The enhanced immune response of hepatitis B virus DNA vaccine using SiO2@LDH nanoparticles as an adjuvant

Anti‐Metastatic and Anti‐Angiogenic Activities of Core–Shell SiO2@LDH Loaded with Etoposide in Non‐Small Cell Lung Cancer

“…SiO 2 @LDH has a 20 nm extend with lamellar crystallized LDH on the surface, whereas SiO 2 @LDH‐VP16 showed a denser dimensional core–shell architecture compare to SiO 2 nanoparticles alone 24. Result of dynamic light scattering (DLS) of SiO 2 @LDH‐VP16 showed an average diameter of about 217 nm, which supported the observation of TEM photo (Figure S3, Supporting Information).…”

“…Our recent findings propose that well‐dispersed 3D SiO 2 @LDH hierarchical spheres serve as an immune adjuvant 24. Such core–shell LDH materials were constructed using layer‐by‐layer deposition and were shown to be an excellent non‐viral gene delivery system, according to our exploration.…”

“…The co‐location photos indicate that SiO 2 @LDH‐VP16 is acting on the cytomembrane and microtubules to suppress the cancer metastasis. Besides, our previous publications have already done some exploration on the mechanism of uptake of VP16 and SiO 2 @LDH, results illuminated that the way LDH‐VP16 and SiO 2 @LDH get into cells depends on the caveolae‐mediated pathway 16, 24. The standard of categorizing pathways depends on the production of distinct derivatives.…”

“…The standard of categorizing pathways depends on the production of distinct derivatives. Moreover, the cellular uptake progress ought to be energy‐dependent 24, 45. The clear perception of cellular uptake matters to further study on the mechanism.…”

Hierarchical layered double hydroxide nanocomposites: structure, synthesis and applications

“…14 This type of morphology has been seen in most cases of coprecipitation and direct deposition, 42,55 and sometimes in the sol-gel method. 46 The linkage between the LDH shell and the metal oxide core has been proposed as MI-O-MII bonds where MI and MII represent metal cations from LDH and the core, respectively. 40,56 There are two possible interactions between the core and the shell via MI-O-MII bonds: (1) MI-O-MII bonds perpendicular to the LDH layer generate the horizontally oriented LDH shell, and (2) MI-O-MII bonds parallel to the LDH layer form the vertically oriented LDH shell.…”