The Enduring Menace of MRSA: Incidence, Treatment, and Prevention in a County Jail

Deger, Grant E.; Quick, David W.

doi:10.1177/1078345808326623

Cited by 10 publications

(7 citation statements)

References 8 publications

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“…The limited number of reports published, however, focused primarily on MRSA, followed by Mycobacteria tuberculosis and Chlamydia (4,12,13,(40)(41)(42)62). In this report, the antimicrobial susceptibility of 123 CCF Acinetobacter isolates against 18 antibiotics was determined, followed by a series of experiments to elucidate the mechanisms of resistance in FQs, aminoglycosides, and tigecycline in these CCF isolates.…”

Section: Discussionmentioning

confidence: 99%

Phenotypic and Molecular Characterization of Acinetobacter Clinical Isolates Obtained from Inmates of California Correctional Facilities

et al. 2011

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Acinetobacter spp. increasingly have been wreaking havoc in hospitals and communities worldwide. Although much has been reported regarding Acinetobacter isolates responsible for nosocomial infections, little is known about these organisms in correctional facilities. In this study, we performed species identification, examined the antibiotic resistance profiles, and determined the mechanisms of resistance and clonal relationships of 123 Acinetobacter isolates obtained from inmates of 20 California correctional facilities (CCFs). We found that 57.7% of the isolates belong to A. baumannii, followed by isolates of Acinetobacter genomic species 3 (gen. sp. 3; 23.6%) and of Acinetobacter gen. sp. 13TU (10.6%). Multidrug-resistant (MDR) CCF isolates were found in only six CCFs. Additionally, DNA sequences of gyrA and parC genes were consistent with fluoroquinolone (FQ) susceptibility phenotypes. Furthermore, the presence of class 1 integrons was detected in 15 CCF isolates, all of which are MDR. Integron-associated gene cassettes encode several aminoglycoside modification enzymes, which correlate with most of the aminoglycoside-resistant phenotypes. Antimicrobial susceptibility testing in the presence of Phe-Arg-␤-naphthylamide dihydrochloride and 1-(1-naphthylmethyl)-piperazine indicated the involvement of efflux pumps in the FQ resistance of only a few CCF isolates. Finally, genetic profiling showed that there was no evidence of A. baumannii outbreaks in CCFs. Instead, our analyses revealed only limited clonal dissemination of mostly non-MDR A. baumannii strains in a few facilities. This study represents the first report to characterize phenotypic and molecular features of Acinetobacter isolates in correctional facilities, which provides a baseline for monitoring the antimicrobial resistance changes and dissemination patterns of these organisms in such specialized institutions.

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Section: Discussionmentioning

confidence: 99%

Phenotypic and Molecular Characterization of Acinetobacter Clinical Isolates Obtained from Inmates of California Correctional Facilities

et al. 2011

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“…In some prison settings, MRSA may be implicated more that half of skin and soft tissue infections [6,7]. However, there are no data on MRSA in Brazilian correctional institutions.…”

Section: Introductionmentioning

confidence: 99%

Nasopharyngeal carriage of Staphylococcus aureus among imprisoned males from Brazil without exposure to healthcare: risk factors and molecular characterization

Witzel

Fortaleza

Souza

et al. 2014

Ann Clin Microbiol Antimicrob

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BackgroundPrevious studies report high prevalence of Methicillin-resistant Staphylococcus aureus (MRSA) colonization among imprisoned populations. However, there are no data on that prevalence in Brazilian correctional institutions.FindingsWe tested 302 male prisoners for nasopharyngeal colonization with Staphylococcus aureus from February 2009 through April 2010. The overall isolation rate of S. aureus was 16.5% (50/302). Men who had sex with men, users of inhalatory drugs and those with previous lung or skin diseases were more likely to be colonized with S. aureus. MRSA was isolated from 0.7% of subjects (2/302). The two Community-associated (CA)-MRSA belonged to ST5 but were unrelated based on the PFGE results. Both harbored SCCmec IV, and did not possess the Panton-Valentine Leukocidin gene.ConclusionWe found low prevalence of S. aureus and CA-MRSA among prisoners. MRSA isolates ST5 from two subjects harboured SCCmec IV and presented different PFGE patterns.

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“…7 The second, by Bick, is more general, noting that "Most jails and prisons were con structed to maximize public safety, not to mini mize the transmission of disease or to efficiently deliver medical care." First, "the danger of introducing lice or conta gious infections, for example, is well document ed."…”

Section: He Alth S Afe T Y and S Trip Se Ar Che Smentioning

confidence: 99%

Strip Searches in the Supreme Court — Prisons and Public Health

Annas

2012

N Engl J Med

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The Enduring Menace of MRSA: Incidence, Treatment, and Prevention in a County Jail

Cited by 10 publications

References 8 publications

Phenotypic and Molecular Characterization of Acinetobacter Clinical Isolates Obtained from Inmates of California Correctional Facilities

Phenotypic and Molecular Characterization of Acinetobacter Clinical Isolates Obtained from Inmates of California Correctional Facilities

Nasopharyngeal carriage of Staphylococcus aureus among imprisoned males from Brazil without exposure to healthcare: risk factors and molecular characterization

Strip Searches in the Supreme Court — Prisons and Public Health

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