The emerging roles of exosomes in autoimmune diseases, with special emphasis on microRNAs in exosomes

Miao, Chenggui; Wang, Xiao; Zhou, Wanwan; Huang, Jinling

doi:10.1016/j.phrs.2021.105680

Cited by 46 publications

(30 citation statements)

References 92 publications

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“…When LN is in the active stage of the disease, the contents of let-7a and miR-21 in the exosome are significantly reduced and negatively correlated with glomerular filtration rate and protein leakage, but their contents gradually increase during concomitant treatment. This can serve as diagnostic criteria for the clinical staging of LN patients [66] , [67] . miR-654-5p and miR-3135b may serve as noninvasive diagnostic markers for crescent-shaped LNIV [68] .…”

Section: Diagnostic Role Of Mirnas In Exosomes For Slementioning

confidence: 99%

Progress of exosome research in systemic lupus erythematosus

2022

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Section: Diagnostic Role Of Mirnas In Exosomes For Slementioning

confidence: 99%

Progress of exosome research in systemic lupus erythematosus

2022

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“…It was shown that when piglets were fed pig or cow’s milk, miRNAs could be absorbed both in vivo and in vitro , which creates the basis for understanding the participation of miRNAs in physiological functions ( Lin et al, 2020 ). miRNAs are key effectors in physiology and development of infants ( Wang L. et al, 2021 ; Zhou Q. et al, 2021 ; Leroux et al, 2021 ; Miao et al, 2021 ; Shah et al 2021 ). In earlier works, it was shown that ex-miRs from food are bioactive, and both humans and animals can absorb miRNAs from a diet of plant or animal source ( Zhang L. et al, 2012 ; Wang et al, 2012 ; Baier et al, 2014 ; Zhou et al, 2015 ).…”

Section: Introductionmentioning

confidence: 99%

Identification of Bovine miRNAs with the Potential to Affect Human Gene Expression

et al. 2022

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Milk and other products from large mammals have emerged during human evolution as an important source of nutrition. Recently, it has been recognized that exogenous miRNAs (mRNA inhibited RNA) contained in milk and other tissues of the mammalian body can enter the human body, which in turn have the ability to potentially regulate human metabolism by affecting gene expression. We studied for exogenous miRNAs from Bos taurus that are potentially contain miRNAs from milk and that could act postprandially as regulators of human gene expression. The interaction of 17,508 human genes with 1025 bta-miRNAs, including 245 raw milk miRNAs was studied. The milk bta-miR-151-5p, bta-miR-151-3p, bta-miRNA-320 each have 11 BSs (binding sites), and bta-miRNA-345-5p, bta-miRNA-614, bta-miRNA-1296b and bta-miRNA-149 has 12, 14, 15 and 26 BSs, respectively. The bta-miR-574-5p from cow’s milk had 209 human genes in mRNAs from one to 25 repeating BSs. We found 15 bta-miRNAs that have 100% complementarity to the mRNA of 13 human target genes. Another 12 miRNAs have BSs in the mRNA of 19 human genes with 98% complementarity. The bta-miR-11975, bta-miR-11976, and bta-miR-2885 BSs are located with the overlap of nucleotide sequences in the mRNA of human genes. Nucleotide sequences of BSs of these miRNAs in 5′UTR mRNA of human genes consisted of GCC repeats with a total length of 18 nucleotides (nt) in 18 genes, 21 nt in 11 genes, 24 nt in 14 genes, and 27–48 nt in nine genes. Nucleotide sequences of BSs of bta-miR-11975, bta-miR-11976, and bta-miR-2885 in CDS mRNA of human genes consisted of GCC repeats with a total length of 18 nt in 33 genes, 21 nt in 13 genes, 24 nt in nine genes, and 27–36 nt in 11 genes. These BSs encoded polyA or polyP peptides. In only one case, the polyR (SLC24A3 gene) was encoded. The possibility of regulating the expression of human genes by exogenous bovine miRNAs is discussed.

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“…For example, when the body produces abnormal immune responses to bacteria, viruses, or food particles, it triggers an intestinal inflammatory response and IBD [3]. Studies have shown that the intestinal microbiota is involved in the Pharmaceutics 2021, 13, 1644 2 of 20 treatment of IBD. For example, transplantation of fecal microbiota from healthy controls into the intestines of IBD patients has been used clinically as an emerging treatment for IBD [4].…”

Section: Introductionmentioning

confidence: 99%

“…Many cell types can secrete exosomes under normal and pathological conditions. Exosomes mainly come from the multivesicle formed by the invagination of lysosomal particles in cells, which are released into the extracellular matrix after fusion between the multivesicle outer membrane and the cell membrane [13].…”

Section: Introductionmentioning

confidence: 99%

Exosomes as a New Delivery Vehicle in Inflammatory Bowel Disease

Wang

Zhou

et al. 2021

Pharmaceutics

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Inflammatory bowel disease (IBD) is a type of chronic relapsing inflammatory disease. The pathogenesis of IBD is still unclear, which may involve environmental factors, genetic factors, intestinal microbiota disorder, and abnormal immune responses. Exosomes (30–150 nm) are found in various body fluids, including blood, saliva, urine, and cerebrospinal fluid. Exosomes mediate intercellular communication and regulate cell biological activity by carrying non-coding RNAs, proteins, and lipids. There is evidence that exosomes are involved in the pathogenesis of IBD. In view of the important roles of exosomes in the pathogenesis of IBD, this work systematically reviews the latest research progress of exosomes in IBD, especially the roles of exosomes as non-coding RNA delivery systems in the pathogenesis of IBD, including a disordered immune response, barrier function, and intestinal microbiota. The review will help to clarify the pathogenesis of IBD and explore new diagnostic markers and therapeutic targets for patients with IBD.

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The emerging roles of exosomes in autoimmune diseases, with special emphasis on microRNAs in exosomes

Cited by 46 publications

References 92 publications

Progress of exosome research in systemic lupus erythematosus

Progress of exosome research in systemic lupus erythematosus

Identification of Bovine miRNAs with the Potential to Affect Human Gene Expression

Exosomes as a New Delivery Vehicle in Inflammatory Bowel Disease

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