The emergence of drug-resistant bacteria poses a serious threat to human health and safety, thus requiring the exploration of effective antibacterial strategies. Herein, BiOCl nanosheets were synthesized using a polyol solvothermal method, and then Bi 2 S 3 nanorods were in situ grown on the surface of BiOCl by doping S element with thioacetamide, forming BiOCl@ Bi 2 S 3 composites. The experimental results show that in comparison to BiOCl nanosheets, the BiOCl@Bi 2 S 3 composite enhances the photodynamic, sonodynamic, and thermal effects under the combined action of ultrasound (US) and 808 nm nearinfrared (NIR) light to generate more radical oxygen species (ROS) and induces local hyperthermia. Therefore, under the conditions of photoacoustic combination for 20 min, the composite material has excellent rapid antibacterial effect of 99.7% against Staphylococcus aureus and 100.0% against Escherichia coli. Additionally, the BiOCl@Bi 2 S 3 composite has a good biocompatibility with NIH-3T3 cells. This study will provide insights into the design of efficient and safe antibacterial materials.