The Enigma of Intrahepatic Cholestasis of Pregnancy: Lessons from Chile

Reyes, Humberto

doi:10.1002/hep.1840020114

Cited by 128 publications

(17 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…While human myometrial cells have an increased oxytocin-receptors expression after being incubated with cholic acid [69]. Finally, the duration of exposure to high BA levels is likely to influence the myometrial function as suggested by some studies showing a positive correlation between the earlier onset of ICP and the degree of prematurity [47,53].…”

Section: Foetal Morbidity and Mortalitymentioning

confidence: 94%

“…Interestingly, perinatal mortality seems to have fallen from 9-11% in older studies to 2-3.5% in more recent series [3,4,[45][46][47], although foetal deaths still continue to occur despite active therapies and management [3,[48][49][50][51]. Following the recognition of its risks for the foetus ICP has been more accurately diagnosed and its incidence has doubled in a 20-year period.…”

Section: Foetal Morbidity and Mortalitymentioning

confidence: 97%

“…ICP has been associated with prematurity and other adverse events including perinatal morbidity, meconium passage and abnormal intrapartum foetal heart pattern [3,[45][46][47]. Interestingly, perinatal mortality seems to have fallen from 9-11% in older studies to 2-3.5% in more recent series [3,4,[45][46][47], although foetal deaths still continue to occur despite active therapies and management [3,[48][49][50][51].…”

Section: Foetal Morbidity and Mortalitymentioning

confidence: 99%

See 2 more Smart Citations

Intrahepatic Cholestasis of Pregnancy and Bile Acids Induced Lung Injury in Newborn Infants

Zecca¹,

Luca²,

Marras³

et al. 2007

CPR

View full text Add to dashboard Cite

Intrahepatic cholestasis of pregnancy (ICP) is a clinical syndrome of unknown pathophysiology, occurring during the second half of pregnancy and persisting until delivery. The incidence of ICP varies from 0.1% to 1.5% of pregnancies in Europe, North America and Australia and from 9.2% to 15.6% in South American countries such as Bolivia and Chile. This syndrome has been associated with increased foetal distress, intrauterine death, premature delivery, perinatal mortality and, more recently, with the occurrence of respiratory distress syndrome in the newborn infant. Bile acids (BA) are supposed to be the main mediators for these complications because ICP seriously impairs the placental clearance of foetal BA leading to a dangerous accumulation of these compounds within the foetus and the newborn. Cholestatic pregnancies have to be considered high risk ones, recent reports showing that BA can interfere with surfactant metabolism and are particularly harmful for the developing lung.This review summarizes existing literature data on this topic with particular emphasis on bile acids-induced lung injury. The authors discuss possible mechanisms of lung damage and highlight future research perspectives in this field.

show abstract

Section: Foetal Morbidity and Mortalitymentioning

confidence: 94%

Section: Foetal Morbidity and Mortalitymentioning

confidence: 97%

Section: Foetal Morbidity and Mortalitymentioning

confidence: 99%

See 1 more Smart Citation

Intrahepatic Cholestasis of Pregnancy and Bile Acids Induced Lung Injury in Newborn Infants

Zecca¹,

Luca²,

Marras³

et al. 2007

CPR

View full text Add to dashboard Cite

show abstract

“…Intrahepatic cholestasis of pregnancy (ICP; OMIM 147480) is a liver disease unique to pregnancy, which usually manifests during the second or third trimester and disappears spontaneously after delivery 1 2. The main sign is pruritus, which may cause considerable discomfort, and the potential risks for the pregnancy are premature delivery and sudden intrauterine death.…”

mentioning

confidence: 99%

ABCB4 gene mutations and single-nucleotide polymorphisms in women with intrahepatic cholestasis of pregnancy

Bacq

Gendrot

Perrotin

et al. 2009

Journal of Medical Genetics

View full text Add to dashboard Cite

show abstract

“…Fulminant hepatitis was seen in high percentage in third trimester pregnant women with high maternal mortality ranging from 15-45% [6,7] . Pruritus with elevated serum bile acids which is often seen in second half of pregnancy resolving after delivery is considered as intrahepatic cholestasis [8] . Recurrence in subsequent pregnancies is widely seen.…”

Section: A Study Of Liver Disorder and Its Consequences In Pregnant Wmentioning

confidence: 99%

A study of liver disorder and its consequences in pregnant women with jaundice in tertiary care centre in Belgaum, Karnataka, India

Karegoudar¹,

Dhirubhai²,

Dhital³

et al. 2014

IOSRJDMS

View full text Add to dashboard Cite

show abstract

The Enigma of Intrahepatic Cholestasis of Pregnancy: Lessons from Chile

Cited by 128 publications

References 56 publications

Intrahepatic Cholestasis of Pregnancy and Bile Acids Induced Lung Injury in Newborn Infants

Intrahepatic Cholestasis of Pregnancy and Bile Acids Induced Lung Injury in Newborn Infants

ABCB4 gene mutations and single-nucleotide polymorphisms in women with intrahepatic cholestasis of pregnancy

A study of liver disorder and its consequences in pregnant women with jaundice in tertiary care centre in Belgaum, Karnataka, India

Contact Info

Product

Resources

About