The Enigma of Carcinoids

Chung, Daniel C.

doi:10.1053/j.gastro.2015.05.029

Cited by 3 publications

(5 citation statements)

References 10 publications

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“…[1][2][3][4][5] Clinical diagnosis of SI-NET is difficult owing to their slow tumor growth and mild symptoms, and many patients with SI-NET are often diagnosed late with advanced disease and a poor prognosis. [1][2][3][4][5] Earlier studies proposed that these tumors were derived from intraepithelial enteroendocrine cells (EECs). 1,2 The primary candidate for the cellular origin of SI-NETs is the serotonin-producing enterochromaffin cells (EC); however, the exact histogenesis of SI-NETS has not been defined.…”

mentioning

confidence: 99%

Are Facultative Reserve ISCs the Cellular Origin of Familial Small Intestinal Neuroendocrine Tumors?

Dempsey¹

2016

Gastroenterology

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confidence: 99%

Are Facultative Reserve ISCs the Cellular Origin of Familial Small Intestinal Neuroendocrine Tumors?

Dempsey¹

2016

Gastroenterology

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“…Nets consist of a heterogeneous tumor group which originate from neuroendocrine cells and secrete various bioamines and peptides[ 12 ]. The incidence of NETs has increased from 1.9 to 5.2 per 100000 people per year over the last three decades.…”

Section: Discussionmentioning

confidence: 99%

“…Small intestine neuroendocrine tumors arise from intestinal enterochromaffin cells and can be recognized by typical tumor cell serotonin immunoreactivity. They account for 1/4 of all small intestine neoplasms and present at a mean age of 65 years with a slight male predominance[ 1 , 2 , 9 , 12 ]. Due to the absence of specific clinical manifestations except for the carcinoid syndrome, along with the absence of specific blood biomarkers, there is usually a notable delay in the establishment of the correct diagnosis[ 9 , 12 ].…”

Section: Discussionmentioning

confidence: 99%

“…They account for 1/4 of all small intestine neoplasms and present at a mean age of 65 years with a slight male predominance[ 1 , 2 , 9 , 12 ]. Due to the absence of specific clinical manifestations except for the carcinoid syndrome, along with the absence of specific blood biomarkers, there is usually a notable delay in the establishment of the correct diagnosis[ 9 , 12 ]. Similarly, in our case, the patient suffered from atypical episodes of abdominal pain and loss of weight a year before she irreversibly deteriorated and presented to the emergency department.…”

Section: Discussionmentioning

confidence: 99%

“…Mesenteric metastases occur in high frequency and mainly concern the regional mesenteric and paraaortic lymph nodes. In a recent large series of patients with small intestine NET, mesenteric metastases presented on 93% of operated patients at operation, whereas 61% also had liver metastases[ 9 , 12 ]. When the liver is involved, carcinoid syndrome may develop.…”

Section: Discussionmentioning

confidence: 99%

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Midgut neuroendocrine tumor presenting with acute intestinal ischemia

Mantzoros¹,

Savvala²,

Ioannidis³

et al. 2017

WJG

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Neuroendocrine tumors represent a heterogeneous group of neoplasms that arise from neuroendocrine cells and secrete various peptides and bioamines. While gastrointestinal neuroendocrine tumors, commonly called carcinoids, account for about 2/3 of all neuroendocrine tumors, they are relatively rare. Small intestine neuroendocrine tumors originate from intestinal enterochromaffin cells and represent about 1/4 of small intestine neoplasms. They can be asymptomatic or cause nonspecific symptoms, which usually leads to a delayed diagnosis. Imaging modalities can aid diagnosis and surgery remains the mainstay of treatment. We present a case of a jejunal neuroendocrine tumor that caused nonspecific symptoms for about 1 year before manifesting with acute mesenteric ischemia. Abdominal X-rays revealed pneumatosis intestinalis and an abdominal ultrasound and computed tomography confirmed the diagnosis. The patient was submitted to segmental enterectomy. Histopathological study demonstrated a neuroendocrine tumor with perineural and arterial infiltration and lymph node metastasis. The postoperative course was uneventful and the patient denied any adjuvant treatment.

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Small bowel neuroendocrine tumor presenting with chronic diarrhea and mesenteric ischemia: A case report

Sawaf,

Abbarh,

Ahmed

et al. 2024

Clinical Case Reports

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Key Clinical MessageThe diagnosis of gastrointestinal neuroendocrine tumors is often challenging owing to the nonspecific presentation. This may lead to delayed diagnosis and serious, rare complications, such as acute mesenteric ischemia. This case highlights the importance of early recognition and the need for a multidisciplinary approach to managing such cases.AbstractGastrointestinal (GI) neuroendocrine tumors (NETs) are rare neoplasms originating from neuroendocrine cells within the digestive tract. Despite their rarity, their incidence is increasing, necessitating a better understanding of their presentation and management. In the present report, we present a case of duodenal bulb NET that caused chronic diarrhea and unintentional weight loss for 2 years before manifesting as acute mesenteric ischemia. This case sheds light on the diagnostic challenges associated with GI NETs, particularly in cases with nonspecific symptoms. In addition, it underscores the importance of prompt recognition and management, as evidenced by the progression of the patient to acute mesenteric ischemia.

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The Enigma of Carcinoids

Cited by 3 publications

References 10 publications

Are Facultative Reserve ISCs the Cellular Origin of Familial Small Intestinal Neuroendocrine Tumors?

Are Facultative Reserve ISCs the Cellular Origin of Familial Small Intestinal Neuroendocrine Tumors?

Midgut neuroendocrine tumor presenting with acute intestinal ischemia

Small bowel neuroendocrine tumor presenting with chronic diarrhea and mesenteric ischemia: A case report

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