2024
DOI: 10.3390/cells13090788
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The Enigma of Norbormide, a Rattus-Selective Toxicant

Fabio Fusi,
Simona Saponara,
Margaret A. Brimble
et al.

Abstract: Norbormide (NRB) is a Rattus-selective toxicant, which was serendipitously discovered in 1964 and formerly marketed as an eco-friendly rodenticide that was deemed harmless to non-Rattus species. However, due to inconsistent efficacy and the emergence of second-generation anticoagulants, its usage declined, with registration lapsing in 2003. NRBs’ lethal action in rats entails irreversible vasoconstriction of peripheral arteries, likely inducing cardiac damage: however, the precise chain of events leading to fa… Show more

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