The ENEIDA registry (Nationwide study on genetic and environmental determinants of inflammatory bowel disease) by GETECCU: Design, monitoring and functions

Zabana, Yamile; Panés, Julián; Nos, Pilar; Gomollón, Fernando; Esteve, María; García–Sánchez, Valle; Gisbert, Javier P.; Barreiro-de-Acosta, Manuel; Domènech, Eugeni

doi:10.1016/j.gastre.2020.05.006

Cited by 17 publications

(17 citation statements)

References 28 publications

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“…This was an observational, prospective, multicenter, nationwide study carried out with data from ENEIDA project (16). ENEIDA is a large, prospectively maintained nationwide registry of IBD patients in Spain.…”

Section: Methodsmentioning

confidence: 99%

Immigrant IBD Patients in Spain Are Younger, Have More Extraintestinal Manifestations and Use More Biologics Than Native Patients

et al. 2022

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BackgroundPrevious studies comparing immigrant ethnic groups and native patients with IBD have yielded clinical and phenotypic differences. To date, no study has focused on the immigrant IBD population in Spain.MethodsProspective, observational, multicenter study comparing cohorts of IBD patients from ENEIDA-registry who were born outside Spain with a cohort of native patients.ResultsWe included 13,524 patients (1,864 immigrant and 11,660 native). The immigrants were younger (45 ± 12 vs. 54 ± 16 years, p < 0.001), had been diagnosed younger (31 ± 12 vs. 36 ± 15 years, p < 0.001), and had a shorter disease duration (14 ± 7 vs. 18 ± 8 years, p < 0.001) than native patients. Family history of IBD (9 vs. 14%, p < 0.001) and smoking (30 vs. 40%, p < 0.001) were more frequent among native patients. The most prevalent ethnic groups among immigrants were Caucasian (41.5%), followed by Latin American (30.8%), Arab (18.3%), and Asian (6.7%). Extraintestinal manifestations, mainly musculoskeletal affections, were more frequent in immigrants (19 vs. 11%, p < 0.001). Use of biologics, mainly anti-TNF, was greater in immigrants (36 vs. 29%, p < 0.001). The risk of having extraintestinal manifestations [OR: 2.23 (1.92–2.58, p < 0.001)] and using biologics [OR: 1.13 (1.0–1.26, p = 0.042)] was independently associated with immigrant status in the multivariate analyses.ConclusionsCompared with native-born patients, first-generation-immigrant IBD patients in Spain were younger at disease onset and showed an increased risk of having extraintestinal manifestations and using biologics. Our study suggests a featured phenotype of immigrant IBD patients in Spain, and constitutes a new landmark in the epidemiological characterization of immigrant IBD populations in Southern Europe.

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Section: Methodsmentioning

confidence: 99%

Immigrant IBD Patients in Spain Are Younger, Have More Extraintestinal Manifestations and Use More Biologics Than Native Patients

et al. 2022

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“…This was an observational, multicentre, nationwide, case‐control study comprising patients with CD and UGI. Patients were selected from the ENEIDA registry of the Spanish Working Group in Crohn's and Colitis (GETECCU), which is a prospectively maintained database set up in 2006, containing demographic, clinical and therapeutic data on patients with inflammatory bowel disease (IBD) 11 . It was conducted with the participation of 49 centres of the 71 belonging to the ENEIDA project at the time of the study initiation, and it was coordinated by investigators from Hospital Universitari Mútua Terrassa.…”

Section: Methodsmentioning

confidence: 99%

Clinical features, therapeutic requirements and evolution of patients with Crohn’s disease and upper gastrointestinal involvement (CROHNEX study)

Sainz¹,

Zabana²,

Miguel³

et al. 2021

Aliment Pharmacol Ther

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Summary Background Crohn's disease (CD) with upper gastrointestinal involvement (UGI) may have a more aggressive and refractory course. However, evidence on this phenotype of patients is scarce. Aims To identify the clinical characteristics, therapeutic requirements and complications associated with UGI in CD Methods Nationwide study of cases (UGI, UGI plus ileal/ileocolonic involvement) paired with controls (ileal/ileocolonic involvement) from the ENEIDA registry. Cases were matched to 2 controls by year of diagnosis ± 2.5 years. Patients with exclusive/predominant colonic location or complex perianal fistula were excluded. Results Of 24 738 patients with CD in the ENEIDA registry, we identified 4058 with UGI (16% of the total CD cohort). Finally, 854 cases and 1708 controls were included. Cases were independently associated to extensive involvement (OR 2.7 [2.2‐3.3], P < 0.0001), strictures [OR 1.8 (1.5‐2.2), P < 0.0001], chronic iron deficiency anaemia [OR 2.2 (1.3‐3.2), P < 0.001] and use of second‐line biologics [OR 1.7 (1.1‐2.6), P = 0.021]. The median stricture‐free time was 14 years (95% CI, 12‐16) for cases vs 21 years (95% CI, 19‐23) for controls (P < 0.0001). Cases with isolated UGI compared to UGI plus ileal/ileocolonic more frequently had localised disease [OR 0.5(0.3‐0.8), P = 0.003] and underwent more endoscopic stricture dilations [OR 2.7(1.3‐5.4), P = 0.006]. Conclusions The largest cohort of patients with CD and UGI provides information on the natural history of this particular phenotype. Increased awareness of the clinical picture and therapeutic requirements of these patients could lead to earlier diagnosis and treatment of upper gastrointestinal lesions, preventing the structural damage frequently seen in these patients at diagnosis and during follow‐up.

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“…Patients were recruited from the IBD Unit and all of them had previously been registered in ENEIDA (Nationwide study on genetic and environmental determinants of inflammatory bowel disease) database. 5 During August of 2020, patients were contacted by telephone by two trained researchers not involved in the patient's medical care. Inclusion criteria were age ≥18 years old and clinic, endoscopic/imaging and histological diagnosis of Crohn's Disease (CD), Ulcerative Colitis (UC) or Indeterminate Colitis (IC) for at least 6 months.…”

Section: Methodsmentioning

confidence: 99%

Impact of the lockdown period due to the COVID-19 pandemic in patients with inflammatory bowel disease

Refaie

Mateo

Domínguez

et al. 2022

Gastroenterología y Hepatología (English Edition)

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The ENEIDA registry (Nationwide study on genetic and environmental determinants of inflammatory bowel disease) by GETECCU: Design, monitoring and functions

Cited by 17 publications

References 28 publications

Immigrant IBD Patients in Spain Are Younger, Have More Extraintestinal Manifestations and Use More Biologics Than Native Patients

Immigrant IBD Patients in Spain Are Younger, Have More Extraintestinal Manifestations and Use More Biologics Than Native Patients

Clinical features, therapeutic requirements and evolution of patients with Crohn’s disease and upper gastrointestinal involvement (CROHNEX study)

Impact of the lockdown period due to the COVID-19 pandemic in patients with inflammatory bowel disease

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