2023
DOI: 10.1002/ams2.896
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The endothelial glycocalyx—All the same? No, it is not

Kodai Suzuki,
Tomotaka Miura,
Hideshi Okada

Abstract: The endothelial glycocalyx covers the lumen of blood vessels throughout the body and plays an important role in endothelial homeostasis. Advances in electron microscopy techniques have provided clues to better understand the structure and composition of identical vascular endothelial glycocalyx. The morphology and thickness of the endothelial glycocalyx differ from organ to organ. The content of the endothelial glycocalyx covering the vascular lumen differs even in the brain, heart, and lungs, which have the s… Show more

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“…The digestive tract, kidneys, and endocrine organs are fenestrated and have a glycocalyx that covers the holes [55,65,96]. The liver and bone marrow are sinusoidal, with large holes, and are not covered by a glycocalyx [97]. Thus, substances enter and exit the capillaries of the gastrointestinal tract, kidneys, liver, etc., freely, to a certain extent, through holes that are originally opened and are regulated by the function of the glycocalyx [94,98,99].…”
Section: Vascular Endothelial Glycocalyxmentioning
confidence: 99%
“…The digestive tract, kidneys, and endocrine organs are fenestrated and have a glycocalyx that covers the holes [55,65,96]. The liver and bone marrow are sinusoidal, with large holes, and are not covered by a glycocalyx [97]. Thus, substances enter and exit the capillaries of the gastrointestinal tract, kidneys, liver, etc., freely, to a certain extent, through holes that are originally opened and are regulated by the function of the glycocalyx [94,98,99].…”
Section: Vascular Endothelial Glycocalyxmentioning
confidence: 99%