The endogenous mink cell focus-forming (MCF) gp70 linked to the Rmcf gene restricts MCF virus replication in vivo and provides partial resistance to erythroleukemia induced by Friend murine leukemia virus.

Buller, R S; Sitbon, Marc; Portis, John L.

doi:10.1084/jem.167.5.1535

Cited by 27 publications

(24 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies have indicated that some endogenous retroviruses may provide protection against homologous exogenous retroviral infection through receptor interference. Evidence of endogenous production of related envelope surface proteins could block receptors utilized by exogenous retroviruses, which has been documented for Friend murine leukemia virus and FeLV (9,(54)(55)(56)(57)(58)(59). Experiments conducted by McDougall et al demonstrated that infection of permissive fibroblasts with FeLV-B was prevented in cell culture medium containing an enFeLV-produced protein thought to be the envelope protein (58).…”

Section: Figmentioning

confidence: 99%

Feline Leukemia Virus (FeLV) Disease Outcomes in a Domestic Cat Breeding Colony: Relationship to Endogenous FeLV and Other Chronic Viral Infections

Powers

Chiu

Kraberger

et al. 2018

J Virol

View full text Add to dashboard Cite

Exogenous feline leukemia virus (FeLV) is a feline gammaretrovirus that results in a variety of disease outcomes. Endogenous FeLV (enFeLV) is a replication-defective provirus found in species belonging to the genus, which includes the domestic cat (). There have been few studies examining interaction between enFeLV genotype and FeLV progression. We examined point-in-time enFeLV and FeLV viral loads, as well as occurrence of FeLV/enFeLV recombinants (FeLV-B), to determine factors relating to clinical disease in a closed breeding colony of cats during a natural infection of FeLV. Coinfections with feline foamy virus (FFV), feline gammaherpesvirus 1 (FcaGHV-1), and feline coronavirus (FCoV) were also documented and analyzed for impact on cat health and FeLV disease. Correlation analysis and structural equation modeling techniques were used to measure interactions among disease parameters. Progressive FeLV disease and FeLV-B presence were associated with higher FeLV proviral and plasma viral loads. Female cats were more likely to have progressive disease and FeLV-B. Conversely, enFeLV copy number was higher in male cats and negatively associated with progressive FeLV disease. Males were more likely to have abortive FeLV disease. FFV proviral load was found to correlate positively with higher FeLV proviral and plasma viral load, detection of FeLV-B, and FCoV status. Male cats were much more likely to be infected with FcaGHV-1 than female cats. This analysis provides insights into the interplay between endogenous and exogenous FeLV during naturally occurring disease and reveals striking variation in the infection patterns among four chronic viral infections of domestic cats. Endogenous retroviruses are harbored by many animals, and their interactions with exogenous retroviral infections have not been widely studied. Feline leukemia virus (FeLV) is a relevant model system to examine this question, as endogenous and exogenous forms of the virus exist. In this analysis of a large domestic cat breeding colony naturally infected with FeLV, we documented that enFeLV copy number was higher in males and inversely related to FeLV viral load and associated with better FeLV disease outcomes. Females had lower enFeLV copy numbers and were more likely to have progressive FeLV disease and FeLV-B subtypes. FFV viral load was correlated with FeLV progression. FFV, FcaGHV-1, and FeLV displayed markedly different patterns of infection with respect to host demographics. This investigation revealed complex coinfection outcomes and viral ecology of chronic infections in a closed population.

show abstract

Section: Figmentioning

confidence: 99%

Feline Leukemia Virus (FeLV) Disease Outcomes in a Domestic Cat Breeding Colony: Relationship to Endogenous FeLV and Other Chronic Viral Infections

Powers

Chiu

Kraberger

et al. 2018

J Virol

View full text Add to dashboard Cite

show abstract

“…This locus appears to also mediate viral interference and restricts specifically infection by polytropic viruses. In genetic studies, we found that the Rmcf allele segregated with the 514-reactive gp70 of D2 mice (Buller et al 1987), and this protein also appeared to segregate with resistance to erythroleukemia (Buller et al 1988). Furthermore, the 18-6-reactive gp70 of C57BL mice appeared to function as a resistance gene for a brain disease caused by a neurovirulent polytropic virus (Buller et al 1990).…”

Section: Viral Specificities Of Gvhr Monoclonal Antibodiesmentioning

confidence: 99%

“…Furthermore, the 18-6-reactive gp70 of C57BL mice appeared to function as a resistance gene for a brain disease caused by a neurovirulent polytropic virus (Buller et al 1990). Expression of both the 514 and 18-6-reactive gp70 in vivo is associated with a restriction of replication and/or spread of recombinant polytropic viruses (Buller et al 1988;Buller et al 1990). Whether these two env genes are encoded by the Rmcf locus itself is not yet clear.…”

Section: Viral Specificities Of Gvhr Monoclonal Antibodiesmentioning

confidence: 99%

Endogenous Retroviral Envelope Antigens Recognized by B Lymphocytes during Graft-Versus-Host Reaction.

Portis¹

1994

Tohoku J. Exp. Med.

View full text Add to dashboard Cite

We recovered anti-murine retroviral hybridomas from the spleen cells of (B6 x D2) Fl mice in which graft-versus-host reaction (GVHR) had been induced by the infusion of spleen cells from either parent. The antibodies were specific for envelope proteins of endogenous retroviruses, and have provided a convenient way of classifying viruses based on their host range. They also have revealed considerable serologic heterogeneity within each host-range group. We have utilized these antibodies to characterize endogenous envelope glycoproteins in uninoculated mice. In this report I have attempted to synthesize the results of studies carried out by a number of senior investigators as well as postdoctoral fellows who have graced the Laboratory of Persistent Viral Diseases over the last 10 years. Some of the information on the nature of the endogenous glycoproteins expressed within the hematopoietic compartment of DBA/2 and C57BL mice has provided a basis for speculation, offered at the end of the report, on the possibility that anti-retroviral autoantibodies generated during the course of GVHR may be antigen-driven. endogenous retrovirus; graft-versus-host reaction; B lymphocytes; monoclonal antibodiesIn the last few years the importance of retroviral gene products as superantigens (Acha-Orbea and Palmer 1991;Choi et al. 1991) and their potential influence on the T cell repertoire (Pullen et al. 1990) has focussed attention on endogenous retroviral sequences of both mice and man. The mouse genome is replete with viral sequences related to type A (intracisternal particles), type B (mammary tumor virus) and type C (oncornavirus) retroviruses. We have studied the envelope proteins encoded by members of the latter group in normal uninoculated mice. In this report I will describe the generation of mouse monoclonal antibodies which recognize some of these proteins and the use of these reagents to identify cells which express these proteins.Before describing these experiments, however, a brief overview of terminology is in order. Murine type C retroviruses have been classified into four

show abstract

“…Avian endogenous virus loci, ev-3, ev-6, and ev-9, confer resistance to exogenous infection by subgroup E avian sarcoma/leukosis virus, via an env-mediated resistance mechanism (49). High expressions of endogenous Env proteins are associated with the mouse Rmcf gene (5,16,51) and with a gene carried by M. m. castaneus (40), both of which control FIG. 7.…”

Section: Fv-4mentioning

confidence: 99%

Virological Properties and Nucleotide Sequences of Cas-E-Type Endogenous Ecotropic Murine Leukemia Viruses in South Asian Wild Mice, Mus musculus castaneus

Ikeda

Kato

Kitani

et al. 2001

J Virol

View full text Add to dashboard Cite

Two types of endogenous ecotropic murine leukemia viruses (MuLVs), termed AKV-and Cas-E-type MuLVsr gene, infectious MuLVs were isolated in association with three of six Cas-E-type endogenous MuLV loci. The isolated viruses showed a weak syncytium-forming activity for XC cells, an interfering property of ecotropic MuLV, and a slight antigenic variation. Two genomic DNAs containing endogenous Cas-E-type MuLV were cloned and partially sequenced. All of the Cas-E-type endogenous MuLVs were closely related, hybrid-type viruses with an ecotropic env gene and a xenotropic long terminal repeat. Duplications and a deletion were found in a restricted region of the hypervariable proline-rich region of Env glycoprotein.Multiple DNA copies of the murine leukemia virus (MuLV) genome, called endogenous MuLV, are present in the chromosomal DNA of Mus musculus (M. m.) mice. MuLVs are largely classified into four groups (ecotropic, xenotropic, amphotropic, and polytropic [or dualtropic] viruses) on the bases of the host range and the interfering properties that are mainly determined by the receptor-binding specificity of the viral envelope (Env) glycoprotein. Ecotropic MuLVs infect mouse cells expressing the receptor for ecotropic MuLVs, mCAT-1 (1). There are two types of endogenous ecotropic MuLVs with a slight sequence divergence. AKV-type endogenous MuLV is carried by many laboratory strains of mice and has been well characterized. Castaneus ecotropic (Cas-E-type) MuLVs are not carried by common laboratory mice and therefore have not been characterized in detail. They are carried by geographically separated M. m. subspecies; AKV-type MuLVs were found in M. m. musculus mice populating the northern part of China, Korea, and Japan, and Cas-E-type MuLVs were found in M. m. castaneus mice populating southern Asia (from Pakistan to Japan) (23, 34). They appear to have diverged along with the subspeciation of M. musculus, probably separated by more than 10 5 to 10 6 years (23). Infectious Cas-E-type MuLVs were isolated from mice from limited areas of California in the United States (6, 9, 15; for a review, see reference 8). Interestingly, unlike AKV-type MuLVs, infectious Cas-E-type MuLVs were reported to be transmitted through sex and milk but not in the germ line in this wild mouse population (10, 11). However, it is not clear by these studies whether endogenous Cas-E-type MuLVs can produce infectious viruses and whether the previously isolated infectious Cas-E-type MuLVs are directly related to endogenous MuLVs.The Fv-4 r gene is a truncated Cas-E-type endogenous MuLV (19,22,41), which is highly homologous in the env gene to infectious Cas-Br-E MuLV (46)

show abstract

The endogenous mink cell focus-forming (MCF) gp70 linked to the Rmcf gene restricts MCF virus replication in vivo and provides partial resistance to erythroleukemia induced by Friend murine leukemia virus.

Cited by 27 publications

References 40 publications

Feline Leukemia Virus (FeLV) Disease Outcomes in a Domestic Cat Breeding Colony: Relationship to Endogenous FeLV and Other Chronic Viral Infections

Feline Leukemia Virus (FeLV) Disease Outcomes in a Domestic Cat Breeding Colony: Relationship to Endogenous FeLV and Other Chronic Viral Infections

Endogenous Retroviral Envelope Antigens Recognized by B Lymphocytes during Graft-Versus-Host Reaction.

Virological Properties and Nucleotide Sequences of Cas-E-Type Endogenous Ecotropic Murine Leukemia Viruses in South Asian Wild Mice, Mus musculus castaneus

Contact Info

Product

Resources

About