The endoribonuclease Arlr is required to maintain lipid homeostasis by downregulating lipolytic genes during aging
Xiaowei Sun,
Jie Shen,
Norbert Perrimon
et al.
Abstract:While disorders in lipid metabolism have been associated with aging and age-related diseases, how lipid metabolism is regulated during aging is poorly understood. Here, we characterize the Drosophila endoribonuclease CG2145, an ortholog of mammalian EndoU that we named Age-related lipid regulator (Arlr), as a regulator of lipid homeostasis during aging. In adult adipose tissues, Arlr is necessary for maintenance of lipid storage in lipid droplets (LDs) as flies age, a phenotype that can be rescued by either hi… Show more
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