The endophyticFusariumstrains: a treasure trove of natural products

Abstract

The complexity and structural diversity of the secondary metabolites produced by endophytes make them an attractive source of natural products with novel structures that can help in treating life-changing diseases.

Cultivable Endophyte Resources in Medicinal Plants and Effects on Hosts

“…High throughput sequencing technology can explore the richn microbial resources in medicinal plants, but only a small part can be isolated, whic means that there is still a great research potential for endophytes in medicinal p Therefore, it is necessary to optimize cultivation methods to obtain more cultivable m bial resources. In the process of endophytes' isolation, the method of surface disinf At present, many alkaloids, flavonoids, phenolic acids, terpenoids, coumarins, and other substances with antioxidant activity have been isolated from endophytes and their secondary metabolites of medicinal plants [10,11,32,[95][96][97]. These natural antioxidant active substances often have anti-inflammatory, antioxidant, antibacterial, anti-tumor, antiviral and other functions [10,11,98].…”

“…The structures of the above compounds are shown in Figure 1. At present, many alkaloids, flavonoids, phenolic acids, terpenoids, coumarin other substances with antioxidant activity have been isolated from endophytes and secondary metabolites of medicinal plants [10,11,32,[95][96][97]. These natural antioxida tive substances often have anti-inflammatory, antioxidant, antibacterial, anti-tumor viral and other functions [10,11,98].…”

Protective effects of hepatic diseases by bioactive phytochemicals in Fusarium oxysporum – A review

“…Caicedo et al [ 26 ] analyzed the antioxidant capacity of Fusarium oxysporum by DPPH assay and the results revealed that the fungus had miraculous inhibitory activity that reached its scavenging activity of 51.5%. Moreover, the author [ 27 ] mentioned that F. oxysporum contained various biologically active compounds and listed 12 distinct chemical compounds. As a result, the fungus became qualified to treat different and numerous complications as it owned many biological activities.…”

Naturally occurring phenylethanoids and phenylpropanoids: antimalarial potential

“…3 Secondary metabolites (specialized metabolites) are natural compounds with a variety of biological activities and chemical congurations. [4][5][6][7][8] Among which are simple phenolics such as phenylethanoids and phenylpropanoids classed as (C6-C2) and C6-C3 compounds. Additionally, polyphenolics as lignans and neolignans constitute a signicant class of secondary metabolites.…”