vaginal Administration of Bacteroides fragilis in Chickens

Yang

Zhu

et al. 2022

Front. Microbiol.

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The reproductive tract of chickens is an important organ for egg formation. The vagina is in close contact with the external environment, which may lead to the invasion of a variety of pathogenic bacteria, affect the internal and external quality of eggs, and even increase mortality and cause economic loss. In recent years, probiotics as a substitute for antibiotics have brought economic benefits in livestock and poultry production. In the present study, we investigated the effects of vaginal administration of Bacteroides fragilis on the cloacal microbiota, vaginal transcriptome and metabolomics of chickens and evaluated the beneficial potential of B. fragilis. The results showed that B. fragilis treatment could affect the microbial composition of the cloaca. Transcriptome analysis found that the immune-related genes CCN3, HAS2, and RICTOR were upregulated, that the inflammatory genes EDNRB, TOX, and NKX2-3 were downregulated, and that DEGs were also enriched in the regulation of the inflammatory response, cellular metabolism, and synaptic response pathways. In addition, the differential metabolites were mainly related to steroid hormone biosynthesis, unsaturated fatty acid biosynthesis, and arachidonic acid metabolism, and we identified associations between specific differential metabolites and genes. Overall, this study provides a theoretical basis for the application of B. fragilis as a potential probiotic in livestock and poultry production.

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The Emerging Roles of CCN3 Protein in Immune-Related Diseases

Cited by 15 publications

References 74 publications

Association Of Cellular Communication Network Factor 3 (CCN3) With Rheumatoid Arthritis Disease And It's Severity (Case-Control Study)

Association Of Cellular Communication Network Factor 3 (CCN3) With Rheumatoid Arthritis Disease And It's Severity (Case-Control Study)

Obesity alters the mouse endometrial transcriptome in a cell context-dependent manner

Multi-Omics Analysis After Vaginal Administration of Bacteroides fragilis in Chickens

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