The endothelial nitric oxide synthase (Glu298Asp and –786T&gt;C) gene polymorphisms are associated with coronary in-stent restenosis

Gomma, Abuzeid

doi:10.1053/euhj.2002.3400

Cited by 66 publications

(43 citation statements)

References 33 publications

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“…40 Furthermore, serum plasma activity of ACE is thought to play a major role in the development of restenosis after coronary stent implantation. 41,42 Recently, a number of articles in the literature reported on the relationship between ACE I/D polymorphisms and coronary restenosis risk [20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35] ; however, the results are inconsistent or even contradictory. This discrepancy may result from the small sample size, ethnic difference, false positive results, and/or study design in each study.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies indicate that certain genetic polymorphisms are recognized to be associated with the risk of coronary restenosis. [14][15][16][17][18][19] Among these genes, the ACE gene polymorphisms were considered as a risk factor of coronary restenosis in several published papers [20][21][22][23][24][25][26][27][28][29][30][31][32][33][34] ; however, the results of these studies were inconsistent. Rebrova et al 34 found that ACE genetic polymorphism is associated with coronary restenosis risk.…”

Section: Association Of Ace Insertion or Deletion Polymorphisms With mentioning

confidence: 99%

“…Therefore, a total of 16 journal literature articles, [20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35] with a total of 4693 subjects (1241 patients with coronary restenosis and 3452 subjects without coronary restenosis), were included in this research.…”

Section: Study Identificationmentioning

confidence: 99%

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Association of ACE insertion or deletion polymorphisms with the risk of coronary restenosis after percutaneous coronary intervention: A meta-analysis

Miao

Gong

2015

J Renin Angiotensin Aldosterone Syst

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Objective: Previous case-control studies on the relationship between the angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphisms and coronary restenosis did not reach the same conclusion. In the present study, we aimed to further evaluate the relationship between the ACE gene I/D polymorphisms and coronary restenosis, after percutaneous coronary intervention (PCI). Methods: By searching PubMed, EMBase, the Chinese Biomedical Literature Database and Wanfang database, we selected 16 case-control studies related to ACE gene I/D polymorphism and coronary restenosis after PCI. To test for heterogeneity in each study, we utilized the Q-test and I2 test. To merge the odds ratio (OR) and 95% CI, we utilized the random effects model during the analyses. Results: The present study included 4693 subjects: 1241 patients with coronary restenosis and 3452 without coronary restenosis. By meta-analysis, we found there was significant association of ACE gene I/D polymorphism with coronary restenosis (D allele versus I allele: OR = 1.92; 95% CI (1.40–2.43); p < 0.001). A subgroup analysis, by stratification according to ethnicity, also showed that this association was found not only in the Caucasian population ((D allele versus I allele: OR = 1.94; 95% CI (1.38–2.80); p < 0.001)), but also in the Asian population ((D allele versus I allele: OR = 1.83; 95% CI (1.05–3.20); p = 0.03)). After stratification according to age, we found that the D allele carriers have a higher risk for development of coronary restenosis in subjects < 60 years old (OR = 2.13; 95% CI: 1.40–3.24; p = 0.0004); while in the subjects ⩾ 60 years old, the association was present with bordering significance (OR = 1.48; 95%CI: 0.98–2.25; p = 0.06). Conclusions: The present study suggested that the ACE gene I/D polymorphism was associated with coronary restenosis, regardless of age and ethnicity.

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Section: Discussionmentioning

confidence: 99%

Section: Association Of Ace Insertion or Deletion Polymorphisms With mentioning

confidence: 99%

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Association of ACE insertion or deletion polymorphisms with the risk of coronary restenosis after percutaneous coronary intervention: A meta-analysis

Miao

Gong

2015

J Renin Angiotensin Aldosterone Syst

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“…Previous studies have identified genes associated with in-stent restenosis [14][15][16][17][18] . In this study, we report a novel finding for strong association of ALOX5AP SNPs and haplotypes with instent restenosis.…”

Section: Discussionmentioning

confidence: 99%

ALOX5AP variants are associated with in-stent restenosis after percutaneous coronary intervention

et al. 2008

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Background-Use of drug-eluting stents (DES) has reduced in-stent restenosis after percutaneous coronary intervention (PCI); however, DES are associated with late stent thrombosis. There is no accurate way to predict in-stent restenosis, although risk factors for atherosclerosis overlap those for in-stent restenosis. Therefore, we evaluated atherosclerosis candidate genes for association with in-stent restenosis.

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“…Zhang et al (47) did observe a potential involvement of 786T3 C, Glu 298 Asp, and intron 8 single-nucleotide polymorphism (SNP) variants in the atherogenic process in diabetic subjects with CAD. Other studies showed that homozygosity of Glu 298 Asp and Ϫ786T3 C polymorphisms of the NOS3 gene represented an independent risk factor for in-stent restenosis (12,40), and the 894G3 T polymorphism of NOS3 gene was associated with an increased risk of death and/or myocardial infarction within 1 yr after stent placement (13).…”

mentioning

confidence: 99%

Hyperinsulinemia and impaired leptin-adiponectin ratio associate with endothelial nitric oxide synthase polymorphisms in subjects with in-stent restenosis

Galluccio¹,

Piatti²,

Citterio³

et al. 2008

American Journal of Physiology-Endocrinology and Metabolism

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The endothelial nitric oxide synthase (Glu298Asp and –786T>C) gene polymorphisms are associated with coronary in-stent restenosis

Abstract: In patients with coronary artery disease, the possession of the 298Asp and -786C variants of the eNOS gene are a risk factor for coronary in-stent restenosis, demonstrating the importance of the nitric oxide system in restenosis.

Cited by 66 publications

References 33 publications

Association of ACE insertion or deletion polymorphisms with the risk of coronary restenosis after percutaneous coronary intervention: A meta-analysis

Association of ACE insertion or deletion polymorphisms with the risk of coronary restenosis after percutaneous coronary intervention: A meta-analysis

ALOX5AP variants are associated with in-stent restenosis after percutaneous coronary intervention

Hyperinsulinemia and impaired leptin-adiponectin ratio associate with endothelial nitric oxide synthase polymorphisms in subjects with in-stent restenosis

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