A 14-year-old boy was referred to the Department of Pedodontics and Preventive dentistry with complain of pain in right mandibular posterior teeth since three weeks. Careful intraoral examination revealed a sinus tract found on the buccal gingiva of the right lower second premolar. Hard tissue examination revealed the presence of a deep pit in right mandibular second premolar. Radiographic examination revealed deep pit communicating with the pulp space, presence of blunderbuss canal and the presence of large irregular radiolucency suggestive of chronic abscess with bone resorption associated with mandibular right premolar teeth [Table/ Fig-1]. The presence of sinus tract with periapical radiolucency indicative of chronic periapical abscess confirmed the necrosis of pulp. Nonsurgical endodontic treatment with apexification was considered keeping in view the age and amount of trauma expected during surgical treatment. Pulpal necrosis confirmed the non vitality of the tooth. Hence, the need of giving local anesthesia was excluded. The informed written consent was taken from the parents. Access opening was done under rubber dam isolation. Due to exudation of pus from the canal, the access cavity was left open. In next appointment the biomechanical preparation was done using circumferential filling till size 80K file. Sodium hypochlorite 1% solution was used as root canal irrigant throughout the procedure. In the same sitting calcium hydroxide and iodoform combination (Metapexô, META Biomed Co. Ltd., Korea) was placed in the canal which was accidentally extruded into the periapical lesion [Table/ Fig-2]. The patient was then recalled after two weeks. The healing of sinus and history of no pain was evident in the recall appointment.Patient was followed for 3, 6 & 12 months. During these appointments, the follow up radiograph revealed, metapex that had aBstRaCt The paper discusses a case of an immature premolar tooth with a large periapical lesion, in which Metapex (calcium hydroxide paste containing iodoform and barium sulphate as a radiopacifier) was used. There was an un-intentional extrusion of calcium hydroxide during application. The patient was evaluated for periapical healing at 12 and 24 months. The follow up revealed that the accidental extrusion of metapex did not have any detrimental effect on periapical healing. However, delayed resorption of Metapex as well as healing of the periapical lesion may be attributed to the presence of BaSO 4 and iodoform as compared to plain Calcium hydroxide. extruded in the periradicular region has not resorbed; in addition, the periapical lesion was seen to have decreased in size [Table/ Fig-3]. At the end of 12 months apical barrier was formed. A file was used that can easily reach the apex to gently probe for a stop at the apex. At that time, the medicament was removed from the canal using H-file followed by irrigation with 1.25% sodium hypochlorite. After confirming dryness of canal, the root canal was finally obturated after 12 months with Gutta-percha by using the cold ...