The endosymbiotic bacterium Wolbachia enhances the nonspecific resistance to insect pathogens and alters behavior of Drosophila melanogaster

Panteleev, D. Yu.; Goryacheva, I. I.; Andrianov, B. V.; Reznik, Noam; Lazebny, O. E.; Куликов, А. М.

doi:10.1134/s1022795407090153

Cited by 88 publications

(75 citation statements)

References 12 publications

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“…Although we do not infer a functional relationship underlying this association, marking it as noncausal but positive, other studies have documented Wolbachia -associated behavioral variations in invertebrates (Fleury et al 2000, Panteleev et al 2007, Peng et al 2008), and specifically in blood feeding behaviors of Aedes aegypti (L.) (Moreira et al 2009, Turley et al 2009). Wolbachia -infected, older Ae.…”

Section: Discussioncontrasting

confidence: 58%

Diversity ofWolbachia pipientisStrainwPip in a Genetically Admixtured, Above-GroundCulex pipiens(Diptera: Culicidae) Population: Association With Form Molestus Ancestry and Host Selection Patterns

et al. 2012

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Analysis of molecular genetic diversity in nine marker regions of five genes within the bacteriophage WO genomic region revealed high diversity of the Wolbachia pipentis strain wPip in a population of Culex pipiens L. sampled in metropolitan Chicago, IL. From 166 blood fed females, 50 distinct genetic profiles of wPip were identified. Rarefaction analysis suggested a maximum of 110 profiles out of a possible 512 predicted by combinations of the nine markers. A rank-abundance curve showed that few strains were common and most were rare. Multiple regression showed that markers associated with gene Gp2d, encoding a partial putative capsid protein, were significantly associated with ancestry of individuals either to form molestus or form pipiens, as determined by prior microsatellite allele frequency analysis. None of the other eight markers was associated with ancestry to either form, nor to ancestry to Cx. quinquefasciatus Say. Logistic regression of host choice (mammal vs. avian) as determined by bloodmeal analysis revealed that significantly fewer individuals that had fed on mammals had the Gp9a genetic marker (58.5%) compared with avian-fed individuals (88.1%). These data suggest that certain wPip molecular genetic types are associated with genetic admixturing in the Cx. pipiens complex of metropolitan Chicago, IL, and that the association extends to phenotypic variation related to host preference.

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Section: Discussioncontrasting

confidence: 58%

Diversity ofWolbachia pipientisStrainwPip in a Genetically Admixtured, Above-GroundCulex pipiens(Diptera: Culicidae) Population: Association With Form Molestus Ancestry and Host Selection Patterns

et al. 2012

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“…There is also a report that Wolbachia increases resistance of D. melanogaster to the pathogenic fungus Beauveria bassiana [62]. All these reports support a model of general activation of innate immunity.…”

Section: Discussionmentioning

confidence: 69%

The Bacterial Symbiont Wolbachia Induces Resistance to RNA Viral Infections in Drosophila melanogaster

2008

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Wolbachia are vertically transmitted, obligatory intracellular bacteria that infect a great number of species of arthropods and nematodes. In insects, they are mainly known for disrupting the reproductive biology of their hosts in order to increase their transmission through the female germline. In Drosophila melanogaster, however, a strong and consistent effect of Wolbachia infection has not been found. Here we report that a bacterial infection renders D. melanogaster more resistant to Drosophila C virus, reducing the load of viruses in infected flies. We identify these resistance-inducing bacteria as Wolbachia. Furthermore, we show that Wolbachia also increases resistance of Drosophila to two other RNA virus infections (Nora virus and Flock House virus) but not to a DNA virus infection (Insect Iridescent Virus 6). These results identify a new major factor regulating D. melanogaster resistance to infection by RNA viruses and contribute to the idea that the response of a host to a particular pathogen also depends on its interactions with other microorganisms. This is also, to our knowledge, the first report of a strong beneficial effect of Wolbachia infection in D. melanogaster. The induced resistance to natural viral pathogens may explain Wolbachia prevalence in natural populations and represents a novel Wolbachia–host interaction.

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“…For example, the presence of gut ßora stimulates the Toll pathway in Aedes mosquitoes, thereby enhancing resistance to Dengue virus (Xi et al 2008), although the particular bacteria that are responsible were not identiÞed. Similarly, infection with certain Wolbachia strains enhances Drosophila resistance to RNA viruses (Hedges et al 2008, Teixeira et al 2008) and pathogenic fungi (Panteleev et al 2007), but the precise mechanism is not known. We detected three separate Wolbachia-like sequences in our libraries.…”

Section: Resultsmentioning

confidence: 99%

Bacterial Communities Associated With Flea Vectors of Plague

Erickson¹,

Anderson

Cromar

et al. 2009

J Med Entomol

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The microbial flora associated with fleas may affect their ability to transmit specific pathogens, including Yersinia pestis, and also could be used to develop paratransgenesis-based approaches to interfere with transmission. To begin addressing this hypothesis, the microbial flora associated with the relatively efficient Y. pestis vectors Xenopsylla cheopis (Rothschild) (Siphonaptera: Pulicidae) and Oropsyllamontana (Baker) (Siphonaptera: Ceratophyllidae), and the inefficient vector Ctenocephalides felis felis (Bouché) (Siphonaptera: Pulicidae) were investigated using polymerase chain reaction amplification of 16S rDNA genes. DNA sequencing revealed that these species harbor distinct communities of microbial flora and suggest that Acinetobacter sp. might be used in developing anti-transmission strategies.

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The endosymbiotic bacterium Wolbachia enhances the nonspecific resistance to insect pathogens and alters behavior of Drosophila melanogaster

Cited by 88 publications

References 12 publications

Diversity ofWolbachia pipientisStrainwPip in a Genetically Admixtured, Above-GroundCulex pipiens(Diptera: Culicidae) Population: Association With Form Molestus Ancestry and Host Selection Patterns

Diversity ofWolbachia pipientisStrainwPip in a Genetically Admixtured, Above-GroundCulex pipiens(Diptera: Culicidae) Population: Association With Form Molestus Ancestry and Host Selection Patterns

The Bacterial Symbiont Wolbachia Induces Resistance to RNA Viral Infections in Drosophila melanogaster

Bacterial Communities Associated With Flea Vectors of Plague

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