Sunflower is an important industrial crop since it is grown all over the world for oil production, while Johnsongrass (Sorghum halepense (L.) Pers.) is characterized by great competitiveness and can severely impair plant growth and crop productivity. Thus, a two-year field experiment was conducted to evaluate the impact of Johnsongrass control practices on plant growth, seed yield, and oil content of sunflower crop. The results indicated that Johnsongrass competition negatively affected sunflower growth and productivity as the lowest values of height, dry biomass, seed, and oil yields were recorded at the weed-infested treatment, followed by the weed infested for 30 days after sowing. All the other treatments had a positive effect on vegetative and yield parameters. Moreover, fluazifop-p-butyl, quizalofop-p-ethyl, and the combination of fluazifop-p-butyl and imazamox effectively controlled johnsongrass. Specifically, in 2020, the lowest dry weight of Johnsongrass was observed in the plots where fluazifop-p-butyl + imazamox were applied. Thus, the results of this study clearly showed that the use of the above-mentioned herbicides can improve the seed and oil yield of a sunflower crop by managing johnsongrass, while the competition of this rapidly growing weed for a short period of 30 days can significantly reduce crop yield.