The emerging trends of falciparum malaria: a study from a tertiary centre in an endemic area of India

Poovathingal, Mary Anne; Nagiri, Shivashankara Kaniyoor; Nagaraja,

doi:10.12980/apjtb.4.2014c1139

Cited by 1 publication

(3 citation statements)

References 11 publications

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“…One case-control study [72] was conducted in adults on the clinical and lab profile of dengue and scrub typhus coinfection. Two cross-sectional studies [54, 60] were conducted on malaria in adults while one was conducted on leptospirosis in adults [53]. Fifteen studies were conducted on scrub typhus.…”

Section: Resultsmentioning

confidence: 99%

“…26 studies used malaria diagnostics [2, 16, 48, 50, 51, 53–55, 57, 60, 65, 68, 70, 71, 73, 74, 76–85] 14 studies (54%) used smear microscopy for parasite detection [2, 16, 48, 53, 54, 57, 73, 74, 76, 77, 79, 80, 84, 85]. and the remaining used RDT or quantitative buffy coat (QBC) alone or in combination for malaria diagnosis (Fig.…”

Section: Resultsmentioning

confidence: 99%

“…One case-control study had a high risk of bias [72]. Eight (30.8%) [2, 16, 49, 51, 55, 64, 69, 70], nine (34.6%) [53, 54, 56, 57, 59, 62, 65, 67, 68], five (19.2%) [48, 60, 61, 66, 71] and four (15.4%) [50, 52, 58, 63] studies out of 26 cross-sectional studies showed very low, low, moderate and high risk of bias, respectively (Additional file 1: Table S15).…”

Section: Resultsmentioning

confidence: 99%

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Diagnostic tools used in the evaluation of acute febrile illness in South India: a scoping review

Bhaskaran

Chadha²,

Sarin³

et al. 2019

BMC Infect Dis

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BackgroundAcute febrile illness (AFI) is characterized by malaise, myalgia and a raised temperature that is a nonspecific manifestation of infectious diseases in the tropics. The lack of appropriate diagnostics for the evaluation of AFI leads to increased morbidity and mortality in resource-limited settings, specifically low-income countries like India. The review aimed to identify the number, type and quality of diagnostics used for AFI evaluation during passive case detection at health care centres in South India.MethodsA scoping review of peer-reviewed English language original research articles published between 1946-July 2018 from four databases was undertaken to assess the type and number of diagnostics used in AFI evaluation in South India. Results were stratified according to types of pathogen-specific tests used in AFI management.ResultsThe review included a total of 40 studies, all conducted in tertiary care centres (80% in private settings). The studies demonstrated the use of 5–22 tests per patient for the evaluation of AFI. Among 25 studies evaluating possible causes of AFI, 96% tested for malaria followed by 80% for dengue, 72% for scrub typhus, 68% for typhoid and 60% for leptospirosis identifying these as commonly suspected causes of AFI. 54% studies diagnosed malaria with smear microscopy while others diagnosed dengue, scrub typhus, typhoid and leptospirosis using antibody or antigen detection assays. 39% studies used the Weil-Felix test (WFT) for scrub typhus diagnosis and 82% studies used the Widal test for diagnosing typhoid.ConclusionsThe review demonstrated the use of five or more pathogen-specific tests in evaluating AFI as well as described the widespread use of suboptimal tests like the WFT and Widal in fever evaluation. It identified the need for the development of better-quality tests for aetiological diagnosis and improved standardised testing guidelines for AFI.

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Section: Resultsmentioning

confidence: 99%