The endothelin system mediates bone modeling in the late stage of orthodontic tooth movement in rats

Sprogar, Špela; Vaupotič, Tomaž; Cör, Andrej; Drevenšek, Martina; Drevenšek, Gorazd

doi:10.1016/j.bone.2008.06.012

Cited by 41 publications

(58 citation statements)

References 38 publications

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“…32 Osteoblasts are differentiated from mesenchymal cell cursors, while mature osteoblasts form osteoids, followed by bone mineralization process. 4 In addition, VEGF can modulate the recruitment, differentiation, and activation of osteoclast precursors, thereby increasing bone resorption. VEGF also indirectly leads to bone resorption since it promotes angiogenesis in vitro, enabling new capillaries to assist in the recruitment of osteoclasts to the nearest bone surface and then to the resorption area.…”

Section: Resultsmentioning

confidence: 99%

“…3 At the tension site, new bone is formed as a result of orthodontic force during treatment. 4 Osteoblast cells are involved in bone formation which commences some 40-48 hours after the initial application of orthodontic force. Differentiation of osteoblasts subsequently begins with stem cells derived from bone marrow moving to the blood vessels.…”

mentioning

confidence: 99%

“…The migration of mesenchymal stem cells from the blood vessel wall or the activation of mesenchymal stem cell precursors and preosteoblasts formation occurs approximately 10 hours after the application of orthodontic force. 5 Mature osteoblasts form osteoid leading to a mineralization process, 4 with endothelial nitric oxide synthase (eNOS) then facilitating bone formation at the tension site. 6 Furthermore, periodontal ligaments consist of blood capillaries, very small blood vessels, at the end of the arteries.…”

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confidence: 99%

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The increased number of osteoblasts and capillaries in orthodontic tooth movement post-administration of Robusta coffee extract

Herniyati

2017

Dent. J. (Maj. Ked. Gigi)

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Section: Resultsmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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The increased number of osteoblasts and capillaries in orthodontic tooth movement post-administration of Robusta coffee extract

Herniyati

2017

Dent. J. (Maj. Ked. Gigi)

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“…Three months after surgery, OTM was performed following the method described in previous studies 23, 24 . Generally, the maxillary left molars were moved mesially by closed-coil springs (3 M Unitek, Monrovia, CA, USA) ligatured by a 0.2 mm steel ligature between the maxillary first molar and the incisors, which could generate force of a magnitude of 50 g (Appendix Fig.…”

Section: Methodsmentioning

confidence: 99%

Force-induced increased osteogenesis enables accelerated orthodontic tooth movement in ovariectomized rats

Dai

Zhou

Zhang

et al. 2017

Sci Rep

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As the number of elderly orthodontic patients increases, the impact of postmenopausal osteoporosis on orthodontic tooth movement (OTM) has attracted a great deal of attention because OTM relies on alveolar bone remodeling. The question of whether OTM causes subsequent alveolar bone loss and is harmful to alveolar bone health under osteoporotic conditions remains to be answered. The present study aimed to clarify the influences of OTM on alveolar bone in osteoporotic rats. OTM was accelerated in ovariectomized (OVX) rats as a result of increased bone resorption in the pressure area. At the same time, anabolic bone formation was promoted in the tension area during OTM in OVX rats. Micro-CT analysis of alveolar bone revealed a decrease in BMD, BV/TV and Tb.Th. in the OTM group compared with that in non-OTM rats on day 21 of OTM, suggesting that OTM caused alveolar bone loss in OVX rats during OTM. However, the OTM-induced bone loss could be recovered 3 months after OTM in OVX rats. Thus, our findings suggest that increased osteogenesis may compensate for the increased bone resorption during and after OTM and enable effective accelerated OTM in OVX rats.

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“…It has been suggested that ET-1 is involved in orthodontic tooth movement probably by enhancing bone resorption [28]. In addition to an indirect participation in periodontitis via the induction of inflammatory cytokines, ET-1 may directly aggravate the disease through the enhancement of osteoclast formation, eventually leading to alveolar bone loss.…”

Section: Discussionmentioning

confidence: 99%

Endothelin Regulates Porphyromonas gingivalis-Induced Production of Inflammatory Cytokines

Son

Bak

Kim³

et al. 2016

PLoS ONE

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Periodontitis is a very common oral inflammatory disease that results in the destruction of supporting connective and osseous tissues of the teeth. Although the exact etiology is still unclear, Gram-negative bacteria, especially Porphyromonas gingivalis in subgingival pockets are thought to be one of the major etiologic agents of periodontitis. Endothelin (ET) is a family of three 21-amino acid peptides, ET-1, -2, and -3, that activate G protein-coupled receptors, ETA and ETB. Endothelin is involved in the occurrence and progression of various inflammatory diseases. Previous reports have shown that ET-1 and its receptors, ETA and ETB are expressed in the periodontal tissues and, that ET-1 levels in gingival crevicular fluid are increased in periodontitis patients. Moreover, P. gingivalis infection has been shown to induce the production of ET-1 along with other inflammatory cytokines. Despite these studies, however, the functional significance of endothelin in periodontitis is still largely unknown. In this study, we explored the cellular and molecular mechanisms of ET-1 action in periodontitis using human gingival epithelial cells (HGECs). ET-1 and ETA, but not ETB, were abundantly expressed in HGECs. Stimulation of HGECs with P. gingivalis or P. gingivalis lipopolysaccharide increased the expression of ET-1 and ETA suggesting the activation of the endothelin signaling pathway. Production of inflammatory cytokines, IL-1β, TNFα, and IL-6, was significantly enhanced by exogenous ET-1 treatment, and this effect depended on the mitogen-activated protein kinases via intracellular Ca2+ increase, which resulted from the activation of the phospholipase C/inositol 1,4,5-trisphosphate pathway. The inhibition of the endothelin receptor-mediated signaling pathway with the dual receptor inhibitor, bosentan, partially ameliorated alveolar bone loss and immune cell infiltration. These results suggest that endothelin plays an important role in P. gingivalis-mediated periodontitis. Thus, endothelin antagonism may be a potential therapeutic approach for periodontitis treatment.

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The endothelin system mediates bone modeling in the late stage of orthodontic tooth movement in rats

Cited by 41 publications

References 38 publications

The increased number of osteoblasts and capillaries in orthodontic tooth movement post-administration of Robusta coffee extract

The increased number of osteoblasts and capillaries in orthodontic tooth movement post-administration of Robusta coffee extract

Force-induced increased osteogenesis enables accelerated orthodontic tooth movement in ovariectomized rats

Endothelin Regulates Porphyromonas gingivalis-Induced Production of Inflammatory Cytokines

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