The emerging tick-borne Crimean-Congo haemorrhagic fever virus: A narrative review

Serretiello, Enrica; Astorri, Roberta; Chianese, Annalisa; Stelitano, Debora; Zannella, Carla; Folliero, Veronica; Santella, Biagio; Galdiero, Massimiliano; Franci, Gianluigi; Galdiero, Massimiliano

doi:10.1016/j.tmaid.2020.101871

Cited by 33 publications

(47 citation statements)

References 197 publications

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“…da Silva et al [180] confirmed the dissemination of SFTS virus to na€ ıve cells via exosomes, and this is also known to confer protection from neutralizing antibodies deciphering viral replication. MVBs release the Crimean-Congo hemorrhagic fever virus through the ESCRT pathway, as demonstrated by suppressing the virus via silencing the regulators of ESCRT-based biogenesis with inhibitors [5]. Therefore, it is important to identify and characterize the proteins enclosed within the tick exosomes to design effective anti-tick vaccines [99].…”

Section: Role Of Tick Smases In Exosome Biogenesismentioning

confidence: 99%

“…Tick-borne diseases such as Lyme borreliosis, human anaplasmosis, spotted fevers, ehrlichiosis, hemorrhagic fevers, tick-borne encephalitis and babesiosis are of serious public health concern [1][2][3]. Also, emerging tick-borne viruses of the Bunyaviridae family have gained attention because of the threats that they pose to public health, such as severe fever with thrombocytopenia syndrome virus, Crimean-Congo hemorrhagic fever and heartland virus [4,5]. Tick bite-mediated paralysis and toxicosis are also recorded in animals [6,7].…”

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confidence: 99%

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Sphingomyelinases in a journey to combat arthropod‐borne pathogen transmission

2021

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Ixodes scapularis ticks feed on humans and other vertebrate hosts and transmit several pathogens of public health concern. Tick saliva is a complex mixture of bioactive proteins, lipids and immunomodulators, such as I. scapularis sphingomyelinase (IsSMase)-like protein, an ortholog of dermonecrotoxin SMase D found in the venom of Loxosceles spp. of spiders. IsSMase modulates the host immune response towards Th2, which suppresses Th1-mediated cytokines to facilitate pathogen transmission. Arboviruses utilize exosomes for their transmission from tick to the vertebrate host, and exosomes derived from tick saliva/salivary glands suppress C-X-C motif chemokine ligand 12 and interleukin-8 immune response(s) in human skin to delay wound healing and repair processes. IsSMase affects also viral replication and exosome biogenesis, thereby inhibiting tick-to-vertebrate host transmission of pathogenic exosomes. In this review, we elaborate on exosomes and their biogenesis as potential candidates for developing novel control measure(s) to combat tickborne diseases. Such targets could help with the development of an efficient anti-tick vaccine for preventing the transmission of tick-borne pathogens.

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Section: Role Of Tick Smases In Exosome Biogenesismentioning

confidence: 99%

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confidence: 99%

Sphingomyelinases in a journey to combat arthropod‐borne pathogen transmission

2021

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“…Tick-borne diseases, including tick-borne encephalitis, Lyme disease, anaplasmosis and Crimean-Congo hemorrhagic fever, have emerged as a global public concern since the beginning of the century (Dantas-Torres et al 2012;Dantas-Torres 2015). In parallel to progress made in the fields of diagnostic and therapeutic technologies (Bologheanu et al 2020;Serretiello et al 2020) and in vaccine design (De la Fuente et al 2017), mathematical models and analyses have also been advanced, using differential equations to explore the long-term behaviors of tick-borne pathogen spread in the vector-host interaction (see Wu et al 2013;Rosà and Pugliese 2007;Zhang and Wu 2020 and references therein).…”

Section: Introductionmentioning

confidence: 99%

Synchronized Tick Population Oscillations Driven by Host Mobility and Spatially Heterogeneous Developmental Delays Combined

Zhang

2021

Bull Math Biol

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We consider a coupled system of delay differential equations for a single-species tick population dynamics, assuming feeding adult ticks are distributed by their hosts in a spatially heterogeneous environment consisting of two patches where egg ticks produced will complete their life cycles with different, normal and diapause, developmental delays. We show that the mobility of adult tick host and the diapause developmental delay combined drive a synchronized oscillation in the total tick populations around a uniquely defined positive equilibrium, and this synchronization makes the oscillatory patterns much simpler in comparison with multi-peak oscillations exhibited in the absence of host mobility.

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“…In severe cases, there are signs of bleeding and multiple organ dysfunction (Bente et al, 2013; Ergönül, 2006). Ticks (mainly from the genus Hyalomma ) are the main vectors of CCHFV; they are not only carriers of the virus, but they are also the natural reservoir of the virus (Spengler et al, 2019; Serretiello et al, 2020). There are no obvious symptoms in mammals infected with CCHFV (Negredo et al, 2019; Spengler et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

“…Meanwhile, birds are resistant to CCHFV infection (Negredo et al, 2019). Although some infected animals are usually without infection symptoms, they can still act as hosts in pathogen transmission routes (Serretiello et al, 2020; Spengler et al, 2016; Sorvillo et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Phylogenetic Analysis of Crimean-Congo Hemorrhagic Fever Virus in Inner Mongolia, China

Kong

Yan

Liu

et al. 2021

Preprint

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Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne arbovirus that can cause bleeding and death in humans. The mortality rate in humans is between 5 to 30%. The pathogen is prevalent in more than 30 countries in the world. In China, reports of strains of CCHFV have been concentrated in Xinjiang province. However, the CCHFV strain has never been reported in Inner Mongolia, China. This study reports new CCHFV strains, HANM-18, from Hyalomma asiaticum and Hyalomma dromedarii collected in Alxa Left Banner and Alxa Right Banner in Inner Mongolia. Complete sequences of CCHFV were obtained by the nested PCR technique and used for analyzing the identity and evolutionary relationship with other CCHFV strains. Interestingly, our results showed that the S and L fragments of the HANM-18 strain had high degrees of identity with Xingjiang isolate strains, and the M fragment had significant identity with South African isolates. These analyses also indicate that the HANM-18 strain may have been prevalent in northwest Inner Mongolia for many years. This discovery will be helpful in CCHF prevention and control in Inner Mongolia, and it also adds new evidence to the epidemiology of CCHF in China.

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The emerging tick-borne Crimean-Congo haemorrhagic fever virus: A narrative review

Cited by 33 publications

References 197 publications

Sphingomyelinases in a journey to combat arthropod‐borne pathogen transmission

Sphingomyelinases in a journey to combat arthropod‐borne pathogen transmission

Synchronized Tick Population Oscillations Driven by Host Mobility and Spatially Heterogeneous Developmental Delays Combined

Phylogenetic Analysis of Crimean-Congo Hemorrhagic Fever Virus in Inner Mongolia, China

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